Blockade of the renin-angiotensin system improves insulin sensitivity in thermal injury

Insulin resistance after burn is associated with alterations in postreceptor insulin signaling and abnormal glucose homeostasis. The renin-angiotensin system (RAS) exerts a largely inhibitory role on insulin action and is activated after burn injury. We hypothesized that upregulation of RAS is invol...

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Veröffentlicht in:	Shock (Augusta, Ga.) Ga.), 2006-11, Vol.26 (5), p.485-488
Hauptverfasser:	KASPER, Sherry O, CASTLE, Scott M, DALEY, Brian J, ENDERSON, Blaine L, KARLSTAD, Michael D
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Angiotensin II - blood Angiotensin II - drug effects Animals Area Under Curve Biological and medical sciences Blood Glucose - analysis Burns - complications Burns - drug therapy Burns - metabolism Digestive system Injuries of the abdomen. Foreign bodies of the digestive system Insulin - blood Insulin Resistance Intensive care medicine Investigative techniques, diagnostic techniques (general aspects) Losartan - pharmacology Male Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Rats Rats, Sprague-Dawley Renin-Angiotensin System - drug effects Renin-Angiotensin System - physiology Traumas. Diseases due to physical agents
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