Indole, a core nucleus for potent inhibitors of tubulin polymerization

Microtubules are the basic components of cell structure, which take part in a wide number of pivotal cellular functions. Drugs that are able to modulate the microtubule assembly either by inhibition of tubulin polymerization or by blocking microtubule disassembly are of great interest in anti‐cancer...

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Veröffentlicht in:	Medicinal research reviews 2007-03, Vol.27 (2), p.209-238
Hauptverfasser:	Brancale, Andrea, Silvestri, Romano
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-mitotic agents anti-tumor drugs Antimitotic Agents - chemistry Antimitotic Agents - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biochemistry - methods Drug Design Humans indoles Indoles - chemistry Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - pharmacology Structure-Activity Relationship tubulin Tubulin - drug effects Tubulin - metabolism Tubulin Modulators
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