Efficacy of once-daily esomeprazole treatment in patients with laryngopharyngeal reflux evaluated by 24-hour pH monitoring
Laryngopharyngeal reflux (LPR) is generally treated with twice-daily proton-pump inhibitor (PPI) therapy. In this study, the efficacy of esomeprazole 40 mg once-daily together with lifestyle modifications was determined by repeated 24-hour pH monitoring. A prospective study. Forty-nine patients with...
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| Veröffentlicht in: | Otolaryngology-head and neck surgery 2007-02, Vol.136 (2), p.205-210 |
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| creator | Reichel, Oliver Keller, Jeanette Rasp, Gerd Hagedorn, Hjalmar Berghaus, Alexander |
| description | Laryngopharyngeal reflux (LPR) is generally treated with twice-daily proton-pump inhibitor (PPI) therapy. In this study, the efficacy of esomeprazole 40 mg once-daily together with lifestyle modifications was determined by repeated 24-hour pH monitoring.
A prospective study. Forty-nine patients with suspected LPR underwent 24-hour pH monitoring. Twenty-seven of 49 patients with measurable abnormal proximal reflux reflected by a reflux area index (RAI) >6.3 were treated with esomeprazole 40 mg every day, and a second pH study was performed.
In 22 of 27 patients, everyday PPI treatment reduced the RAI. Four of 5 patients with no RAI reduction reported on symptomatic relief.
In a considerable number of patients with suspected LPR, pH monitoring reveals no abnormal proximal reflux. Esomeprazole 40 mg every day together with lifestyle modifications could reach adequate acid suppression in a large number of patients. Symptom improvement is also reported by patients without measurable effects of therapy. |
| doi_str_mv | 10.1016/j.otohns.2006.10.011 |
| format | Article |
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A prospective study. Forty-nine patients with suspected LPR underwent 24-hour pH monitoring. Twenty-seven of 49 patients with measurable abnormal proximal reflux reflected by a reflux area index (RAI) >6.3 were treated with esomeprazole 40 mg every day, and a second pH study was performed.
In 22 of 27 patients, everyday PPI treatment reduced the RAI. Four of 5 patients with no RAI reduction reported on symptomatic relief.
In a considerable number of patients with suspected LPR, pH monitoring reveals no abnormal proximal reflux. Esomeprazole 40 mg every day together with lifestyle modifications could reach adequate acid suppression in a large number of patients. Symptom improvement is also reported by patients without measurable effects of therapy.</description><identifier>ISSN: 0194-5998</identifier><identifier>EISSN: 1097-6817</identifier><identifier>DOI: 10.1016/j.otohns.2006.10.011</identifier><identifier>PMID: 17275540</identifier><language>eng</language><publisher>Los Angeles, CA: Mosby, Inc</publisher><subject>Adult ; Aged, 80 and over ; Enzyme Inhibitors - therapeutic use ; Esomeprazole - therapeutic use ; Female ; Fundoplication ; Humans ; Hydrogen-Ion Concentration ; Hypopharynx ; Life Style ; Male ; Middle Aged ; Monitoring, Ambulatory ; Pharyngeal Diseases - drug therapy</subject><ispartof>Otolaryngology-head and neck surgery, 2007-02, Vol.136 (2), p.205-210</ispartof><rights>2007 American Academy of Otolaryngology–Head and Neck Surgery Foundation</rights><rights>2007 SAGE Publications</rights><rights>2007 American Association of Otolaryngology‐Head and Neck Surgery Foundation (AAO‐HNSF)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4554-f3eb7ac2439d73ceb63b061a4f4f4ff985e7d09026ec0f9f77d9c8e748e25ea03</citedby><cites>FETCH-LOGICAL-c4554-f3eb7ac2439d73ceb63b061a4f4f4ff985e7d09026ec0f9f77d9c8e748e25ea03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1016/j.otohns.2006.10.011$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1016/j.otohns.2006.10.011$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,1411,21799,27903,27904,43600,43601,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17275540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reichel, Oliver</creatorcontrib><creatorcontrib>Keller, Jeanette</creatorcontrib><creatorcontrib>Rasp, Gerd</creatorcontrib><creatorcontrib>Hagedorn, Hjalmar</creatorcontrib><creatorcontrib>Berghaus, Alexander</creatorcontrib><title>Efficacy of once-daily esomeprazole treatment in patients with laryngopharyngeal reflux evaluated by 24-hour pH monitoring</title><title>Otolaryngology-head and neck surgery</title><addtitle>Otolaryngol Head Neck Surg</addtitle><description>Laryngopharyngeal reflux (LPR) is generally treated with twice-daily proton-pump inhibitor (PPI) therapy. In this study, the efficacy of esomeprazole 40 mg once-daily together with lifestyle modifications was determined by repeated 24-hour pH monitoring.
A prospective study. Forty-nine patients with suspected LPR underwent 24-hour pH monitoring. Twenty-seven of 49 patients with measurable abnormal proximal reflux reflected by a reflux area index (RAI) >6.3 were treated with esomeprazole 40 mg every day, and a second pH study was performed.
In 22 of 27 patients, everyday PPI treatment reduced the RAI. Four of 5 patients with no RAI reduction reported on symptomatic relief.
In a considerable number of patients with suspected LPR, pH monitoring reveals no abnormal proximal reflux. Esomeprazole 40 mg every day together with lifestyle modifications could reach adequate acid suppression in a large number of patients. Symptom improvement is also reported by patients without measurable effects of therapy.</description><subject>Adult</subject><subject>Aged, 80 and over</subject><subject>Enzyme Inhibitors - therapeutic use</subject><subject>Esomeprazole - therapeutic use</subject><subject>Female</subject><subject>Fundoplication</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hypopharynx</subject><subject>Life Style</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monitoring, Ambulatory</subject><subject>Pharyngeal Diseases - drug therapy</subject><issn>0194-5998</issn><issn>1097-6817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU-LFDEQxYMo7rj6DURy8tZj0v_SARF02XWExb3oOaTTlZkM6aRN0rv2fnoz9oA3lRwqFO89qn6F0GtKtpTQ9t1x65M_uLgtCWlza0sofYI2lHBWtB1lT9GGUF4XDefdBXoR45FkYcvYc3RBWcmapiYb9HittVFSLdhr7J2CYpDGLhiiH2EK8tFbwCmATCO4hI3Dk0wmfyN-MOmArQyL2_vp8LuCtDiAtvNPDPfSzjLBgPsFl3Vx8HPA0w6P3pnkg3H7l-iZljbCq3O9RN9vrr9d7Yrbu89frj7eFqrOMxa6gp5JVdYVH1iloG-rnrRU1vr0NO8aYAPhpGxBEc01YwNXHbC6g7IBSapL9HbNnYL_MUNMYjRRgbXSgZ-jaDvOuoo3WVivQhV8jHkPMQUz5sUEJeLEXBzFylycmJ-6mXm2vTnnz_0Iwx_TGXIWvF8FD8bC8l-h4m739dNNSRips52u9ij3II6Zo8u4_jXTh9UDGey9gSCiyldTMJgAKonBm78H_AKS0rrE</recordid><startdate>200702</startdate><enddate>200702</enddate><creator>Reichel, Oliver</creator><creator>Keller, Jeanette</creator><creator>Rasp, Gerd</creator><creator>Hagedorn, Hjalmar</creator><creator>Berghaus, Alexander</creator><general>Mosby, Inc</general><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200702</creationdate><title>Efficacy of once-daily esomeprazole treatment in patients with laryngopharyngeal reflux evaluated by 24-hour pH monitoring</title><author>Reichel, Oliver ; Keller, Jeanette ; Rasp, Gerd ; Hagedorn, Hjalmar ; Berghaus, Alexander</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4554-f3eb7ac2439d73ceb63b061a4f4f4ff985e7d09026ec0f9f77d9c8e748e25ea03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged, 80 and over</topic><topic>Enzyme Inhibitors - therapeutic use</topic><topic>Esomeprazole - therapeutic use</topic><topic>Female</topic><topic>Fundoplication</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hypopharynx</topic><topic>Life Style</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Monitoring, Ambulatory</topic><topic>Pharyngeal Diseases - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reichel, Oliver</creatorcontrib><creatorcontrib>Keller, Jeanette</creatorcontrib><creatorcontrib>Rasp, Gerd</creatorcontrib><creatorcontrib>Hagedorn, Hjalmar</creatorcontrib><creatorcontrib>Berghaus, Alexander</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Otolaryngology-head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reichel, Oliver</au><au>Keller, Jeanette</au><au>Rasp, Gerd</au><au>Hagedorn, Hjalmar</au><au>Berghaus, Alexander</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of once-daily esomeprazole treatment in patients with laryngopharyngeal reflux evaluated by 24-hour pH monitoring</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><addtitle>Otolaryngol Head Neck Surg</addtitle><date>2007-02</date><risdate>2007</risdate><volume>136</volume><issue>2</issue><spage>205</spage><epage>210</epage><pages>205-210</pages><issn>0194-5998</issn><eissn>1097-6817</eissn><abstract>Laryngopharyngeal reflux (LPR) is generally treated with twice-daily proton-pump inhibitor (PPI) therapy. In this study, the efficacy of esomeprazole 40 mg once-daily together with lifestyle modifications was determined by repeated 24-hour pH monitoring.
A prospective study. Forty-nine patients with suspected LPR underwent 24-hour pH monitoring. Twenty-seven of 49 patients with measurable abnormal proximal reflux reflected by a reflux area index (RAI) >6.3 were treated with esomeprazole 40 mg every day, and a second pH study was performed.
In 22 of 27 patients, everyday PPI treatment reduced the RAI. Four of 5 patients with no RAI reduction reported on symptomatic relief.
In a considerable number of patients with suspected LPR, pH monitoring reveals no abnormal proximal reflux. Esomeprazole 40 mg every day together with lifestyle modifications could reach adequate acid suppression in a large number of patients. Symptom improvement is also reported by patients without measurable effects of therapy.</abstract><cop>Los Angeles, CA</cop><pub>Mosby, Inc</pub><pmid>17275540</pmid><doi>10.1016/j.otohns.2006.10.011</doi><tpages>6</tpages></addata></record> |
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| ispartof | Otolaryngology-head and neck surgery, 2007-02, Vol.136 (2), p.205-210 |
| issn | 0194-5998 1097-6817 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; SAGE Complete A-Z List; Alma/SFX Local Collection |
| subjects | Adult Aged, 80 and over Enzyme Inhibitors - therapeutic use Esomeprazole - therapeutic use Female Fundoplication Humans Hydrogen-Ion Concentration Hypopharynx Life Style Male Middle Aged Monitoring, Ambulatory Pharyngeal Diseases - drug therapy |
| title | Efficacy of once-daily esomeprazole treatment in patients with laryngopharyngeal reflux evaluated by 24-hour pH monitoring |
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