Low postabsorptive net protein degradation in male cancer patients : Lack of sensitivity to regulatory amino acids?

Autophagic (lysosomal) and proteasomic protein degradation are important regulatory mechanisms in the homeostasis of muscle mass, that may be profoundly disturbed in cancer and other wasting syndromes. Due to the inhibiting effect of amino acids and insulin, net proteolysis is restricted to the fast...

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Veröffentlicht in:	Oncology reports 2007-03, Vol.17 (3), p.695-700
Hauptverfasser:	HOLM, Eggert, HILDEBRANDT, Wulf, KINSCHERF, Ralf, DROGE, Wulf
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - blood Amino Acids - metabolism Autophagy - physiology Biological and medical sciences Cross-Sectional Studies Humans Male Medical sciences Middle Aged Muscle, Skeletal - metabolism Neoplasms - metabolism Proteasome Endopeptidase Complex - physiology Proteins - metabolism Tumors
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