Effect of Mitomycin C on the Size of Antrostomy after Endoscopic Sinus Surgery
Objectives: Mitomycin C (MMC) is an antibiotic-antineoplastic agent that decreases fibroblast proliferation and scar formation. We aimed to evaluate the effect of MMC on the size of antrostomy and the mucociliary clearance rate. Methods: We selected 20 patients with chronic sinusitis on both sides....
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| Veröffentlicht in: | Annals of otology, rhinology & laryngology rhinology & laryngology, 2006-09, Vol.115 (9), p.673-678 |
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| container_title | Annals of otology, rhinology & laryngology |
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| creator | Kim, Seon-Tae Gang, Il-Gyu Cha, Heung-Eog Ha, Jong-Su Chung, Yoo-Sam |
| description | Objectives:
Mitomycin C (MMC) is an antibiotic-antineoplastic agent that decreases fibroblast proliferation and scar formation. We aimed to evaluate the effect of MMC on the size of antrostomy and the mucociliary clearance rate.
Methods:
We selected 20 patients with chronic sinusitis on both sides. After middle meatal antrostomy, we selected one side, and a piece of Merocel soaked with 1.5 mL of MMC (0.4 mg/mL) was applied for 5 minutes. On the other side, normal saline solution was applied for a control. The size of the antrostomy was measured serially after surgery with a ruler. Mucociliary clearance was assessed by the saccharin test.
Results:
The effect of MMC in maintaining the size of the antrostomy was only significant during the first month. The relative size (the ratio of the remaining antrostomy area compared to the area in the immediate postoperative period) in the first month was significantly greater on the MMC-treated side than on the control side. The results of the saccharin test were not different between the two sides.
Conclusions:
Topical MMC application may have a short-term effect in maintaining the patency of the antrostomy site. However, it does not seem to improve the relative size over an extended period of time. |
| doi_str_mv | 10.1177/000348940611500904 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68965143</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_000348940611500904</sage_id><sourcerecordid>1140491271</sourcerecordid><originalsourceid>FETCH-LOGICAL-c398t-988dcf366c3433165394724199e08499280d8e9fc130a21419f3c86b58115c373</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMotlb_gAcJgt7W5mt3k2Mp9QOqHqrgbUmzSd2yTWqye6i_3ixdKCh4Gob3mXdmXgAuMbrDOM_HCCHKuGAowzhFSCB2BIZYMJqkOfk4BsMOSDpiAM5CWMeWpYicggHOEWMp5UPwMjNGqwY6A5-rxm12qrJwCp2FzaeGi-pbd9LENt6FTobSNNrDmS1dUG5bqcjYNsBF61fa787BiZF10Bd9HYH3-9nb9DGZvz48TSfzRFHBm0RwXipDs0xRRinOUipYThgWQiPOhCAclVwLozBFkuAoGKp4tkx5_FTRnI7A7d53691Xq0NTbKqgdF1Lq10bioyLLMXRewSuf4Fr13obbysIzrnANO_cyB5S8cvgtSm2vtpIvyswKrqoi79Rx6Gr3rldbnR5GOmzjcBND8igZG28tKoKB47H3TQlkRvvuSBX-nDeP6t_AMp7j8M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>217891377</pqid></control><display><type>article</type><title>Effect of Mitomycin C on the Size of Antrostomy after Endoscopic Sinus Surgery</title><source>SAGE Complete A-Z List</source><source>MEDLINE</source><creator>Kim, Seon-Tae ; Gang, Il-Gyu ; Cha, Heung-Eog ; Ha, Jong-Su ; Chung, Yoo-Sam</creator><creatorcontrib>Kim, Seon-Tae ; Gang, Il-Gyu ; Cha, Heung-Eog ; Ha, Jong-Su ; Chung, Yoo-Sam</creatorcontrib><description>Objectives:
Mitomycin C (MMC) is an antibiotic-antineoplastic agent that decreases fibroblast proliferation and scar formation. We aimed to evaluate the effect of MMC on the size of antrostomy and the mucociliary clearance rate.
Methods:
We selected 20 patients with chronic sinusitis on both sides. After middle meatal antrostomy, we selected one side, and a piece of Merocel soaked with 1.5 mL of MMC (0.4 mg/mL) was applied for 5 minutes. On the other side, normal saline solution was applied for a control. The size of the antrostomy was measured serially after surgery with a ruler. Mucociliary clearance was assessed by the saccharin test.
Results:
The effect of MMC in maintaining the size of the antrostomy was only significant during the first month. The relative size (the ratio of the remaining antrostomy area compared to the area in the immediate postoperative period) in the first month was significantly greater on the MMC-treated side than on the control side. The results of the saccharin test were not different between the two sides.
Conclusions:
Topical MMC application may have a short-term effect in maintaining the patency of the antrostomy site. However, it does not seem to improve the relative size over an extended period of time.</description><identifier>ISSN: 0003-4894</identifier><identifier>EISSN: 1943-572X</identifier><identifier>DOI: 10.1177/000348940611500904</identifier><identifier>PMID: 17044538</identifier><identifier>CODEN: AORHA2</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Administration, Topical ; Adolescent ; Adult ; Aged ; Antibiotics, Antineoplastic - therapeutic use ; Biological and medical sciences ; Chronic Disease ; Cicatrix - prevention & control ; Constriction, Pathologic - prevention & control ; Endoscopy ; Female ; Humans ; Male ; Maxillary Sinus - pathology ; Maxillary Sinus - surgery ; Maxillary Sinusitis - surgery ; Medical sciences ; Middle Aged ; Mitomycin - therapeutic use ; Otorhinolaryngology. Stomatology ; Postoperative Complications - prevention & control</subject><ispartof>Annals of otology, rhinology & laryngology, 2006-09, Vol.115 (9), p.673-678</ispartof><rights>2006 SAGE Publications</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Annals Publishing Company Sep 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-988dcf366c3433165394724199e08499280d8e9fc130a21419f3c86b58115c373</citedby><cites>FETCH-LOGICAL-c398t-988dcf366c3433165394724199e08499280d8e9fc130a21419f3c86b58115c373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/000348940611500904$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/000348940611500904$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18137352$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17044538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Seon-Tae</creatorcontrib><creatorcontrib>Gang, Il-Gyu</creatorcontrib><creatorcontrib>Cha, Heung-Eog</creatorcontrib><creatorcontrib>Ha, Jong-Su</creatorcontrib><creatorcontrib>Chung, Yoo-Sam</creatorcontrib><title>Effect of Mitomycin C on the Size of Antrostomy after Endoscopic Sinus Surgery</title><title>Annals of otology, rhinology & laryngology</title><addtitle>Ann Otol Rhinol Laryngol</addtitle><description>Objectives:
Mitomycin C (MMC) is an antibiotic-antineoplastic agent that decreases fibroblast proliferation and scar formation. We aimed to evaluate the effect of MMC on the size of antrostomy and the mucociliary clearance rate.
Methods:
We selected 20 patients with chronic sinusitis on both sides. After middle meatal antrostomy, we selected one side, and a piece of Merocel soaked with 1.5 mL of MMC (0.4 mg/mL) was applied for 5 minutes. On the other side, normal saline solution was applied for a control. The size of the antrostomy was measured serially after surgery with a ruler. Mucociliary clearance was assessed by the saccharin test.
Results:
The effect of MMC in maintaining the size of the antrostomy was only significant during the first month. The relative size (the ratio of the remaining antrostomy area compared to the area in the immediate postoperative period) in the first month was significantly greater on the MMC-treated side than on the control side. The results of the saccharin test were not different between the two sides.
Conclusions:
Topical MMC application may have a short-term effect in maintaining the patency of the antrostomy site. However, it does not seem to improve the relative size over an extended period of time.</description><subject>Administration, Topical</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibiotics, Antineoplastic - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Cicatrix - prevention & control</subject><subject>Constriction, Pathologic - prevention & control</subject><subject>Endoscopy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Maxillary Sinus - pathology</subject><subject>Maxillary Sinus - surgery</subject><subject>Maxillary Sinusitis - surgery</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mitomycin - therapeutic use</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Postoperative Complications - prevention & control</subject><issn>0003-4894</issn><issn>1943-572X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kE1LAzEQhoMotlb_gAcJgt7W5mt3k2Mp9QOqHqrgbUmzSd2yTWqye6i_3ixdKCh4Gob3mXdmXgAuMbrDOM_HCCHKuGAowzhFSCB2BIZYMJqkOfk4BsMOSDpiAM5CWMeWpYicggHOEWMp5UPwMjNGqwY6A5-rxm12qrJwCp2FzaeGi-pbd9LENt6FTobSNNrDmS1dUG5bqcjYNsBF61fa787BiZF10Bd9HYH3-9nb9DGZvz48TSfzRFHBm0RwXipDs0xRRinOUipYThgWQiPOhCAclVwLozBFkuAoGKp4tkx5_FTRnI7A7d53691Xq0NTbKqgdF1Lq10bioyLLMXRewSuf4Fr13obbysIzrnANO_cyB5S8cvgtSm2vtpIvyswKrqoi79Rx6Gr3rldbnR5GOmzjcBND8igZG28tKoKB47H3TQlkRvvuSBX-nDeP6t_AMp7j8M</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Kim, Seon-Tae</creator><creator>Gang, Il-Gyu</creator><creator>Cha, Heung-Eog</creator><creator>Ha, Jong-Su</creator><creator>Chung, Yoo-Sam</creator><general>SAGE Publications</general><general>Annals Publishing Compagny</general><general>SAGE PUBLICATIONS, INC</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20060901</creationdate><title>Effect of Mitomycin C on the Size of Antrostomy after Endoscopic Sinus Surgery</title><author>Kim, Seon-Tae ; Gang, Il-Gyu ; Cha, Heung-Eog ; Ha, Jong-Su ; Chung, Yoo-Sam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-988dcf366c3433165394724199e08499280d8e9fc130a21419f3c86b58115c373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Administration, Topical</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antibiotics, Antineoplastic - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Cicatrix - prevention & control</topic><topic>Constriction, Pathologic - prevention & control</topic><topic>Endoscopy</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Maxillary Sinus - pathology</topic><topic>Maxillary Sinus - surgery</topic><topic>Maxillary Sinusitis - surgery</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mitomycin - therapeutic use</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Postoperative Complications - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Seon-Tae</creatorcontrib><creatorcontrib>Gang, Il-Gyu</creatorcontrib><creatorcontrib>Cha, Heung-Eog</creatorcontrib><creatorcontrib>Ha, Jong-Su</creatorcontrib><creatorcontrib>Chung, Yoo-Sam</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Annals of otology, rhinology & laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Seon-Tae</au><au>Gang, Il-Gyu</au><au>Cha, Heung-Eog</au><au>Ha, Jong-Su</au><au>Chung, Yoo-Sam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Mitomycin C on the Size of Antrostomy after Endoscopic Sinus Surgery</atitle><jtitle>Annals of otology, rhinology & laryngology</jtitle><addtitle>Ann Otol Rhinol Laryngol</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>115</volume><issue>9</issue><spage>673</spage><epage>678</epage><pages>673-678</pages><issn>0003-4894</issn><eissn>1943-572X</eissn><coden>AORHA2</coden><abstract>Objectives:
Mitomycin C (MMC) is an antibiotic-antineoplastic agent that decreases fibroblast proliferation and scar formation. We aimed to evaluate the effect of MMC on the size of antrostomy and the mucociliary clearance rate.
Methods:
We selected 20 patients with chronic sinusitis on both sides. After middle meatal antrostomy, we selected one side, and a piece of Merocel soaked with 1.5 mL of MMC (0.4 mg/mL) was applied for 5 minutes. On the other side, normal saline solution was applied for a control. The size of the antrostomy was measured serially after surgery with a ruler. Mucociliary clearance was assessed by the saccharin test.
Results:
The effect of MMC in maintaining the size of the antrostomy was only significant during the first month. The relative size (the ratio of the remaining antrostomy area compared to the area in the immediate postoperative period) in the first month was significantly greater on the MMC-treated side than on the control side. The results of the saccharin test were not different between the two sides.
Conclusions:
Topical MMC application may have a short-term effect in maintaining the patency of the antrostomy site. However, it does not seem to improve the relative size over an extended period of time.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>17044538</pmid><doi>10.1177/000348940611500904</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-4894 |
| ispartof | Annals of otology, rhinology & laryngology, 2006-09, Vol.115 (9), p.673-678 |
| issn | 0003-4894 1943-572X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68965143 |
| source | SAGE Complete A-Z List; MEDLINE |
| subjects | Administration, Topical Adolescent Adult Aged Antibiotics, Antineoplastic - therapeutic use Biological and medical sciences Chronic Disease Cicatrix - prevention & control Constriction, Pathologic - prevention & control Endoscopy Female Humans Male Maxillary Sinus - pathology Maxillary Sinus - surgery Maxillary Sinusitis - surgery Medical sciences Middle Aged Mitomycin - therapeutic use Otorhinolaryngology. Stomatology Postoperative Complications - prevention & control |
| title | Effect of Mitomycin C on the Size of Antrostomy after Endoscopic Sinus Surgery |
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