Clinical efficacy of a single afternoon dose of effervescent levodopa-carbidopa preparation (CHF 1512) in fluctuating Parkinson disease

A possible cause of motor fluctuations in patients with Parkinson disease is the erratic drug absorption. In a randomized double-blind double-dummy study of melevodopa (levodopa methyl ester), a highly soluble levodopa pro-drug plus carbidopa (CHF 1512) was compared to a standard formulation of levo...

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Veröffentlicht in:	Clinical neuropharmacology 2007-01, Vol.30 (1), p.18-24
Hauptverfasser:	Stocchi, Fabrizio, Fabbri, Laura, Vecsei, Laszlo, Krygowska-Wajs, Anna, Monici Preti, Piero Alessandro, Ruggieri, Stefano A
Format:	Artikel
Sprache:	eng
Schlagworte:	Activities of Daily Living Aged Antiparkinson Agents Carbidopa - therapeutic use Double-Blind Method Drug Administration Schedule Drug Combinations Female Humans Levodopa - analogs & derivatives Levodopa - therapeutic use Male Motor Activity - drug effects Motor Skills Disorders - etiology Motor Skills Disorders - prevention & control Nausea - chemically induced Parkinson Disease - complications Parkinson Disease - drug therapy
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