Stabilization of phenylalanine ammonia lyase against organic solvent mediated deactivation

A potential novel therapy for phenylketonuria involves oral administration of microencapsulated phenylalanine ammonia lyase (PAL), an enzyme that converts phenylalanine to transcinnamic acid. A drawback of this potential therapy is that encapsulated PAL retains only 23% of its activity. Microcapsule...

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Veröffentlicht in:	International journal of pharmaceutics 2007-02, Vol.331 (1), p.107-115
Hauptverfasser:	Shah, R.M., D’mello, Anil P.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Hydroxypropyl-beta-cyclodextrin Adsorption beta-Cyclodextrins - chemistry Biological and medical sciences Capsules Catalytic activity Chromatography, Gel Cyclodextrins Drug Stability Electrophoresis, Polyacrylamide Gel Emulsion Emulsions Ethanol - chemistry Ether - chemistry Excipients - chemistry gamma-Cyclodextrins - chemistry General pharmacology Glass - chemistry Hemoglobins - chemistry Medical sciences Microcapsule Organic solvents Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phenylalanine ammonia lyase Phenylalanine Ammonia-Lyase - chemistry Solvents - chemistry Tromethamine - chemistry Water - chemistry
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