Evidence for unique association signals in SLE at the CD28–CTLA4–ICOS locus in a family-based study

CD28, CTLA4 (cytotoxic T lymphocyte-associated protein 4) and ICOS (inducible T cell co-stimulator) are good candidate genes for systemic lupus erythematosus (SLE) because of their role in regulating T cell activation. CTLA4 inhibits CD28-mediated T cell activation. CTLA4 is expressed on CD4+ and CD...

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Veröffentlicht in:	Human molecular genetics 2006-11, Vol.15 (21), p.3195-3205
Hauptverfasser:	Graham, D.S. Cunninghame, Wong, A.K., McHugh, N.J., Whittaker, J.C., Vyse, Timothy J.
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Flanking Region Antigens, CD - genetics Antigens, Differentiation - genetics Antigens, Differentiation, T-Lymphocyte - genetics Base Sequence Biological and medical sciences CD28 Antigens - genetics Chromosome Mapping CTLA-4 Antigen Family Female Fundamental and applied biological sciences. Psychology Gene Frequency Genetic Markers Genetics of eukaryotes. Biological and molecular evolution Haplotypes Humans Inducible T-Cell Co-Stimulator Protein Lupus Erythematosus, Systemic - genetics Male Molecular and cellular biology Molecular Sequence Data Multigene Family Polymorphism, Single Nucleotide
Online-Zugang:	Volltext
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