Topoisomerase II binds importin α isoforms and exportin/CRM1 but does not shuttle between the nucleus and cytoplasm in proliferating cells

Resistance to anticancer drugs that target DNA topoisomerase II (topo II) isoforms α and/or β is associated with decreased nuclear and increased cytoplasmic topo IIα. Earlier studies have confirmed that functional nuclear localization and export signal sequences (NLS and NES) are present in both iso...

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Veröffentlicht in:	Experimental cell research 2007-02, Vol.313 (3), p.627-637
Hauptverfasser:	Mirski, Shelagh E.L., Sparks, Kathryn E., Friedrich, Beate, Köhler, Matthias, Mo, Yin-Yuan, Beck, William T., Cole, Susan P.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha Karyopherins - metabolism Animals Cell Line Cell Nucleus - metabolism Cell Proliferation Chlorocebus aethiops COS Cells CRM1 Cytoplasm - metabolism DNA topoisomerase II DNA Topoisomerases, Type II - metabolism Exportin 1 Protein HeLa Cells Humans Importin α Karyopherins - metabolism Nuclear export Nuclear import Nuclear localization Nucleocytoplasmic shuttling Protein Isoforms Protein Transport Receptors, Cytoplasmic and Nuclear - metabolism Transfection
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