Involvement of G-protein βγ subunits on the influence of inhibitory α2-autoreceptors on the angiotensin AT1-receptor modulation of noradrenaline release in the rat vas deferens

The influence of alpha2-autoreceptors on the facilitation of [3H]-noradrenaline release mediated by angiotensin II was studied in prostatic portions of rat vas deferens preincubated with [3H]-noradrenaline. Angiotensin II enhanced tritium overflow evoked by trains of 100 pulses at 8 Hz, an effect th...

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Veröffentlicht in:	Neurochemistry international 2006-12, Vol.49 (7), p.698-707
Hauptverfasser:	TALAIA, Carlos, QUEIROZ, Gloria, PINHEIRO, Helder, MOURA, Daniel, GONCALVES, Jorge
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Antagonists - pharmacology Angiotensin II - metabolism Angiotensin II - pharmacology Animals Autoreceptors - drug effects Autoreceptors - metabolism Biological and medical sciences Electric Stimulation Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology GTP-Binding Protein beta Subunits - antagonists & inhibitors GTP-Binding Protein beta Subunits - metabolism GTP-Binding Protein gamma Subunits - antagonists & inhibitors GTP-Binding Protein gamma Subunits - metabolism Male Neural Inhibition - drug effects Neural Inhibition - physiology Norepinephrine - metabolism Norepinephrine - secretion Pertussis Toxin - pharmacology Presynaptic Terminals - drug effects Presynaptic Terminals - metabolism Presynaptic Terminals - secretion Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Rats Rats, Wistar Receptor Cross-Talk - drug effects Receptor Cross-Talk - physiology Receptor, Angiotensin, Type 1 - drug effects Receptor, Angiotensin, Type 1 - metabolism Receptors, Adrenergic, alpha-2 - drug effects Receptors, Adrenergic, alpha-2 - metabolism Signal Transduction - drug effects Signal Transduction - physiology Sympathetic Fibers, Postganglionic - drug effects Sympathetic Fibers, Postganglionic - metabolism Sympathetic Fibers, Postganglionic - secretion Synaptic Transmission - drug effects Synaptic Transmission - physiology Tritium Type C Phospholipases - antagonists & inhibitors Type C Phospholipases - metabolism Vas Deferens - drug effects Vas Deferens - innervation Vas Deferens - metabolism Vertebrates: nervous system and sense organs
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