Effect of calcium, vitamins K1 and D3 on bone in galactosemia
Classical galactosemia is an inherited disorder of galactose metabolism. Recently, diminished bone mineral content (BMC) in children and adolescents has been found. The aim of this study was to evaluate the effect of calcium, vitamins K1 and D3 supplementation on bone in children with galactosemia....
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| Veröffentlicht in: | Bone (New York, N.Y.) N.Y.), 2006-11, Vol.39 (5), p.1123-1129 |
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| creator | Panis, Bianca Vermeer, Cees van Kroonenburgh, Marinus J.P.G. Nieman, Fred H.M. Menheere, Paul P.C.A. Spaapen, Leo J. Rubio-Gozalbo, M. Estela |
| description | Classical galactosemia is an inherited disorder of galactose metabolism. Recently, diminished bone mineral content (BMC) in children and adolescents has been found. The aim of this study was to evaluate the effect of calcium, vitamins K1 and D3 supplementation on bone in children with galactosemia. A 2-year randomized, double-blind, placebo-controlled clinical trial was undertaken in which 40 children with classical galactosemia (13 males and 27 females, aged 3–17 years) were included to receive daily either 750 mg calcium, 1.0 mg vitamin K1 and 10.0 μg vitamin D3 or placebo. BMC of femoral neck, lumbar spine and total body and body composition data were determined by dual energy X-ray absorptiometry (DXA) at baseline and after 1 and 2 years. Diet was assessed using a food frequency questionnaire and a 3-day food diary. Biochemical measurements were determined at baseline and after 1 and 2 years. In the children receiving treatment, carboxylated osteocalcin (cOC) concentration significantly increased (P |
| doi_str_mv | 10.1016/j.bone.2006.05.002 |
| format | Article |
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Estela</creator><creatorcontrib>Panis, Bianca ; Vermeer, Cees ; van Kroonenburgh, Marinus J.P.G. ; Nieman, Fred H.M. ; Menheere, Paul P.C.A. ; Spaapen, Leo J. ; Rubio-Gozalbo, M. Estela</creatorcontrib><description>Classical galactosemia is an inherited disorder of galactose metabolism. Recently, diminished bone mineral content (BMC) in children and adolescents has been found. The aim of this study was to evaluate the effect of calcium, vitamins K1 and D3 supplementation on bone in children with galactosemia. A 2-year randomized, double-blind, placebo-controlled clinical trial was undertaken in which 40 children with classical galactosemia (13 males and 27 females, aged 3–17 years) were included to receive daily either 750 mg calcium, 1.0 mg vitamin K1 and 10.0 μg vitamin D3 or placebo. BMC of femoral neck, lumbar spine and total body and body composition data were determined by dual energy X-ray absorptiometry (DXA) at baseline and after 1 and 2 years. Diet was assessed using a food frequency questionnaire and a 3-day food diary. Biochemical measurements were determined at baseline and after 1 and 2 years. In the children receiving treatment, carboxylated osteocalcin (cOC) concentration significantly increased (P < 0.001) and undercarboxylated osteocalcin (ucOC) concentration significantly decreased (P = 0.001) when compared to the children receiving placebo. Furthermore, there was a statistically significant increase in BMC of lumbar spine (P = 0.001), lean tissue mass (LTM: P = 0.016) and fat mass (FM: P = 0.014) in the treatment group when compared to the placebo group. The significant increase in cOC and decrease in ucOC concentration in the treatment group were present in prepubertal (P < 0.001 and P = 0.006 respectively) and pubertal children (P = 0.004 and P = 0.042 respectively). The significant increase in BMC of lumbar spine in the treatment group was present only in the prepubertal children (P = 0.015). Supplementation of calcium, vitamins K1 and D3 given in this dose (750 mg, 1.0 mg and 10.0 μg respectively) is likely to have a role in the treatment of BMC abnormalities in galactosemia.</description><identifier>ISSN: 8756-3282</identifier><identifier>EISSN: 1873-2763</identifier><identifier>DOI: 10.1016/j.bone.2006.05.002</identifier><identifier>PMID: 16782422</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Absorptiometry, Photon ; Adolescent ; Biological and medical sciences ; Body Composition - drug effects ; Bone and Bones - drug effects ; Bone and Bones - metabolism ; Bone Density - drug effects ; Bone mineral content (BMC) ; Calcium ; Calcium - administration & dosage ; Calcium - therapeutic use ; Carbohydrates (enzymatic deficiencies). Glycogenosis ; Child ; Child, Preschool ; Dietary Supplements ; Dose-Response Relationship, Drug ; Double-Blind Method ; Errors of metabolism ; Female ; Galactosemia ; Galactosemias - drug therapy ; Galactosemias - metabolism ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Metabolic diseases ; Osteoarticular system. Muscles ; Osteocalcin - chemistry ; Osteocalcin - metabolism ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Treatment Outcome ; Vitamin D - administration & dosage ; Vitamin D - therapeutic use ; Vitamin D3 ; Vitamin K 1 - administration & dosage ; Vitamin K 1 - therapeutic use ; Vitamin K1 ; Vitamins - administration & dosage ; Vitamins - therapeutic use</subject><ispartof>Bone (New York, N.Y.), 2006-11, Vol.39 (5), p.1123-1129</ispartof><rights>2006 Elsevier Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bone.2006.05.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18237147$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16782422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Panis, Bianca</creatorcontrib><creatorcontrib>Vermeer, Cees</creatorcontrib><creatorcontrib>van Kroonenburgh, Marinus J.P.G.</creatorcontrib><creatorcontrib>Nieman, Fred H.M.</creatorcontrib><creatorcontrib>Menheere, Paul P.C.A.</creatorcontrib><creatorcontrib>Spaapen, Leo J.</creatorcontrib><creatorcontrib>Rubio-Gozalbo, M. Estela</creatorcontrib><title>Effect of calcium, vitamins K1 and D3 on bone in galactosemia</title><title>Bone (New York, N.Y.)</title><addtitle>Bone</addtitle><description>Classical galactosemia is an inherited disorder of galactose metabolism. Recently, diminished bone mineral content (BMC) in children and adolescents has been found. The aim of this study was to evaluate the effect of calcium, vitamins K1 and D3 supplementation on bone in children with galactosemia. A 2-year randomized, double-blind, placebo-controlled clinical trial was undertaken in which 40 children with classical galactosemia (13 males and 27 females, aged 3–17 years) were included to receive daily either 750 mg calcium, 1.0 mg vitamin K1 and 10.0 μg vitamin D3 or placebo. BMC of femoral neck, lumbar spine and total body and body composition data were determined by dual energy X-ray absorptiometry (DXA) at baseline and after 1 and 2 years. Diet was assessed using a food frequency questionnaire and a 3-day food diary. Biochemical measurements were determined at baseline and after 1 and 2 years. In the children receiving treatment, carboxylated osteocalcin (cOC) concentration significantly increased (P < 0.001) and undercarboxylated osteocalcin (ucOC) concentration significantly decreased (P = 0.001) when compared to the children receiving placebo. Furthermore, there was a statistically significant increase in BMC of lumbar spine (P = 0.001), lean tissue mass (LTM: P = 0.016) and fat mass (FM: P = 0.014) in the treatment group when compared to the placebo group. The significant increase in cOC and decrease in ucOC concentration in the treatment group were present in prepubertal (P < 0.001 and P = 0.006 respectively) and pubertal children (P = 0.004 and P = 0.042 respectively). The significant increase in BMC of lumbar spine in the treatment group was present only in the prepubertal children (P = 0.015). Supplementation of calcium, vitamins K1 and D3 given in this dose (750 mg, 1.0 mg and 10.0 μg respectively) is likely to have a role in the treatment of BMC abnormalities in galactosemia.</description><subject>Absorptiometry, Photon</subject><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Body Composition - drug effects</subject><subject>Bone and Bones - drug effects</subject><subject>Bone and Bones - metabolism</subject><subject>Bone Density - drug effects</subject><subject>Bone mineral content (BMC)</subject><subject>Calcium</subject><subject>Calcium - administration & dosage</subject><subject>Calcium - therapeutic use</subject><subject>Carbohydrates (enzymatic deficiencies). Glycogenosis</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dietary Supplements</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Errors of metabolism</subject><subject>Female</subject><subject>Galactosemia</subject><subject>Galactosemias - drug therapy</subject><subject>Galactosemias - metabolism</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Osteoarticular system. Muscles</subject><subject>Osteocalcin - chemistry</subject><subject>Osteocalcin - metabolism</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Treatment Outcome</subject><subject>Vitamin D - administration & dosage</subject><subject>Vitamin D - therapeutic use</subject><subject>Vitamin D3</subject><subject>Vitamin K 1 - administration & dosage</subject><subject>Vitamin K 1 - therapeutic use</subject><subject>Vitamin K1</subject><subject>Vitamins - administration & dosage</subject><subject>Vitamins - therapeutic use</subject><issn>8756-3282</issn><issn>1873-2763</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUtPwzAQhC0EouXxBzggX-BEwvpRO5HggEp5iEpc4Gy5mw1ylQfEKRL_nkQt4jSXTzs7M4ydCUgFCHO9TldtQ6kEMCnMUgC5x6YisyqR1qh9Ns3szCRKZnLCjmJcA4DKrThkE2FsJrWUU3a7KEvCnrclR19h2NRX_Dv0vg5N5C-C-6bg94q3DR-9eGj4h6889m2kOvgTdlD6KtLpTo_Z-8Pibf6ULF8fn-d3y4Qk2D5Rg2jKUBlCq4UcfsTCIGoQiAoKIWUGmINEmZemNEAExkhti1xrTbk6Zpfbu59d-7Wh2Ls6RKSq8g21m-hMlhur9Qie78DNqqbCfXah9t2P-ws8ABc7wMchcNn5BkP85zKprNB24G62HA2xvgN1LmKgBqkI3dCXK9rgBLhxB7d2Yzdu3MHBzA07qF93QXcD</recordid><startdate>200611</startdate><enddate>200611</enddate><creator>Panis, Bianca</creator><creator>Vermeer, Cees</creator><creator>van Kroonenburgh, Marinus J.P.G.</creator><creator>Nieman, Fred H.M.</creator><creator>Menheere, Paul P.C.A.</creator><creator>Spaapen, Leo J.</creator><creator>Rubio-Gozalbo, M. Estela</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200611</creationdate><title>Effect of calcium, vitamins K1 and D3 on bone in galactosemia</title><author>Panis, Bianca ; Vermeer, Cees ; van Kroonenburgh, Marinus J.P.G. ; Nieman, Fred H.M. ; Menheere, Paul P.C.A. ; Spaapen, Leo J. ; Rubio-Gozalbo, M. Estela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e207t-3e204e8c36ec7412187cd6cc401cc30d12280c902c29f6f60ee066247d9444e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Absorptiometry, Photon</topic><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Body Composition - drug effects</topic><topic>Bone and Bones - drug effects</topic><topic>Bone and Bones - metabolism</topic><topic>Bone Density - drug effects</topic><topic>Bone mineral content (BMC)</topic><topic>Calcium</topic><topic>Calcium - administration & dosage</topic><topic>Calcium - therapeutic use</topic><topic>Carbohydrates (enzymatic deficiencies). Glycogenosis</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dietary Supplements</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Errors of metabolism</topic><topic>Female</topic><topic>Galactosemia</topic><topic>Galactosemias - drug therapy</topic><topic>Galactosemias - metabolism</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Osteoarticular system. Muscles</topic><topic>Osteocalcin - chemistry</topic><topic>Osteocalcin - metabolism</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Treatment Outcome</topic><topic>Vitamin D - administration & dosage</topic><topic>Vitamin D - therapeutic use</topic><topic>Vitamin D3</topic><topic>Vitamin K 1 - administration & dosage</topic><topic>Vitamin K 1 - therapeutic use</topic><topic>Vitamin K1</topic><topic>Vitamins - administration & dosage</topic><topic>Vitamins - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Panis, Bianca</creatorcontrib><creatorcontrib>Vermeer, Cees</creatorcontrib><creatorcontrib>van Kroonenburgh, Marinus J.P.G.</creatorcontrib><creatorcontrib>Nieman, Fred H.M.</creatorcontrib><creatorcontrib>Menheere, Paul P.C.A.</creatorcontrib><creatorcontrib>Spaapen, Leo J.</creatorcontrib><creatorcontrib>Rubio-Gozalbo, M. 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Estela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of calcium, vitamins K1 and D3 on bone in galactosemia</atitle><jtitle>Bone (New York, N.Y.)</jtitle><addtitle>Bone</addtitle><date>2006-11</date><risdate>2006</risdate><volume>39</volume><issue>5</issue><spage>1123</spage><epage>1129</epage><pages>1123-1129</pages><issn>8756-3282</issn><eissn>1873-2763</eissn><abstract>Classical galactosemia is an inherited disorder of galactose metabolism. Recently, diminished bone mineral content (BMC) in children and adolescents has been found. The aim of this study was to evaluate the effect of calcium, vitamins K1 and D3 supplementation on bone in children with galactosemia. A 2-year randomized, double-blind, placebo-controlled clinical trial was undertaken in which 40 children with classical galactosemia (13 males and 27 females, aged 3–17 years) were included to receive daily either 750 mg calcium, 1.0 mg vitamin K1 and 10.0 μg vitamin D3 or placebo. BMC of femoral neck, lumbar spine and total body and body composition data were determined by dual energy X-ray absorptiometry (DXA) at baseline and after 1 and 2 years. Diet was assessed using a food frequency questionnaire and a 3-day food diary. Biochemical measurements were determined at baseline and after 1 and 2 years. In the children receiving treatment, carboxylated osteocalcin (cOC) concentration significantly increased (P < 0.001) and undercarboxylated osteocalcin (ucOC) concentration significantly decreased (P = 0.001) when compared to the children receiving placebo. Furthermore, there was a statistically significant increase in BMC of lumbar spine (P = 0.001), lean tissue mass (LTM: P = 0.016) and fat mass (FM: P = 0.014) in the treatment group when compared to the placebo group. The significant increase in cOC and decrease in ucOC concentration in the treatment group were present in prepubertal (P < 0.001 and P = 0.006 respectively) and pubertal children (P = 0.004 and P = 0.042 respectively). The significant increase in BMC of lumbar spine in the treatment group was present only in the prepubertal children (P = 0.015). Supplementation of calcium, vitamins K1 and D3 given in this dose (750 mg, 1.0 mg and 10.0 μg respectively) is likely to have a role in the treatment of BMC abnormalities in galactosemia.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16782422</pmid><doi>10.1016/j.bone.2006.05.002</doi><tpages>7</tpages></addata></record> |
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| subjects | Absorptiometry, Photon Adolescent Biological and medical sciences Body Composition - drug effects Bone and Bones - drug effects Bone and Bones - metabolism Bone Density - drug effects Bone mineral content (BMC) Calcium Calcium - administration & dosage Calcium - therapeutic use Carbohydrates (enzymatic deficiencies). Glycogenosis Child Child, Preschool Dietary Supplements Dose-Response Relationship, Drug Double-Blind Method Errors of metabolism Female Galactosemia Galactosemias - drug therapy Galactosemias - metabolism Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Metabolic diseases Osteoarticular system. Muscles Osteocalcin - chemistry Osteocalcin - metabolism Radiodiagnosis. Nmr imagery. Nmr spectrometry Treatment Outcome Vitamin D - administration & dosage Vitamin D - therapeutic use Vitamin D3 Vitamin K 1 - administration & dosage Vitamin K 1 - therapeutic use Vitamin K1 Vitamins - administration & dosage Vitamins - therapeutic use |
| title | Effect of calcium, vitamins K1 and D3 on bone in galactosemia |
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