Large-scale generation of highly enriched neural stem-cell-derived oligodendroglial cultures: maturation-dependent differences in insulin-like growth factor-mediated signal transduction

Multipotent neural stem cells (NSCs) are competent for commitment to the oligodendrocyte (OL) lineage both in vitro and in vivo. We exploited this property to develop a rat neurospheres (NS)/oligospheres (OS)-based culture system to generate large numbers of highly enriched late OL progenitors (preO...

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Veröffentlicht in:	Journal of neurochemistry 2007-02, Vol.100 (3), p.628-638
Hauptverfasser:	Broughton, Sarah K, Chen, Hanqin, Riddle, Art, Kuhn, Scott E, Nagalla, Srinivasa, Roberts, Charles T. Jr, Back, Stephen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt/protein kinase B Animals Animals, Newborn Biological and medical sciences Brain Tissue Transplantation - methods Cell Culture Techniques - methods Cell Differentiation - drug effects Cell Differentiation - physiology Cell Line, Tumor Cell Lineage - drug effects Cell Lineage - physiology Cell Proliferation - drug effects Cell Survival - drug effects Cell Survival - physiology Cells, Cultured Ciliary Neurotrophic Factor - metabolism Ciliary Neurotrophic Factor - pharmacology Culture Media, Conditioned - pharmacology Erk Extracellular Signal-Regulated MAP Kinases - drug effects Extracellular Signal-Regulated MAP Kinases - metabolism Fundamental and applied biological sciences. Psychology Gene expression Insulin Insulin Receptor Substrate Proteins Insulin-Like Growth Factor I - drug effects Insulin-Like Growth Factor I - metabolism Isolated neuron and nerve. Neuroglia Janus Kinase 1 - drug effects Janus Kinase 1 - metabolism Kinases Medical sciences Multipotent Stem Cells - drug effects Multipotent Stem Cells - metabolism myelin myelin sheath neural stem cell Neurology Neurons neurosphere oligodendrocyte Oligodendroglia - drug effects Oligodendroglia - metabolism Phosphoproteins - drug effects Phosphoproteins - metabolism Proto-Oncogene Proteins c-akt - drug effects Proto-Oncogene Proteins c-akt - metabolism Rats Rodents Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Somatomedins - metabolism Somatomedins - pharmacology Stem cells Stem Cells - drug effects Stem Cells - metabolism Triiodothyronine - metabolism Triiodothyronine - pharmacology Tumors of the nervous system. Phacomatoses Vertebrates: nervous system and sense organs
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