Regulation of P53 stability in p53 mutated human and mouse hepatoma cells

The tumor suppressor p53 is frequently mutated in cancer. We have investigated the regulation of P53 in p53 wild type mouse hepatoma cells (line 55.1c), in p53 heterozygeously mutated cells (56.1b) and in p53 defective cells (lines 56.1d, 70.4 and HUH7) under various experimental settings. The basal...

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Veröffentlicht in:	International journal of cancer 2007-04, Vol.120 (7), p.1459-1464
Hauptverfasser:	Hailfinger, Stephan, Jaworski, Maike, Marx‐Stoelting, Philip, Wanke, Ines, Schwarz, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Apoptosis - radiation effects Biological and medical sciences Blotting, Western Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism DFX Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic hepatoma cells Humans Immunoprecipitation Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver. Biliary tract. Portal circulation. Exocrine pancreas MDM2 Medical sciences Mice Mutation - genetics p53 mutation Proto-Oncogene Proteins c-mdm2 - genetics Proto-Oncogene Proteins c-mdm2 - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism ROS Tumor Cells, Cultured - metabolism Tumor Cells, Cultured - radiation effects Tumor Suppressor Protein p53 - metabolism Tumors Ultraviolet Rays UV irradiation
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