Clinical relevance of intra-operative sentinel lymph node examination in breast cancer management
To determine the sensitivity, accuracy, and clinical relevance of intra-operative examination of sentinel lymph nodes in breast cancer management. Retrospective study. Private anatomical pathology practice. Three hundred breast cancer patients who underwent axillary sentinel lymph node biopsies for...
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| Veröffentlicht in: | Hong Kong medical journal = Xianggang yi xue za zhi 2007-02, Vol.13 (1), p.8-11 |
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| container_title | Hong Kong medical journal = Xianggang yi xue za zhi |
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| creator | Leung, K M Chan, K W Yeoh, Gary P S Chan, John K C Cheung, Polly S Y |
| description | To determine the sensitivity, accuracy, and clinical relevance of intra-operative examination of sentinel lymph nodes in breast cancer management.
Retrospective study.
Private anatomical pathology practice.
Three hundred breast cancer patients who underwent axillary sentinel lymph node biopsies for intra-operative assessment between January 2004 and March 2006.
Correct identification of metastatic carcinoma in sentinel lymph nodes during intra-operative examination, sparing patient a second surgery.
The intra-operative diagnosis of sentinel lymph node biopsies from 300 consecutive patients were compared with the final pathological diagnoses. The final pathology results showed metastatic carcinoma in 74 patients, of whom 63 (85%) were correctly diagnosed during frozen section examination. There was no false-positive case (positive predictive value 100%). The sensitivity for detecting macro- and micro-metastases were 95% and 50%, respectively (P |
| format | Article |
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Retrospective study.
Private anatomical pathology practice.
Three hundred breast cancer patients who underwent axillary sentinel lymph node biopsies for intra-operative assessment between January 2004 and March 2006.
Correct identification of metastatic carcinoma in sentinel lymph nodes during intra-operative examination, sparing patient a second surgery.
The intra-operative diagnosis of sentinel lymph node biopsies from 300 consecutive patients were compared with the final pathological diagnoses. The final pathology results showed metastatic carcinoma in 74 patients, of whom 63 (85%) were correctly diagnosed during frozen section examination. There was no false-positive case (positive predictive value 100%). The sensitivity for detecting macro- and micro-metastases were 95% and 50%, respectively (P<0.01). The sensitivity for detecting metastases in T1 and T2/above tumours were 72% and 90%, respectively (P<0.05).
Intra-operative examination is a reliable and sensitive method for the detection of sentinel lymph node metastasis. Eighty-five percent of the patients with metastatic disease were correctly diagnosed and spared a second operation for axillary dissection. The disadvantage of missing a positive lymph node is by far outweighed by the advantage of a single stage operation in case of a positive diagnosis. The benefit of intra-operative examination was slightly less in patients with smaller tumours.</description><identifier>ISSN: 1024-2708</identifier><identifier>EISSN: 2226-8707</identifier><identifier>PMID: 17277385</identifier><language>eng</language><publisher>China: Hong Kong Academy of Medicine</publisher><subject>Biopsy ; Breast cancer ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; Carcinoma in Situ - pathology ; Carcinoma in Situ - surgery ; Carcinoma, Ductal, Breast - pathology ; Carcinoma, Ductal, Breast - surgery ; Female ; Frozen Sections ; Humans ; Intraoperative Care ; Lymphatic Metastasis - diagnosis ; Lymphatic system ; Metastasis ; Pathology ; Predictive Value of Tests ; Retrospective Studies ; Sensitivity and Specificity ; Sentinel Lymph Node Biopsy</subject><ispartof>Hong Kong medical journal = Xianggang yi xue za zhi, 2007-02, Vol.13 (1), p.8-11</ispartof><rights>2007. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://www.hkmj.org/about/website.html</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17277385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leung, K M</creatorcontrib><creatorcontrib>Chan, K W</creatorcontrib><creatorcontrib>Yeoh, Gary P S</creatorcontrib><creatorcontrib>Chan, John K C</creatorcontrib><creatorcontrib>Cheung, Polly S Y</creatorcontrib><title>Clinical relevance of intra-operative sentinel lymph node examination in breast cancer management</title><title>Hong Kong medical journal = Xianggang yi xue za zhi</title><addtitle>Hong Kong Med J</addtitle><description>To determine the sensitivity, accuracy, and clinical relevance of intra-operative examination of sentinel lymph nodes in breast cancer management.
Retrospective study.
Private anatomical pathology practice.
Three hundred breast cancer patients who underwent axillary sentinel lymph node biopsies for intra-operative assessment between January 2004 and March 2006.
Correct identification of metastatic carcinoma in sentinel lymph nodes during intra-operative examination, sparing patient a second surgery.
The intra-operative diagnosis of sentinel lymph node biopsies from 300 consecutive patients were compared with the final pathological diagnoses. The final pathology results showed metastatic carcinoma in 74 patients, of whom 63 (85%) were correctly diagnosed during frozen section examination. There was no false-positive case (positive predictive value 100%). The sensitivity for detecting macro- and micro-metastases were 95% and 50%, respectively (P<0.01). The sensitivity for detecting metastases in T1 and T2/above tumours were 72% and 90%, respectively (P<0.05).
Intra-operative examination is a reliable and sensitive method for the detection of sentinel lymph node metastasis. Eighty-five percent of the patients with metastatic disease were correctly diagnosed and spared a second operation for axillary dissection. The disadvantage of missing a positive lymph node is by far outweighed by the advantage of a single stage operation in case of a positive diagnosis. The benefit of intra-operative examination was slightly less in patients with smaller tumours.</description><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - surgery</subject><subject>Carcinoma in Situ - pathology</subject><subject>Carcinoma in Situ - surgery</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Carcinoma, Ductal, Breast - surgery</subject><subject>Female</subject><subject>Frozen Sections</subject><subject>Humans</subject><subject>Intraoperative Care</subject><subject>Lymphatic Metastasis - diagnosis</subject><subject>Lymphatic system</subject><subject>Metastasis</subject><subject>Pathology</subject><subject>Predictive Value of Tests</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Sentinel Lymph Node Biopsy</subject><issn>1024-2708</issn><issn>2226-8707</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkEtLxDAUhYMozjj6FyQguCvk0Ty6lMEXDLjRdblt72iGNK1JOzj_3ojjxrs5i_udw-GckKUQQhfWMHNKlpyJshCG2QW5SGnHmLCqYudkwY0wRlq1JLD2LrgWPI3ocQ-hRTpsqQtThGIYMcLk9kgThskF9NQf-vGDhqFDil_Qu5D_Q8g8bSJCmmj7ExFpDwHesc-2S3K2BZ_w6qgr8vZw_7p-KjYvj8_ru00xciWmQlswDbesQ96pptFNpbetklqXVcekQVGiqloFcpuPiw6bErTqLK8kK0EYuSK3v7ljHD5nTFPdu9Si9xBwmFOtbWUsFyqDN__A3TDHkLvVwti8jGRWZOr6SM1Nj109RtdDPNR_08lvJ91sSg</recordid><startdate>200702</startdate><enddate>200702</enddate><creator>Leung, K M</creator><creator>Chan, K W</creator><creator>Yeoh, Gary P S</creator><creator>Chan, John K C</creator><creator>Cheung, Polly S Y</creator><general>Hong Kong Academy of Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BVBZV</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200702</creationdate><title>Clinical relevance of intra-operative sentinel lymph node examination in breast cancer management</title><author>Leung, K M ; Chan, K W ; Yeoh, Gary P S ; Chan, John K C ; Cheung, Polly S Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p152t-68a7b180de1d5bb6b96fc536649d037e24e59c5a3ffff12deb4a65d819304a273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biopsy</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - surgery</topic><topic>Carcinoma in Situ - pathology</topic><topic>Carcinoma in Situ - surgery</topic><topic>Carcinoma, Ductal, Breast - pathology</topic><topic>Carcinoma, Ductal, Breast - surgery</topic><topic>Female</topic><topic>Frozen Sections</topic><topic>Humans</topic><topic>Intraoperative Care</topic><topic>Lymphatic Metastasis - diagnosis</topic><topic>Lymphatic system</topic><topic>Metastasis</topic><topic>Pathology</topic><topic>Predictive Value of Tests</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Sentinel Lymph Node Biopsy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leung, K M</creatorcontrib><creatorcontrib>Chan, K W</creatorcontrib><creatorcontrib>Yeoh, Gary P S</creatorcontrib><creatorcontrib>Chan, John K C</creatorcontrib><creatorcontrib>Cheung, Polly S Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>East & South Asia Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Hong Kong medical journal = Xianggang yi xue za zhi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leung, K M</au><au>Chan, K W</au><au>Yeoh, Gary P S</au><au>Chan, John K C</au><au>Cheung, Polly S Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical relevance of intra-operative sentinel lymph node examination in breast cancer management</atitle><jtitle>Hong Kong medical journal = Xianggang yi xue za zhi</jtitle><addtitle>Hong Kong Med J</addtitle><date>2007-02</date><risdate>2007</risdate><volume>13</volume><issue>1</issue><spage>8</spage><epage>11</epage><pages>8-11</pages><issn>1024-2708</issn><eissn>2226-8707</eissn><abstract>To determine the sensitivity, accuracy, and clinical relevance of intra-operative examination of sentinel lymph nodes in breast cancer management.
Retrospective study.
Private anatomical pathology practice.
Three hundred breast cancer patients who underwent axillary sentinel lymph node biopsies for intra-operative assessment between January 2004 and March 2006.
Correct identification of metastatic carcinoma in sentinel lymph nodes during intra-operative examination, sparing patient a second surgery.
The intra-operative diagnosis of sentinel lymph node biopsies from 300 consecutive patients were compared with the final pathological diagnoses. The final pathology results showed metastatic carcinoma in 74 patients, of whom 63 (85%) were correctly diagnosed during frozen section examination. There was no false-positive case (positive predictive value 100%). The sensitivity for detecting macro- and micro-metastases were 95% and 50%, respectively (P<0.01). The sensitivity for detecting metastases in T1 and T2/above tumours were 72% and 90%, respectively (P<0.05).
Intra-operative examination is a reliable and sensitive method for the detection of sentinel lymph node metastasis. Eighty-five percent of the patients with metastatic disease were correctly diagnosed and spared a second operation for axillary dissection. The disadvantage of missing a positive lymph node is by far outweighed by the advantage of a single stage operation in case of a positive diagnosis. The benefit of intra-operative examination was slightly less in patients with smaller tumours.</abstract><cop>China</cop><pub>Hong Kong Academy of Medicine</pub><pmid>17277385</pmid><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biopsy Breast cancer Breast Neoplasms - pathology Breast Neoplasms - surgery Carcinoma in Situ - pathology Carcinoma in Situ - surgery Carcinoma, Ductal, Breast - pathology Carcinoma, Ductal, Breast - surgery Female Frozen Sections Humans Intraoperative Care Lymphatic Metastasis - diagnosis Lymphatic system Metastasis Pathology Predictive Value of Tests Retrospective Studies Sensitivity and Specificity Sentinel Lymph Node Biopsy |
| title | Clinical relevance of intra-operative sentinel lymph node examination in breast cancer management |
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