Effect of GNTI, a kappa opioid receptor antagonist, on MK-801-induced hyperlocomotion and stereotypy in mice
Aim： To examine the effect of GNTI [5＇-guanidinyl-17-（cyclopropylmethyl）-6,7- dehydro-4,5ot-epoxy-3,14-dihydroxy-6,7-2＇,3＇-indolomorphinan], a selective antagonist for the kappa opioid receptor, in the MK-801 （dizocilpine maleate）-induced behavioral model of psychosis in schizophrenia as a way to ex...
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| Veröffentlicht in: | Acta pharmacologica Sinica 2006-11, Vol.27 (11), p.1401-1408 |
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| creator | Qi, Chun-ting Zou, Hong Zhang, Chen-hao Xie, Qing-lian Jin, Mei-lei Yu, Lei |
| description | Aim： To examine the effect of GNTI [5＇-guanidinyl-17-（cyclopropylmethyl）-6,7- dehydro-4,5ot-epoxy-3,14-dihydroxy-6,7-2＇,3＇-indolomorphinan], a selective antagonist for the kappa opioid receptor, in the MK-801 （dizocilpine maleate）-induced behavioral model of psychosis in schizophrenia as a way to explore the involvement of the kappa opioid receptor in modulating psychotic symptoms of schizophrenia. Methods： Two doses of MK-801 （0.3 mg/kg and 0.6 mg/kg） were administered by systemic injection in mice to induce psychosis-like behavior as a rodent schizophrenia model, preceded by an injection of different doses of GNTI. Both locomotion and stereotypy were measured as the behavioral endpoints for quantitative analysis. Results： GNTI inhibited MK-801-induced hypeflocomotion and stereotypy. In particular, GNTI showed differential modulation of stereotypy induced by 0.3 mg/kg vs 0.6 mg/kg MK-801. Conclusion： Antagonism of kappa opioid receptors attenuates MK-801-induced behavior, suggesting a potential involvement of the kappa opioid receptor in psychosis-like symptoms of schizophrenia. GNTI appears to be a useful pharmacological tool to explore the kappa opioid receptor function in vivo. |
| doi_str_mv | 10.1111/j.1745-7254.2006.00448.x |
| format | Article |
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Methods： Two doses of MK-801 （0.3 mg/kg and 0.6 mg/kg） were administered by systemic injection in mice to induce psychosis-like behavior as a rodent schizophrenia model, preceded by an injection of different doses of GNTI. Both locomotion and stereotypy were measured as the behavioral endpoints for quantitative analysis. Results： GNTI inhibited MK-801-induced hypeflocomotion and stereotypy. In particular, GNTI showed differential modulation of stereotypy induced by 0.3 mg/kg vs 0.6 mg/kg MK-801. Conclusion： Antagonism of kappa opioid receptors attenuates MK-801-induced behavior, suggesting a potential involvement of the kappa opioid receptor in psychosis-like symptoms of schizophrenia. GNTI appears to be a useful pharmacological tool to explore the kappa opioid receptor function in vivo.</description><identifier>ISSN: 1671-4083</identifier><identifier>EISSN: 1745-7254</identifier><identifier>DOI: 10.1111/j.1745-7254.2006.00448.x</identifier><identifier>PMID: 17049114</identifier><language>eng</language><publisher>United States: Nature Publishing Group</publisher><subject>Animals ; Dizocilpine Maleate - antagonists & inhibitors ; Guanidines - pharmacology ; Locomotion - drug effects ; Male ; Mice ; Mice, Inbred BALB C ; Morphinans - pharmacology ; Receptors, Opioid, kappa - antagonists & inhibitors ; Schizophrenia - physiopathology ; Stereotyped Behavior - drug effects ; 病理机制 ; 精神分裂症 ; 阿片受体</subject><ispartof>Acta pharmacologica Sinica, 2006-11, Vol.27 (11), p.1401-1408</ispartof><rights>Copyright Nature Publishing Group Nov 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-5bc24ce6e61f32b555cffef7290bf37750d141df8528f1b443a25f1c14f8e003</citedby><cites>FETCH-LOGICAL-c442t-5bc24ce6e61f32b555cffef7290bf37750d141df8528f1b443a25f1c14f8e003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/95561A/95561A.jpg</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17049114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qi, Chun-ting</creatorcontrib><creatorcontrib>Zou, Hong</creatorcontrib><creatorcontrib>Zhang, Chen-hao</creatorcontrib><creatorcontrib>Xie, Qing-lian</creatorcontrib><creatorcontrib>Jin, Mei-lei</creatorcontrib><creatorcontrib>Yu, Lei</creatorcontrib><title>Effect of GNTI, a kappa opioid receptor antagonist, on MK-801-induced hyperlocomotion and stereotypy in mice</title><title>Acta pharmacologica Sinica</title><addtitle>Acta Pharmacologica Sinica</addtitle><description>Aim： To examine the effect of GNTI [5＇-guanidinyl-17-（cyclopropylmethyl）-6,7- dehydro-4,5ot-epoxy-3,14-dihydroxy-6,7-2＇,3＇-indolomorphinan], a selective antagonist for the kappa opioid receptor, in the MK-801 （dizocilpine maleate）-induced behavioral model of psychosis in schizophrenia as a way to explore the involvement of the kappa opioid receptor in modulating psychotic symptoms of schizophrenia. Methods： Two doses of MK-801 （0.3 mg/kg and 0.6 mg/kg） were administered by systemic injection in mice to induce psychosis-like behavior as a rodent schizophrenia model, preceded by an injection of different doses of GNTI. Both locomotion and stereotypy were measured as the behavioral endpoints for quantitative analysis. Results： GNTI inhibited MK-801-induced hypeflocomotion and stereotypy. In particular, GNTI showed differential modulation of stereotypy induced by 0.3 mg/kg vs 0.6 mg/kg MK-801. Conclusion： Antagonism of kappa opioid receptors attenuates MK-801-induced behavior, suggesting a potential involvement of the kappa opioid receptor in psychosis-like symptoms of schizophrenia. GNTI appears to be a useful pharmacological tool to explore the kappa opioid receptor function in vivo.</description><subject>Animals</subject><subject>Dizocilpine Maleate - antagonists & inhibitors</subject><subject>Guanidines - pharmacology</subject><subject>Locomotion - drug effects</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Morphinans - pharmacology</subject><subject>Receptors, Opioid, kappa - antagonists & inhibitors</subject><subject>Schizophrenia - physiopathology</subject><subject>Stereotyped Behavior - drug effects</subject><subject>病理机制</subject><subject>精神分裂症</subject><subject>阿片受体</subject><issn>1671-4083</issn><issn>1745-7254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkc1u3CAUha2qVZOmfYUKddFV7PJrmGUVpWnUtN3MHmEMEyY2EMBS5u2DO6NEKhuQ7nePDuc0DUCwQ_V823eIU9ZyzGiHIew7CCkV3dOb5vxl8La-e45aCgU5az7kvIeQYII275szxCHdIETPm-naWqMLCBbc_NneXgIFHlSMCoToghtBMtrEEhJQvqhd8C6XSxA8-P2rFRC1zo-LNiO4P0STpqDDHIqrY-VHkItJJpRDPADnwey0-di8s2rK5tPpvmi2P663Vz_bu783t1ff71pNKS4tGzSm2vSmR5bggTGmq0nL8QYOlnDO4IgoGq1gWFg0UEoUZhZpRK0w9ZMXzdejbEzhcTG5yNllbaZJeROWLHux4ZTTFfzyH7gPS_LVmsSIQNZDjiskjpBOIedkrIzJzSodJIJybUPu5Rq6XEOXaxvyXxvyqa5-Pukvw2zG18VT_BUAR8CrsiTzAqiYVyEk-KtHfR_87tH5nRyUfrBuMrK2CQkThDwDGKCbnw</recordid><startdate>20061101</startdate><enddate>20061101</enddate><creator>Qi, Chun-ting</creator><creator>Zou, Hong</creator><creator>Zhang, Chen-hao</creator><creator>Xie, Qing-lian</creator><creator>Jin, Mei-lei</creator><creator>Yu, Lei</creator><general>Nature Publishing Group</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20061101</creationdate><title>Effect of GNTI, a kappa opioid receptor antagonist, on MK-801-induced hyperlocomotion and stereotypy in mice</title><author>Qi, Chun-ting ; Zou, Hong ; Zhang, Chen-hao ; Xie, Qing-lian ; Jin, Mei-lei ; Yu, Lei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-5bc24ce6e61f32b555cffef7290bf37750d141df8528f1b443a25f1c14f8e003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Dizocilpine Maleate - antagonists & inhibitors</topic><topic>Guanidines - pharmacology</topic><topic>Locomotion - drug effects</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Morphinans - pharmacology</topic><topic>Receptors, Opioid, kappa - antagonists & inhibitors</topic><topic>Schizophrenia - physiopathology</topic><topic>Stereotyped Behavior - drug effects</topic><topic>病理机制</topic><topic>精神分裂症</topic><topic>阿片受体</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qi, Chun-ting</creatorcontrib><creatorcontrib>Zou, Hong</creatorcontrib><creatorcontrib>Zhang, Chen-hao</creatorcontrib><creatorcontrib>Xie, Qing-lian</creatorcontrib><creatorcontrib>Jin, Mei-lei</creatorcontrib><creatorcontrib>Yu, Lei</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Acta pharmacologica Sinica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qi, Chun-ting</au><au>Zou, Hong</au><au>Zhang, Chen-hao</au><au>Xie, Qing-lian</au><au>Jin, Mei-lei</au><au>Yu, Lei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of GNTI, a kappa opioid receptor antagonist, on MK-801-induced hyperlocomotion and stereotypy in mice</atitle><jtitle>Acta pharmacologica Sinica</jtitle><addtitle>Acta Pharmacologica Sinica</addtitle><date>2006-11-01</date><risdate>2006</risdate><volume>27</volume><issue>11</issue><spage>1401</spage><epage>1408</epage><pages>1401-1408</pages><issn>1671-4083</issn><eissn>1745-7254</eissn><abstract>Aim： To examine the effect of GNTI [5＇-guanidinyl-17-（cyclopropylmethyl）-6,7- dehydro-4,5ot-epoxy-3,14-dihydroxy-6,7-2＇,3＇-indolomorphinan], a selective antagonist for the kappa opioid receptor, in the MK-801 （dizocilpine maleate）-induced behavioral model of psychosis in schizophrenia as a way to explore the involvement of the kappa opioid receptor in modulating psychotic symptoms of schizophrenia. Methods： Two doses of MK-801 （0.3 mg/kg and 0.6 mg/kg） were administered by systemic injection in mice to induce psychosis-like behavior as a rodent schizophrenia model, preceded by an injection of different doses of GNTI. Both locomotion and stereotypy were measured as the behavioral endpoints for quantitative analysis. Results： GNTI inhibited MK-801-induced hypeflocomotion and stereotypy. In particular, GNTI showed differential modulation of stereotypy induced by 0.3 mg/kg vs 0.6 mg/kg MK-801. Conclusion： Antagonism of kappa opioid receptors attenuates MK-801-induced behavior, suggesting a potential involvement of the kappa opioid receptor in psychosis-like symptoms of schizophrenia. GNTI appears to be a useful pharmacological tool to explore the kappa opioid receptor function in vivo.</abstract><cop>United States</cop><pub>Nature Publishing Group</pub><pmid>17049114</pmid><doi>10.1111/j.1745-7254.2006.00448.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Dizocilpine Maleate - antagonists & inhibitors Guanidines - pharmacology Locomotion - drug effects Male Mice Mice, Inbred BALB C Morphinans - pharmacology Receptors, Opioid, kappa - antagonists & inhibitors Schizophrenia - physiopathology Stereotyped Behavior - drug effects 病理机制 精神分裂症 阿片受体 |
| title | Effect of GNTI, a kappa opioid receptor antagonist, on MK-801-induced hyperlocomotion and stereotypy in mice |
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