Ligation of Centrocyte/Centroblast Marker 1 on Epstein-Barr Virus–Transformed B Lymphocytes Induces Cell Death in a Reactive Oxygen Species–Dependent Manner

After primary infection of B cells with Epstein-Barr virus (EBV), infected B cells express several viral homologs of human genes that promote activation (LMP1 and CD40) or survival (BHRF and BCL2). EBV-infected B cells also express germinal center phenotype markers, such as CD77, PNA, CD95, and CD38...

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Veröffentlicht in:	Human Immunology 2006-10, Vol.67 (10), p.795-807
Hauptverfasser:	Kim, Yeong Seok, Park, Ga Bin, Choi, Young Mi, Kwon, Oh Suk, Song, Hyun Keun, Kang, Jae Seung, Kim, Young In, Lee, Wang Jae, Hur, Dae Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Actins - metabolism Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antigens, CD - immunology Antigens, CD - metabolism Antigens, Differentiation, B-Lymphocyte - immunology Antigens, Differentiation, B-Lymphocyte - physiology Antioxidants - pharmacology Apoptosis - drug effects Apoptosis - physiology Apoptosis Inducing Factor - metabolism apoptosis, reactive oxygen species B-Lymphocytes - metabolism B-Lymphocytes - physiology B-Lymphocytes - virology Caspase Inhibitors Caspases - metabolism Cell Nucleus - metabolism Cell Transformation, Viral Cells, Cultured CM1 Cytochalasin D - pharmacology Cytochromes c - metabolism Endodeoxyribonucleases - metabolism Epstein-Barr virus Herpesvirus 4, Human Humans Membrane Potential, Mitochondrial - drug effects Membrane Potential, Mitochondrial - immunology Mitochondria - metabolism Phosphatidylserines - metabolism Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism
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