Characterization of intramolecular interactions of HIV-1 accessory protein Nef by differential scanning calorimetry

The interactions between the N-terminal arm and the structural core of Nef, an HIV-1 accessory protein, have been studied by high sensitivity differential scanning calorimetry. Critical interactions have been identified by measuring the structural energetics of both truncation and point mutants of t...

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Veröffentlicht in:	Biophysical chemistry 2007-03, Vol.126 (1), p.36-42
Hauptverfasser:	Groesch, Teresa D., Freire, Ernesto
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Amino Acid Sequence Calorimetry, Differential Scanning Differential scanning calorimetry Gene Products, nef - chemistry Gene Products, nef - genetics HIV Intraprotein interaction Nef nef Gene Products, Human Immunodeficiency Virus Peptide Hydrolases - chemistry Point Mutation Protein Structure, Secondary
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