Fibroblast growth factor-2 enhances functional recovery of reinnervated muscle
Long‐term denervation of muscles results in fibrosis and fat replacement, which prevent muscles from regaining contractile function despite reinnervation. Therefore, prevention of muscle atrophy between nerve repair and muscle reinnervation may improve the functional outcome. A variety of growth fac...
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| Veröffentlicht in: | Muscle & nerve 2006-11, Vol.34 (5), p.623-630 |
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| creator | Iwata, Yoshihisa Ozaki, Noriyuki Hirata, Hitoshi Sugiura, Yasuo Horii, Emiko Nakao, Estuhiro Tatebe, Masahiro Yazaki, Naoya Hattori, Tatsuya Majima, Masataka Ishiguro, Naoki |
| description | Long‐term denervation of muscles results in fibrosis and fat replacement, which prevent muscles from regaining contractile function despite reinnervation. Therefore, prevention of muscle atrophy between nerve repair and muscle reinnervation may improve the functional outcome. A variety of growth factors play significant roles in muscle mass modulation and muscle regeneration. The purpose of the present study was to investigate the effect of fibroblast growth factor‐2 (FGF2) and nerve growth factor (NGF) on muscle mass modulation after denervation and reinnervation using a nerve‐to‐muscle neurotization model. Growth factors were injected into the anterior tibial muscle after direct neurotization of muscles every 7 days up to 4 weeks after surgery. FGF2 significantly increased the amplitude of compound muscle action potentials (CMAPs), wet muscle weight, and the number of motor endplates, especially at higher concentration, compared to the vehicle. In contrast, NGF did not increase either the amplitude of CMAPs or muscle weight, although it significantly increased the number of motor endplates. These findings indicate that both growth factors enhance reinnervation of muscles; however, only FGF2 is involved in muscle mass modulation. Muscle Nerve, 2006 |
| doi_str_mv | 10.1002/mus.20634 |
| format | Article |
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Therefore, prevention of muscle atrophy between nerve repair and muscle reinnervation may improve the functional outcome. A variety of growth factors play significant roles in muscle mass modulation and muscle regeneration. The purpose of the present study was to investigate the effect of fibroblast growth factor‐2 (FGF2) and nerve growth factor (NGF) on muscle mass modulation after denervation and reinnervation using a nerve‐to‐muscle neurotization model. Growth factors were injected into the anterior tibial muscle after direct neurotization of muscles every 7 days up to 4 weeks after surgery. FGF2 significantly increased the amplitude of compound muscle action potentials (CMAPs), wet muscle weight, and the number of motor endplates, especially at higher concentration, compared to the vehicle. In contrast, NGF did not increase either the amplitude of CMAPs or muscle weight, although it significantly increased the number of motor endplates. These findings indicate that both growth factors enhance reinnervation of muscles; however, only FGF2 is involved in muscle mass modulation. Muscle Nerve, 2006</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.20634</identifier><identifier>PMID: 16929545</identifier><identifier>CODEN: MUNEDE</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>acetylcholinesterase ; Action Potentials - drug effects ; Action Potentials - physiology ; Animals ; Biological and medical sciences ; Denervation ; Disease Models, Animal ; Fibroblast Growth Factor 2 - metabolism ; Fibroblast Growth Factor 2 - pharmacology ; Fibroblast Growth Factor 2 - therapeutic use ; fibroblast growth factor-2 ; Fundamental and applied biological sciences. Psychology ; Male ; Motor Neurons - drug effects ; Motor Neurons - physiology ; Motor Neurons - transplantation ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - innervation ; Muscle, Skeletal - physiopathology ; Muscular Atrophy - drug therapy ; Muscular Atrophy - physiopathology ; Muscular Atrophy - prevention & control ; nerve growth factor ; Nerve Growth Factor - metabolism ; Nerve Growth Factor - pharmacology ; Nerve Growth Factor - therapeutic use ; neuromuscular junction ; Neuromuscular Junction - drug effects ; Neuromuscular Junction - physiology ; neurotization ; Organ Size - drug effects ; Organ Size - physiology ; Peripheral Nerves - anatomy & histology ; Peripheral Nerves - physiology ; Peripheral Nerves - transplantation ; Rats ; Rats, Wistar ; Recovery of Function - drug effects ; Recovery of Function - physiology ; Regeneration - drug effects ; Regeneration - physiology ; Striated muscle. Tendons ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Muscle & nerve, 2006-11, Vol.34 (5), p.623-630</ispartof><rights>Copyright © 2006 Wiley Periodicals, Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4574-c8fab6c31d62ae1da165569983436a856ee74101618a66c81d2e5a0fdc7085893</citedby><cites>FETCH-LOGICAL-c4574-c8fab6c31d62ae1da165569983436a856ee74101618a66c81d2e5a0fdc7085893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.20634$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.20634$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18237635$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16929545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iwata, Yoshihisa</creatorcontrib><creatorcontrib>Ozaki, Noriyuki</creatorcontrib><creatorcontrib>Hirata, Hitoshi</creatorcontrib><creatorcontrib>Sugiura, Yasuo</creatorcontrib><creatorcontrib>Horii, Emiko</creatorcontrib><creatorcontrib>Nakao, Estuhiro</creatorcontrib><creatorcontrib>Tatebe, Masahiro</creatorcontrib><creatorcontrib>Yazaki, Naoya</creatorcontrib><creatorcontrib>Hattori, Tatsuya</creatorcontrib><creatorcontrib>Majima, Masataka</creatorcontrib><creatorcontrib>Ishiguro, Naoki</creatorcontrib><title>Fibroblast growth factor-2 enhances functional recovery of reinnervated muscle</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Long‐term denervation of muscles results in fibrosis and fat replacement, which prevent muscles from regaining contractile function despite reinnervation. Therefore, prevention of muscle atrophy between nerve repair and muscle reinnervation may improve the functional outcome. A variety of growth factors play significant roles in muscle mass modulation and muscle regeneration. The purpose of the present study was to investigate the effect of fibroblast growth factor‐2 (FGF2) and nerve growth factor (NGF) on muscle mass modulation after denervation and reinnervation using a nerve‐to‐muscle neurotization model. Growth factors were injected into the anterior tibial muscle after direct neurotization of muscles every 7 days up to 4 weeks after surgery. FGF2 significantly increased the amplitude of compound muscle action potentials (CMAPs), wet muscle weight, and the number of motor endplates, especially at higher concentration, compared to the vehicle. In contrast, NGF did not increase either the amplitude of CMAPs or muscle weight, although it significantly increased the number of motor endplates. These findings indicate that both growth factors enhance reinnervation of muscles; however, only FGF2 is involved in muscle mass modulation. Muscle Nerve, 2006</description><subject>acetylcholinesterase</subject><subject>Action Potentials - drug effects</subject><subject>Action Potentials - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Denervation</subject><subject>Disease Models, Animal</subject><subject>Fibroblast Growth Factor 2 - metabolism</subject><subject>Fibroblast Growth Factor 2 - pharmacology</subject><subject>Fibroblast Growth Factor 2 - therapeutic use</subject><subject>fibroblast growth factor-2</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Motor Neurons - drug effects</subject><subject>Motor Neurons - physiology</subject><subject>Motor Neurons - transplantation</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - innervation</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Muscular Atrophy - drug therapy</subject><subject>Muscular Atrophy - physiopathology</subject><subject>Muscular Atrophy - prevention & control</subject><subject>nerve growth factor</subject><subject>Nerve Growth Factor - metabolism</subject><subject>Nerve Growth Factor - pharmacology</subject><subject>Nerve Growth Factor - therapeutic use</subject><subject>neuromuscular junction</subject><subject>Neuromuscular Junction - drug effects</subject><subject>Neuromuscular Junction - physiology</subject><subject>neurotization</subject><subject>Organ Size - drug effects</subject><subject>Organ Size - physiology</subject><subject>Peripheral Nerves - anatomy & histology</subject><subject>Peripheral Nerves - physiology</subject><subject>Peripheral Nerves - transplantation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Recovery of Function - drug effects</subject><subject>Recovery of Function - physiology</subject><subject>Regeneration - drug effects</subject><subject>Regeneration - physiology</subject><subject>Striated muscle. Tendons</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1PFEEQBuAOkciKHvwDZi6aeBjoz5ruo27chQTxoETDpVPbUyMDs9PYPQPuv3dgVzl5qjo89ZGXsdeCHwnO5fF6zEeSg9J7bCa4q0ptnH3GZlxoW4JyPw7Yi5yvOefCQvWcHQhw0hltZux80a5SXHWYh-JnivfDVdFgGGIqZUH9FfaBctGMfRja2GNXJArxjtKmiM3Ut31P6Q4Hqovph9DRS7bfYJfp1a4esovFp2_zk_Lsy_J0_uGsDNpUugy2wRUEJWqQSKJGAcaAc1ZpBWgNEFVacAHCIkCwopZkkDd1qLg11qlD9m679zbFXyPlwa_bHKjrsKc4Zg_WgbRaTvD9FoYUc07U-NvUrjFtvOD-ITw_Pe4fw5vsm93ScbWm-knu0prA2x3AHLBr0hRPm5-claoC9eCOt-6-7Wjz_4v-88XXv6fL7USbB_r9bwLTjYdKVcZ_P196aZeLj3N96aX6A-wxlPA</recordid><startdate>200611</startdate><enddate>200611</enddate><creator>Iwata, Yoshihisa</creator><creator>Ozaki, Noriyuki</creator><creator>Hirata, Hitoshi</creator><creator>Sugiura, Yasuo</creator><creator>Horii, Emiko</creator><creator>Nakao, Estuhiro</creator><creator>Tatebe, Masahiro</creator><creator>Yazaki, Naoya</creator><creator>Hattori, Tatsuya</creator><creator>Majima, Masataka</creator><creator>Ishiguro, Naoki</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200611</creationdate><title>Fibroblast growth factor-2 enhances functional recovery of reinnervated muscle</title><author>Iwata, Yoshihisa ; Ozaki, Noriyuki ; Hirata, Hitoshi ; Sugiura, Yasuo ; Horii, Emiko ; Nakao, Estuhiro ; Tatebe, Masahiro ; Yazaki, Naoya ; Hattori, Tatsuya ; Majima, Masataka ; Ishiguro, Naoki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4574-c8fab6c31d62ae1da165569983436a856ee74101618a66c81d2e5a0fdc7085893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>acetylcholinesterase</topic><topic>Action Potentials - drug effects</topic><topic>Action Potentials - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Denervation</topic><topic>Disease Models, Animal</topic><topic>Fibroblast Growth Factor 2 - metabolism</topic><topic>Fibroblast Growth Factor 2 - pharmacology</topic><topic>Fibroblast Growth Factor 2 - therapeutic use</topic><topic>fibroblast growth factor-2</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Motor Neurons - drug effects</topic><topic>Motor Neurons - physiology</topic><topic>Motor Neurons - transplantation</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - innervation</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Muscular Atrophy - drug therapy</topic><topic>Muscular Atrophy - physiopathology</topic><topic>Muscular Atrophy - prevention & control</topic><topic>nerve growth factor</topic><topic>Nerve Growth Factor - metabolism</topic><topic>Nerve Growth Factor - pharmacology</topic><topic>Nerve Growth Factor - therapeutic use</topic><topic>neuromuscular junction</topic><topic>Neuromuscular Junction - drug effects</topic><topic>Neuromuscular Junction - physiology</topic><topic>neurotization</topic><topic>Organ Size - drug effects</topic><topic>Organ Size - physiology</topic><topic>Peripheral Nerves - anatomy & histology</topic><topic>Peripheral Nerves - physiology</topic><topic>Peripheral Nerves - transplantation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Recovery of Function - drug effects</topic><topic>Recovery of Function - physiology</topic><topic>Regeneration - drug effects</topic><topic>Regeneration - physiology</topic><topic>Striated muscle. Tendons</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iwata, Yoshihisa</creatorcontrib><creatorcontrib>Ozaki, Noriyuki</creatorcontrib><creatorcontrib>Hirata, Hitoshi</creatorcontrib><creatorcontrib>Sugiura, Yasuo</creatorcontrib><creatorcontrib>Horii, Emiko</creatorcontrib><creatorcontrib>Nakao, Estuhiro</creatorcontrib><creatorcontrib>Tatebe, Masahiro</creatorcontrib><creatorcontrib>Yazaki, Naoya</creatorcontrib><creatorcontrib>Hattori, Tatsuya</creatorcontrib><creatorcontrib>Majima, Masataka</creatorcontrib><creatorcontrib>Ishiguro, Naoki</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iwata, Yoshihisa</au><au>Ozaki, Noriyuki</au><au>Hirata, Hitoshi</au><au>Sugiura, Yasuo</au><au>Horii, Emiko</au><au>Nakao, Estuhiro</au><au>Tatebe, Masahiro</au><au>Yazaki, Naoya</au><au>Hattori, Tatsuya</au><au>Majima, Masataka</au><au>Ishiguro, Naoki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fibroblast growth factor-2 enhances functional recovery of reinnervated muscle</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2006-11</date><risdate>2006</risdate><volume>34</volume><issue>5</issue><spage>623</spage><epage>630</epage><pages>623-630</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><coden>MUNEDE</coden><abstract>Long‐term denervation of muscles results in fibrosis and fat replacement, which prevent muscles from regaining contractile function despite reinnervation. Therefore, prevention of muscle atrophy between nerve repair and muscle reinnervation may improve the functional outcome. A variety of growth factors play significant roles in muscle mass modulation and muscle regeneration. The purpose of the present study was to investigate the effect of fibroblast growth factor‐2 (FGF2) and nerve growth factor (NGF) on muscle mass modulation after denervation and reinnervation using a nerve‐to‐muscle neurotization model. Growth factors were injected into the anterior tibial muscle after direct neurotization of muscles every 7 days up to 4 weeks after surgery. FGF2 significantly increased the amplitude of compound muscle action potentials (CMAPs), wet muscle weight, and the number of motor endplates, especially at higher concentration, compared to the vehicle. In contrast, NGF did not increase either the amplitude of CMAPs or muscle weight, although it significantly increased the number of motor endplates. These findings indicate that both growth factors enhance reinnervation of muscles; however, only FGF2 is involved in muscle mass modulation. Muscle Nerve, 2006</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16929545</pmid><doi>10.1002/mus.20634</doi><tpages>8</tpages></addata></record> |
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| subjects | acetylcholinesterase Action Potentials - drug effects Action Potentials - physiology Animals Biological and medical sciences Denervation Disease Models, Animal Fibroblast Growth Factor 2 - metabolism Fibroblast Growth Factor 2 - pharmacology Fibroblast Growth Factor 2 - therapeutic use fibroblast growth factor-2 Fundamental and applied biological sciences. Psychology Male Motor Neurons - drug effects Motor Neurons - physiology Motor Neurons - transplantation Muscle, Skeletal - drug effects Muscle, Skeletal - innervation Muscle, Skeletal - physiopathology Muscular Atrophy - drug therapy Muscular Atrophy - physiopathology Muscular Atrophy - prevention & control nerve growth factor Nerve Growth Factor - metabolism Nerve Growth Factor - pharmacology Nerve Growth Factor - therapeutic use neuromuscular junction Neuromuscular Junction - drug effects Neuromuscular Junction - physiology neurotization Organ Size - drug effects Organ Size - physiology Peripheral Nerves - anatomy & histology Peripheral Nerves - physiology Peripheral Nerves - transplantation Rats Rats, Wistar Recovery of Function - drug effects Recovery of Function - physiology Regeneration - drug effects Regeneration - physiology Striated muscle. Tendons Vertebrates: osteoarticular system, musculoskeletal system |
| title | Fibroblast growth factor-2 enhances functional recovery of reinnervated muscle |
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