Influence of CYP3A5 genetic polymorphism on cyclosporine A metabolism and elimination in Chinese renal transplant recipients

Aim： To investigate whether the CYP3A5＊3 polymorphism would affect cyclosporine A （CsA） metabolism in Chinese renal transplant patients. Methods： The CYP3A5＊3 genotype was determined in Chinese renal transplant recipients using polymerase chain reaction and amplification of specific alleles （PCR-ASA...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta pharmacologica Sinica 2006-11, Vol.27 (11), p.1504-1508
Hauptverfasser:	CHU, Xiao‐man, HAO, Hai‐ping, WANG, Guang‐ji, GUO, Lian‐qing, MIN, Pei‐qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Asian Continental Ancestry Group China cyclosporine Cyclosporine - metabolism CYP3A5 Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - genetics DNA Primers Female genetic polymorphism Genotype Humans Kidney Transplantation Male metabolic ratio Middle Aged Polymorphism, Genetic renal transplant patients 新陈代谢环孢霉素遗传多态性
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!