Ultra-performance liquid chromatography/time-of-flight mass spectrometry based metabolomics of raw and steamed Panax notoginseng
At present, metabolite profiling is of growing importance in herbal medicine fields such as breeding, formulation, quality control and clinical trials. This preliminary study indicated that ultra‐performance liquid chromatography/time‐of‐flight mass spectrometry (UPLC/TOFMS)‐based metabolomics allow...
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| Veröffentlicht in: | Rapid communications in mass spectrometry 2007-01, Vol.21 (4), p.519-528 |
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| container_title | Rapid communications in mass spectrometry |
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| creator | Chan, Eric C. Y. Yap, Swee-Lee Lau, Aik-Jiang Leow, Pay-Chin Toh, Ding-Fung Koh, Hwee-Ling |
| description | At present, metabolite profiling is of growing importance in herbal medicine fields such as breeding, formulation, quality control and clinical trials. This preliminary study indicated that ultra‐performance liquid chromatography/time‐of‐flight mass spectrometry (UPLC/TOFMS)‐based metabolomics allows direct detection of down‐stream derivatives of metabolites, arising from the herbal formulation process. This analytical approach allows the discrimination and tentative authentication of unique biomarkers related to different herbal extracts using unsupervised multivariate principal component analysis (PCA). The tentative identification of biomarkers is complemented significantly by the accurate mass measurement of TOFMS and the high resolution and high retention time reproducibility rendered by UPLC. The application of this approach in herbal extract discrimination and ginsenoside biomarker discovery of raw and steamed Panax notoginseng (Burk.) F.H. Chen is demonstrated and discussed. Copyright © 2007 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/rcm.2864 |
| format | Article |
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This analytical approach allows the discrimination and tentative authentication of unique biomarkers related to different herbal extracts using unsupervised multivariate principal component analysis (PCA). The tentative identification of biomarkers is complemented significantly by the accurate mass measurement of TOFMS and the high resolution and high retention time reproducibility rendered by UPLC. The application of this approach in herbal extract discrimination and ginsenoside biomarker discovery of raw and steamed Panax notoginseng (Burk.) F.H. Chen is demonstrated and discussed. Copyright © 2007 John Wiley & Sons, Ltd.</description><subject>Chromatography, High Pressure Liquid</subject><subject>Cooking</subject><subject>Hot Temperature</subject><subject>Metabolic Networks and Pathways</subject><subject>Panax notoginseng - chemistry</subject><subject>Panax notoginseng - metabolism</subject><subject>Plant Extracts - chemistry</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><issn>0951-4198</issn><issn>1097-0231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MFu1DAUhWELgehQkHgC5BVik9aOk9hZwqgtiBYKourSurGvZwxJnNoZtbPj0XE1EaxY2ZI_Hck_Ia85O-GMlafRDCelaqonZMVZKwtWCv6UrFhb86LirToiL1L6yRjndcmekyMuS6FKXq3I75t-jlBMGF2IA4wGae_vdt5Ss41hgDlsIkzb_ensByyCK1zvN9uZDpASTROaOSuc4552kNDSfIcu9GHwJtHgaIR7CqOlaUYY8vs1jPBAx5B3_Zhw3Lwkzxz0CV8t5zG5OT_7sf5YXH69-LR-f1mYqhRVoazlClpbIWtcg62SNRiuUPBKNLZyUqJgVnZd5xh2FRiZYc2YU7WzrWrEMXl72J1iuNthmvXgk8G-hxHDLulGtVIppjJ8d4AmhpQiOj1FP0Dca870Y22da-vH2pm-WTZ3Xf7cP7jkzaA4gHvf4_6_Q_r7-moZXLzPvR7-eoi_dCOFrPXtlwv97ba8_nB-9VlL8QckApuD</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Chan, Eric C. 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Y.</creatorcontrib><creatorcontrib>Yap, Swee-Lee</creatorcontrib><creatorcontrib>Lau, Aik-Jiang</creatorcontrib><creatorcontrib>Leow, Pay-Chin</creatorcontrib><creatorcontrib>Toh, Ding-Fung</creatorcontrib><creatorcontrib>Koh, Hwee-Ling</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Rapid communications in mass spectrometry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chan, Eric C. Y.</au><au>Yap, Swee-Lee</au><au>Lau, Aik-Jiang</au><au>Leow, Pay-Chin</au><au>Toh, Ding-Fung</au><au>Koh, Hwee-Ling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultra-performance liquid chromatography/time-of-flight mass spectrometry based metabolomics of raw and steamed Panax notoginseng</atitle><jtitle>Rapid communications in mass spectrometry</jtitle><addtitle>Rapid Commun. Mass Spectrom</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>21</volume><issue>4</issue><spage>519</spage><epage>528</epage><pages>519-528</pages><issn>0951-4198</issn><eissn>1097-0231</eissn><abstract>At present, metabolite profiling is of growing importance in herbal medicine fields such as breeding, formulation, quality control and clinical trials. 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Copyright © 2007 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>17238214</pmid><doi>10.1002/rcm.2864</doi><tpages>10</tpages></addata></record> |
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| ispartof | Rapid communications in mass spectrometry, 2007-01, Vol.21 (4), p.519-528 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Chromatography, High Pressure Liquid Cooking Hot Temperature Metabolic Networks and Pathways Panax notoginseng - chemistry Panax notoginseng - metabolism Plant Extracts - chemistry Spectrometry, Mass, Electrospray Ionization |
| title | Ultra-performance liquid chromatography/time-of-flight mass spectrometry based metabolomics of raw and steamed Panax notoginseng |
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