The new 2,3-benzodiazepine derivative EGIS-8332 inhibits AMPA/kainate ion channels and cell death

We observed in vitro neuroprotective and AMPA/kainate receptor antagonist effects of the new 2,3-benzodiazepine derivative EGIS-8332 ( R, S-1-(4-aminophenyl)-7,8-methylenedioxy-4-cyano-4-methyl-3- N-acetyl-5 H-3,4-dihydro-2,3-benzodiazepine) using the lactate dehydrogenase (LDH) release assay and pa...

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Veröffentlicht in:	Neurochemistry international 2007-02, Vol.50 (3), p.555-563
Hauptverfasser:	Vegh, Miklos G., Kovács, Attila D., Kovács, Gábor, Szabó, Géza, Tihanyi, Károly, Hársing, László G., Lévay, György
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology AMPA Animals Benzodiazepine Benzodiazepines - pharmacology Biological and medical sciences Cell Death - drug effects Cells, Cultured Excitatory Amino Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology GluR1 Kainate Male Neurons - drug effects Neuroprotection NMDA Primary neuronal culture Purkinje neuron Quisqualic Acid - pharmacology Rats Rats, Wistar Receptors, AMPA - antagonists & inhibitors Receptors, Kainic Acid - antagonists & inhibitors Stereoisomerism Stereoselectivity Telencephalon - cytology Telencephalon - drug effects Vertebrates: nervous system and sense organs
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