A prospective study of PET/CT in initial staging of small-cell lung cancer: comparison with CT, bone scintigraphy and bone marrow analysis
Background: Small-cell lung cancer (SCLC) accounts for 15%–20% of all lung cancer cases. Accurate and fast staging is mandatory when choosing treatment, but current staging procedures are time consuming and lack sensitivity. Patients and methods: A prospective study was designed to examine the role...
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| Veröffentlicht in: | Annals of oncology 2007-02, Vol.18 (2), p.338-345 |
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| container_title | Annals of oncology |
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| creator | Fischer, B.M. Mortensen, J. Langer, S.W. Loft, A. Berthelsen, A.K. Petersen, B.L. Daugaard, G. Lassen, U. Hansen, H.H. |
| description | Background: Small-cell lung cancer (SCLC) accounts for 15%–20% of all lung cancer cases. Accurate and fast staging is mandatory when choosing treatment, but current staging procedures are time consuming and lack sensitivity.
Patients and methods: A prospective study was designed to examine the role of combined positron emission tomography/computed tomography (PET/CT) compared with standard staging (CT, bone scintigraphy and immunocytochemical assessment of bone marrow biopsy) of patients with SCLC. Thirty-four consecutive patients were included. Twenty-nine patients received initial PET/CT.
Results: PET/CT caused change of stage in 5/29 (17%). Excluding patients with unconfirmed findings or pleural effusion, the sensitivity for accurate staging of patients with extensive disease was the following: for standard staging 79%, PET 93% and PET/CT 93%. Specificity was 100%, 83% and 100%, respectively.
Conclusion: The results from this first study on PET/CT in SCLC indicates that PET/CT can simplify and perhaps even improve the accuracy of the current staging procedure in SCLC. A larger clinical trial, preferably with consequent histological confirmation in case of discordance, however, is warranted. |
| doi_str_mv | 10.1093/annonc/mdl374 |
| format | Article |
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Patients and methods: A prospective study was designed to examine the role of combined positron emission tomography/computed tomography (PET/CT) compared with standard staging (CT, bone scintigraphy and immunocytochemical assessment of bone marrow biopsy) of patients with SCLC. Thirty-four consecutive patients were included. Twenty-nine patients received initial PET/CT.
Results: PET/CT caused change of stage in 5/29 (17%). Excluding patients with unconfirmed findings or pleural effusion, the sensitivity for accurate staging of patients with extensive disease was the following: for standard staging 79%, PET 93% and PET/CT 93%. Specificity was 100%, 83% and 100%, respectively.
Conclusion: The results from this first study on PET/CT in SCLC indicates that PET/CT can simplify and perhaps even improve the accuracy of the current staging procedure in SCLC. A larger clinical trial, preferably with consequent histological confirmation in case of discordance, however, is warranted.</description><identifier>ISSN: 0923-7534</identifier><identifier>EISSN: 1569-8041</identifier><identifier>DOI: 10.1093/annonc/mdl374</identifier><identifier>PMID: 17060487</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Aged ; Antineoplastic agents ; Biological and medical sciences ; bone marrow ; Bone Marrow - pathology ; Bone Neoplasms - diagnostic imaging ; Bone Neoplasms - secondary ; bone scintigraphy ; Carcinoma, Small Cell - diagnostic imaging ; Carcinoma, Small Cell - pathology ; diagnostic accuracy ; Female ; Fluorodeoxyglucose F18 ; Humans ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - pathology ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging ; PET/CT ; Pharmacology. Drug treatments ; Pneumology ; Positron-Emission Tomography ; Prospective Studies ; Radiopharmaceuticals ; Sensitivity and Specificity ; small-cell lung cancer ; staging ; Tomography, X-Ray Computed ; Tumors of the respiratory system and mediastinum</subject><ispartof>Annals of oncology, 2007-02, Vol.18 (2), p.338-345</ispartof><rights>2007 European Society for Medical Oncology</rights><rights>2007 INIST-CNRS</rights><rights>Copyright Springer Science & Business Media Feb 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-6001fd0b9198a8ba0fb0108124c12648f61a244eb3f94629307e9d02dbe814fd3</citedby><cites>FETCH-LOGICAL-c504t-6001fd0b9198a8ba0fb0108124c12648f61a244eb3f94629307e9d02dbe814fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18550864$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17060487$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fischer, B.M.</creatorcontrib><creatorcontrib>Mortensen, J.</creatorcontrib><creatorcontrib>Langer, S.W.</creatorcontrib><creatorcontrib>Loft, A.</creatorcontrib><creatorcontrib>Berthelsen, A.K.</creatorcontrib><creatorcontrib>Petersen, B.L.</creatorcontrib><creatorcontrib>Daugaard, G.</creatorcontrib><creatorcontrib>Lassen, U.</creatorcontrib><creatorcontrib>Hansen, H.H.</creatorcontrib><title>A prospective study of PET/CT in initial staging of small-cell lung cancer: comparison with CT, bone scintigraphy and bone marrow analysis</title><title>Annals of oncology</title><addtitle>Ann Oncol</addtitle><description>Background: Small-cell lung cancer (SCLC) accounts for 15%–20% of all lung cancer cases. Accurate and fast staging is mandatory when choosing treatment, but current staging procedures are time consuming and lack sensitivity.
Patients and methods: A prospective study was designed to examine the role of combined positron emission tomography/computed tomography (PET/CT) compared with standard staging (CT, bone scintigraphy and immunocytochemical assessment of bone marrow biopsy) of patients with SCLC. Thirty-four consecutive patients were included. Twenty-nine patients received initial PET/CT.
Results: PET/CT caused change of stage in 5/29 (17%). Excluding patients with unconfirmed findings or pleural effusion, the sensitivity for accurate staging of patients with extensive disease was the following: for standard staging 79%, PET 93% and PET/CT 93%. Specificity was 100%, 83% and 100%, respectively.
Conclusion: The results from this first study on PET/CT in SCLC indicates that PET/CT can simplify and perhaps even improve the accuracy of the current staging procedure in SCLC. A larger clinical trial, preferably with consequent histological confirmation in case of discordance, however, is warranted.</description><subject>Aged</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>bone marrow</subject><subject>Bone Marrow - pathology</subject><subject>Bone Neoplasms - diagnostic imaging</subject><subject>Bone Neoplasms - secondary</subject><subject>bone scintigraphy</subject><subject>Carcinoma, Small Cell - diagnostic imaging</subject><subject>Carcinoma, Small Cell - pathology</subject><subject>diagnostic accuracy</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>PET/CT</subject><subject>Pharmacology. Drug treatments</subject><subject>Pneumology</subject><subject>Positron-Emission Tomography</subject><subject>Prospective Studies</subject><subject>Radiopharmaceuticals</subject><subject>Sensitivity and Specificity</subject><subject>small-cell lung cancer</subject><subject>staging</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0923-7534</issn><issn>1569-8041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFklGL1DAQgIso3nr66KsEQZ-sN2nSNPHtWE5POXGFFcSXkKbpXs42XZP2zv0L_mpn6eKCIEIgZOZjkpkvWfaUwmsKip2ZEIZgz_qmYxW_ly1oKVQugdP72QJUwfKqZPwke5TSDQAIVaiH2QmtQACX1SL7dU62cUhbZ0d_60gap2ZHhpasLtZnyzXxAZcfvekwZTY-bPbJ1Juuy63rOtJNGLImWBffEDv0WxN9GgK58-M1Wa5fkXoIWNb6MPpNNNvrHTGhmaO9iXG4w7Ppdsmnx9mD1nTJPTnsp9mXtxfr5WV-9end--X5VW5L4GMuAGjbQK2okkbWBtoaKEhacEsLwWUrqCk4dzVrFReFYlA51UDR1E5S3jbsNHs518XGf0wujbr3ad-MCW6YkhZSScqq4r8gVThrKSWCz_8Cb4YpYlt7RuCbgDGE8hmyOO8UXau30eMIdpqC3qvUs0o9q0T-2aHoVPeuOdIHdwi8OAAmWdO1ES34dORkWYIU_HixT6P7-Sdv4nctKlaV-vLrN81XUn34KFf6M_LVzDuUcOtd1KjPoeHGR_wmuhn8P578G3uIy58</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>Fischer, B.M.</creator><creator>Mortensen, J.</creator><creator>Langer, S.W.</creator><creator>Loft, A.</creator><creator>Berthelsen, A.K.</creator><creator>Petersen, B.L.</creator><creator>Daugaard, G.</creator><creator>Lassen, U.</creator><creator>Hansen, H.H.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20070201</creationdate><title>A prospective study of PET/CT in initial staging of small-cell lung cancer: comparison with CT, bone scintigraphy and bone marrow analysis</title><author>Fischer, B.M. ; Mortensen, J. ; Langer, S.W. ; Loft, A. ; Berthelsen, A.K. ; Petersen, B.L. ; Daugaard, G. ; Lassen, U. ; Hansen, H.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-6001fd0b9198a8ba0fb0108124c12648f61a244eb3f94629307e9d02dbe814fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>bone marrow</topic><topic>Bone Marrow - pathology</topic><topic>Bone Neoplasms - diagnostic imaging</topic><topic>Bone Neoplasms - secondary</topic><topic>bone scintigraphy</topic><topic>Carcinoma, Small Cell - diagnostic imaging</topic><topic>Carcinoma, Small Cell - pathology</topic><topic>diagnostic accuracy</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>PET/CT</topic><topic>Pharmacology. Drug treatments</topic><topic>Pneumology</topic><topic>Positron-Emission Tomography</topic><topic>Prospective Studies</topic><topic>Radiopharmaceuticals</topic><topic>Sensitivity and Specificity</topic><topic>small-cell lung cancer</topic><topic>staging</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fischer, B.M.</creatorcontrib><creatorcontrib>Mortensen, J.</creatorcontrib><creatorcontrib>Langer, S.W.</creatorcontrib><creatorcontrib>Loft, A.</creatorcontrib><creatorcontrib>Berthelsen, A.K.</creatorcontrib><creatorcontrib>Petersen, B.L.</creatorcontrib><creatorcontrib>Daugaard, G.</creatorcontrib><creatorcontrib>Lassen, U.</creatorcontrib><creatorcontrib>Hansen, H.H.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fischer, B.M.</au><au>Mortensen, J.</au><au>Langer, S.W.</au><au>Loft, A.</au><au>Berthelsen, A.K.</au><au>Petersen, B.L.</au><au>Daugaard, G.</au><au>Lassen, U.</au><au>Hansen, H.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A prospective study of PET/CT in initial staging of small-cell lung cancer: comparison with CT, bone scintigraphy and bone marrow analysis</atitle><jtitle>Annals of oncology</jtitle><addtitle>Ann Oncol</addtitle><date>2007-02-01</date><risdate>2007</risdate><volume>18</volume><issue>2</issue><spage>338</spage><epage>345</epage><pages>338-345</pages><issn>0923-7534</issn><eissn>1569-8041</eissn><abstract>Background: Small-cell lung cancer (SCLC) accounts for 15%–20% of all lung cancer cases. Accurate and fast staging is mandatory when choosing treatment, but current staging procedures are time consuming and lack sensitivity.
Patients and methods: A prospective study was designed to examine the role of combined positron emission tomography/computed tomography (PET/CT) compared with standard staging (CT, bone scintigraphy and immunocytochemical assessment of bone marrow biopsy) of patients with SCLC. Thirty-four consecutive patients were included. Twenty-nine patients received initial PET/CT.
Results: PET/CT caused change of stage in 5/29 (17%). Excluding patients with unconfirmed findings or pleural effusion, the sensitivity for accurate staging of patients with extensive disease was the following: for standard staging 79%, PET 93% and PET/CT 93%. Specificity was 100%, 83% and 100%, respectively.
Conclusion: The results from this first study on PET/CT in SCLC indicates that PET/CT can simplify and perhaps even improve the accuracy of the current staging procedure in SCLC. A larger clinical trial, preferably with consequent histological confirmation in case of discordance, however, is warranted.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17060487</pmid><doi>10.1093/annonc/mdl374</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Antineoplastic agents Biological and medical sciences bone marrow Bone Marrow - pathology Bone Neoplasms - diagnostic imaging Bone Neoplasms - secondary bone scintigraphy Carcinoma, Small Cell - diagnostic imaging Carcinoma, Small Cell - pathology diagnostic accuracy Female Fluorodeoxyglucose F18 Humans Lung Neoplasms - diagnostic imaging Lung Neoplasms - pathology Male Medical sciences Middle Aged Neoplasm Staging PET/CT Pharmacology. Drug treatments Pneumology Positron-Emission Tomography Prospective Studies Radiopharmaceuticals Sensitivity and Specificity small-cell lung cancer staging Tomography, X-Ray Computed Tumors of the respiratory system and mediastinum |
| title | A prospective study of PET/CT in initial staging of small-cell lung cancer: comparison with CT, bone scintigraphy and bone marrow analysis |
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