The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in mice

Receptors of the P2X7 type have been demonstrated in granulocytes, monocytes/macrophages, B and T lymphocytes, and have been involved in several cellular mechanisms including those related to inflammation and immunological response. This study attempted to investigate the role of these receptors on...

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Veröffentlicht in:	Kidney international 2006-11, Vol.70 (9), p.1599-1606
Hauptverfasser:	Gonçalves, R.G., Gabrich, L., Rosário, A., Takiya, C.M., Ferreira, M. L.L., Chiarini, L.B., Persechini, P.M., Coutinho-Silva, R., Leite, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Actins - metabolism Animals Antigens, Differentiation - genetics Antigens, Differentiation - metabolism apoptosis Apoptosis - physiology Atrophy - metabolism Atrophy - pathology Atrophy - physiopathology Biological and medical sciences Collagen - genetics Collagen - metabolism Fibroblasts - metabolism Fibroblasts - pathology fibrosis Fibrosis - metabolism Fibrosis - pathology Fibrosis - physiopathology Gene Expression Regulation - physiology Inflammation - metabolism Inflammation - pathology Inflammation - physiopathology Kidney Tubules - metabolism Kidney Tubules - pathology Kidney Tubules - physiopathology Macrophages - metabolism Macrophages - pathology Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Nephrology. Urinary tract diseases P2X7 receptors Receptors, Purinergic P2 - genetics Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2 - physiology Receptors, Purinergic P2X7 renal inflammation TGF-β Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism unilateral ureteral obstruction Ureteral Obstruction - metabolism Ureteral Obstruction - pathology Ureteral Obstruction - physiopathology Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland
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