A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity

Bioassay-guided fractionation of a cytotoxic EtOAc extract of the plant-associated fungal strain, Chaetomium globosum, afforded a new cytotoxic and cell cycle inhibitory xanthenone, globosuxanthone A, and several other structurally related inactive metabolites. Bioassay-guided fractionation of a cyt...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2006-12, Vol.14 (23), p.7917-7923
Hauptverfasser:	Wijeratne, E.M. Kithsiri, Turbyville, Thomas J., Fritz, Anne, Whitesell, Luke, Gunatilaka, A.A. Leslie
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthraquinones Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Apoptosis - drug effects Biological and medical sciences Cell Cycle - drug effects Cell Line, Tumor Cell-cycle disruptor Chaetomium - chemistry Chaetomium globosum Cytotoxicity Drug Screening Assays, Antitumor General pharmacology Globosuxanthones A–D Humans Medical sciences Molecular Structure Opuntia leptocaulis Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant-associated fungus Stereoisomerism Xanthenes - isolation & purification Xanthenes - pharmacology
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