Design and synthesis of pyrimido[4,5- b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors

A group of 2-substituted pyrimido[4,5- b][1,4]benzothiazines were designed, synthesized, and evaluated as potential inhibitors of 15-lipoxygenase (15-LO). Compounds 4d and 4e showed the best IC 50 of 15-LO inhibition (IC 50 = 18 and 34 μM, respectively). All compounds were docked into 15-LO. As a re...

Ausführliche Beschreibung