A fusion protein of hepatocyte growth factor for immobilization to collagen

Abstract We describe here a fusion protein consisting of hepatocyte growth factor (HGF; an angiogenic factor) and a collagen-binding domain (CBD) polypeptide of fibronectin (FN). This fusion protein (CBD-HGF), produced by a baculovirus expression system, exhibited much stronger collagen binding acti...

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Veröffentlicht in:	Biomaterials 2007-04, Vol.28 (11), p.1989-1997
Hauptverfasser:	Kitajima, Takashi, Terai, Hiroshi, Ito, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Angiogenesis Animals Baculovirus Biocompatible Materials - chemistry Cells, Cultured Collagen Collagen - chemistry Dentistry Dose-Response Relationship, Drug Endothelial cells Endothelial Cells - cytology Endothelial Cells - metabolism Fibronectins - chemistry Growth factors Hepatocyte Growth Factor - metabolism HGF Humans Immobilization Neovascularization, Pathologic Protein Structure, Tertiary Recombinant Fusion Proteins - chemistry Regeneration Time Factors Tissue Engineering - methods
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