Stereoelectronic Effects Dictate Mechanistic Dichotomy between Cu(II)-Catalyzed and Enzyme-Catalyzed Reactions of Malonic Acid Half Thioesters

Previously we developed a Cu(II)-catalyzed, enantioselective aldol reaction between malonic acid half thioesters (MAHTs) and aldehydes based on the biosynthesis of polyketides and fatty acids in which MAHTs are decarboxylated enzymatically to afford ester enolates that condense with thioesters. We r...

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Veröffentlicht in:	Journal of the American Chemical Society 2007-02, Vol.129 (5), p.1032-1033
Hauptverfasser:	Fortner, Kevin C, Shair, Matthew D
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - chemistry Catalysis Cations, Divalent Copper - chemistry Enzyme Activation Esters - chemistry Kinetics Malonates - chemistry Models, Chemical Sulfhydryl Compounds - chemistry
Online-Zugang:	Volltext
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