Comparison of the anti-neoplastic effects of dirhodium(II) tetrapropionate and its adducts with nicotinate and isonicotinate anions in mice bearing Ehrlich tumors
Rhodium(II) propionate, [Rh 2(prop) 4], and its adduct with nicotinate (nic –) and isonicotinate (isonic –) anions, [Rh 2(prop) 4(nic) 2] 2– and [Rh 2(prop) 4(isonic) 2] 2–, respectively, were prepared for study. The compound effects on the survival rate of mice bearing Ehrlich ascites tumors were t...
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| Veröffentlicht in: | European journal of medicinal chemistry 2006-10, Vol.41 (10), p.1214-1216 |
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| creator | de Souza, Aparecido Ribeiro Coelho, Eliel Pereira Zyngier, Szulim Ber |
| description | Rhodium(II) propionate, [Rh
2(prop)
4], and its adduct with nicotinate (nic
–) and isonicotinate (isonic
–) anions, [Rh
2(prop)
4(nic)
2]
2– and [Rh
2(prop)
4(isonic)
2]
2–, respectively, were prepared for study. The compound effects on the survival rate of mice bearing Ehrlich ascites tumors were tested and presented in the form of a survival table, and analyzed by the Mantel–Haenszel chi-square test for N animals in each group. The survival rates of animals were significantly higher than that of control group (
P
<
0.001) without distinguishing among the experimental groups. The estimated probability for an animal in the control group to survive up to the end of the observation period (30 days) was below 33%, whereas the animal groups in the treated group with complex, and its nicotinate and isonicotinate groups showed 85%, 85% and 90%, respectively, of surviving over the same period. The
T/
C values (survival average of the animals treated group/survival average of the animals control group) were obtained for each compounds being for the dirhodium propionate
T/
C
=
250, and for its adducts with nicotinate and isonicotinate anions, 267 and 264, respectively. |
| doi_str_mv | 10.1016/j.ejmech.2006.05.016 |
| format | Article |
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2(prop)
4], and its adduct with nicotinate (nic
–) and isonicotinate (isonic
–) anions, [Rh
2(prop)
4(nic)
2]
2– and [Rh
2(prop)
4(isonic)
2]
2–, respectively, were prepared for study. The compound effects on the survival rate of mice bearing Ehrlich ascites tumors were tested and presented in the form of a survival table, and analyzed by the Mantel–Haenszel chi-square test for N animals in each group. The survival rates of animals were significantly higher than that of control group (
P
<
0.001) without distinguishing among the experimental groups. The estimated probability for an animal in the control group to survive up to the end of the observation period (30 days) was below 33%, whereas the animal groups in the treated group with complex, and its nicotinate and isonicotinate groups showed 85%, 85% and 90%, respectively, of surviving over the same period. The
T/
C values (survival average of the animals treated group/survival average of the animals control group) were obtained for each compounds being for the dirhodium propionate
T/
C
=
250, and for its adducts with nicotinate and isonicotinate anions, 267 and 264, respectively.</description><identifier>ISSN: 0223-5234</identifier><identifier>EISSN: 1768-3254</identifier><identifier>DOI: 10.1016/j.ejmech.2006.05.016</identifier><identifier>PMID: 16822594</identifier><identifier>CODEN: EJMCA5</identifier><language>eng</language><publisher>Oxford: Elsevier Masson SAS</publisher><subject>Animals ; Anions - chemistry ; Anti-tumor ; Antineoplastic agents ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Biological and medical sciences ; Carboxylate ; Carcinoma, Ehrlich Tumor - drug therapy ; Drug Screening Assays, Antitumor ; Ehrlich tumors ; Female ; General aspects ; Isonicotinic Acids - chemistry ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Molecular Structure ; Niacin - chemistry ; Organometallic Compounds - chemical synthesis ; Organometallic Compounds - chemistry ; Organometallic Compounds - pharmacology ; Pharmacology. Drug treatments ; Propionates - chemistry ; Rhodium ; Rhodium - chemistry ; Survival Rate ; Xenograft Model Antitumor Assays</subject><ispartof>European journal of medicinal chemistry, 2006-10, Vol.41 (10), p.1214-1216</ispartof><rights>2006 Elsevier Masson SAS</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-b1b6b298418bfc8b8c59fafdb4acace304870609890bc2a33bc4a47e98ddbe623</citedby><cites>FETCH-LOGICAL-c390t-b1b6b298418bfc8b8c59fafdb4acace304870609890bc2a33bc4a47e98ddbe623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejmech.2006.05.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18217848$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16822594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Souza, Aparecido Ribeiro</creatorcontrib><creatorcontrib>Coelho, Eliel Pereira</creatorcontrib><creatorcontrib>Zyngier, Szulim Ber</creatorcontrib><title>Comparison of the anti-neoplastic effects of dirhodium(II) tetrapropionate and its adducts with nicotinate and isonicotinate anions in mice bearing Ehrlich tumors</title><title>European journal of medicinal chemistry</title><addtitle>Eur J Med Chem</addtitle><description>Rhodium(II) propionate, [Rh
2(prop)
4], and its adduct with nicotinate (nic
–) and isonicotinate (isonic
–) anions, [Rh
2(prop)
4(nic)
2]
2– and [Rh
2(prop)
4(isonic)
2]
2–, respectively, were prepared for study. The compound effects on the survival rate of mice bearing Ehrlich ascites tumors were tested and presented in the form of a survival table, and analyzed by the Mantel–Haenszel chi-square test for N animals in each group. The survival rates of animals were significantly higher than that of control group (
P
<
0.001) without distinguishing among the experimental groups. The estimated probability for an animal in the control group to survive up to the end of the observation period (30 days) was below 33%, whereas the animal groups in the treated group with complex, and its nicotinate and isonicotinate groups showed 85%, 85% and 90%, respectively, of surviving over the same period. The
T/
C values (survival average of the animals treated group/survival average of the animals control group) were obtained for each compounds being for the dirhodium propionate
T/
C
=
250, and for its adducts with nicotinate and isonicotinate anions, 267 and 264, respectively.</description><subject>Animals</subject><subject>Anions - chemistry</subject><subject>Anti-tumor</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carboxylate</subject><subject>Carcinoma, Ehrlich Tumor - drug therapy</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Ehrlich tumors</subject><subject>Female</subject><subject>General aspects</subject><subject>Isonicotinic Acids - chemistry</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Molecular Structure</subject><subject>Niacin - chemistry</subject><subject>Organometallic Compounds - chemical synthesis</subject><subject>Organometallic Compounds - chemistry</subject><subject>Organometallic Compounds - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Propionates - chemistry</subject><subject>Rhodium</subject><subject>Rhodium - chemistry</subject><subject>Survival Rate</subject><subject>Xenograft Model Antitumor Assays</subject><issn>0223-5234</issn><issn>1768-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS1ERYfCGyCUDQgWCY7jeJwNEhoVOlKlbmBt-eeGeJTYwXaKeJvZ8hrzZHiYkdpVV5aOvnN87z0IvalxVeOafdpVsJtADxXBmFW4rbL4DK3qNeNlQ1r6HK0wIU3ZkoZeopcx7jDGLcP4BbqsGSek7egK_d34aZbBRu8K3x_2aYDDXrpkSwd-HmVMVhfQ96BT_A8YGwZv7DJ92G4_FglSkHPws_VOJiikM4e9TTFnGLMcPb9tGgpntU_2EZG_eyxldyysO-wnq6FQkAdyP4vrIYxWD0VaJh_iK3TRyzHC6_N7hX58vf6-uSlv775tN19uS910OJWqVkyRjtOaq15zxXXb9bI3ikotNTSY8jVmuOMdVprIplGaSrqGjhujgJHmCr0_5ea1fi0Qk5hs1DCOMl9kiYLxjtGGHkF6AnXwMQboxRzsJMMfUWNxrEjsxKkicaxI4FZkMdvenvMXNYF5MJ07ycC7MyCjlmMfpNM2PnCc1GtOeeY-nzjI17i3EETUFpyGXFGuSxhvn57kH-3WvCQ</recordid><startdate>20061001</startdate><enddate>20061001</enddate><creator>de Souza, Aparecido Ribeiro</creator><creator>Coelho, Eliel Pereira</creator><creator>Zyngier, Szulim Ber</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061001</creationdate><title>Comparison of the anti-neoplastic effects of dirhodium(II) tetrapropionate and its adducts with nicotinate and isonicotinate anions in mice bearing Ehrlich tumors</title><author>de Souza, Aparecido Ribeiro ; Coelho, Eliel Pereira ; Zyngier, Szulim Ber</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-b1b6b298418bfc8b8c59fafdb4acace304870609890bc2a33bc4a47e98ddbe623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Anions - chemistry</topic><topic>Anti-tumor</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Carboxylate</topic><topic>Carcinoma, Ehrlich Tumor - drug therapy</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Ehrlich tumors</topic><topic>Female</topic><topic>General aspects</topic><topic>Isonicotinic Acids - chemistry</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Molecular Structure</topic><topic>Niacin - chemistry</topic><topic>Organometallic Compounds - chemical synthesis</topic><topic>Organometallic Compounds - chemistry</topic><topic>Organometallic Compounds - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Propionates - chemistry</topic><topic>Rhodium</topic><topic>Rhodium - chemistry</topic><topic>Survival Rate</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Souza, Aparecido Ribeiro</creatorcontrib><creatorcontrib>Coelho, Eliel Pereira</creatorcontrib><creatorcontrib>Zyngier, Szulim Ber</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Souza, Aparecido Ribeiro</au><au>Coelho, Eliel Pereira</au><au>Zyngier, Szulim Ber</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the anti-neoplastic effects of dirhodium(II) tetrapropionate and its adducts with nicotinate and isonicotinate anions in mice bearing Ehrlich tumors</atitle><jtitle>European journal of medicinal chemistry</jtitle><addtitle>Eur J Med Chem</addtitle><date>2006-10-01</date><risdate>2006</risdate><volume>41</volume><issue>10</issue><spage>1214</spage><epage>1216</epage><pages>1214-1216</pages><issn>0223-5234</issn><eissn>1768-3254</eissn><coden>EJMCA5</coden><abstract>Rhodium(II) propionate, [Rh
2(prop)
4], and its adduct with nicotinate (nic
–) and isonicotinate (isonic
–) anions, [Rh
2(prop)
4(nic)
2]
2– and [Rh
2(prop)
4(isonic)
2]
2–, respectively, were prepared for study. The compound effects on the survival rate of mice bearing Ehrlich ascites tumors were tested and presented in the form of a survival table, and analyzed by the Mantel–Haenszel chi-square test for N animals in each group. The survival rates of animals were significantly higher than that of control group (
P
<
0.001) without distinguishing among the experimental groups. The estimated probability for an animal in the control group to survive up to the end of the observation period (30 days) was below 33%, whereas the animal groups in the treated group with complex, and its nicotinate and isonicotinate groups showed 85%, 85% and 90%, respectively, of surviving over the same period. The
T/
C values (survival average of the animals treated group/survival average of the animals control group) were obtained for each compounds being for the dirhodium propionate
T/
C
=
250, and for its adducts with nicotinate and isonicotinate anions, 267 and 264, respectively.</abstract><cop>Oxford</cop><pub>Elsevier Masson SAS</pub><pmid>16822594</pmid><doi>10.1016/j.ejmech.2006.05.016</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0223-5234 |
| ispartof | European journal of medicinal chemistry, 2006-10, Vol.41 (10), p.1214-1216 |
| issn | 0223-5234 1768-3254 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68964342 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Anions - chemistry Anti-tumor Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Carboxylate Carcinoma, Ehrlich Tumor - drug therapy Drug Screening Assays, Antitumor Ehrlich tumors Female General aspects Isonicotinic Acids - chemistry Medical sciences Mice Mice, Inbred BALB C Molecular Structure Niacin - chemistry Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Pharmacology. Drug treatments Propionates - chemistry Rhodium Rhodium - chemistry Survival Rate Xenograft Model Antitumor Assays |
| title | Comparison of the anti-neoplastic effects of dirhodium(II) tetrapropionate and its adducts with nicotinate and isonicotinate anions in mice bearing Ehrlich tumors |
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