Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo

The mouse Kcnq1 imprinted domain is located on distal chromosome 7 and contains several imprinted genes that are paternally repressed. Repression of these genes is regulated by a non-coding antisense transcript, Kcnq1ot1 , which is paternally expressed. Maternal repression of Kcnq1ot1 is controlled...

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Veröffentlicht in:	Development (Cambridge) 2006-11, Vol.133 (21), p.4203-4210
Hauptverfasser:	Lewis, Annabelle, Green, Kelly, Dawson, Claire, Redrup, Lisa, Huynh, Khanh D, Lee, Jeannie T, Hemberger, Myriam, Reik, Wolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Blastocyst - physiology Cell Differentiation - physiology Cell Lineage DNA Methylation Embryonic Stem Cells - cytology Embryonic Stem Cells - physiology Epigenesis, Genetic Gene Expression Regulation, Developmental Gene Silencing Genomic Imprinting Histones - metabolism KCNQ1 Potassium Channel - genetics KCNQ1 Potassium Channel - metabolism Mice Mice, Inbred C57BL Oligonucleotides, Antisense - genetics Oligonucleotides, Antisense - metabolism Placenta - cytology Placenta - physiology Trophoblasts - cytology Trophoblasts - physiology X Chromosome Inactivation
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