Fluoxetine Modulates the Circadian Biological Clock via Phase Advances of Suprachiasmatic Nucleus Neuronal Firing
The documented ability of serotonin (5-HT) to directly modulate circadian rhythms prompted interest in a similar role for therapeutic agents that readily enhance 5-HT neurotransmission, namely the selective serotonin reuptake inhibitors (SSRIs). Extracellular recordings of unit firing of suprachiasm...
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| Veröffentlicht in: | Biological psychiatry (1969) 2006-10, Vol.60 (8), p.896-899 |
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| container_title | Biological psychiatry (1969) |
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| creator | Sprouse, Jeffrey Braselton, John Reynolds, Linda |
| description | The documented ability of serotonin (5-HT) to directly modulate circadian rhythms prompted interest in a similar role for therapeutic agents that readily enhance 5-HT neurotransmission, namely the selective serotonin reuptake inhibitors (SSRIs).
Extracellular recordings of unit firing of suprachiasmatic nucleus (SCN) neurons maintained in slice culture enabled determinations of circadian rhythmicity. Shifts in the peak of activity were determined during the next circadian cycle following drug exposure.
Fluoxetine (10 μm, 60 minutes incubation) produced robust phase advances only in the presence of L-tryptophan (.5 μm), added to maintain serotonergic tone.
Actions of SSRIs at the level of the circadian biological clock add to the list of pharmacological effects for this drug class and encourage speculation as to their importance clinically. |
| doi_str_mv | 10.1016/j.biopsych.2006.03.003 |
| format | Article |
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Extracellular recordings of unit firing of suprachiasmatic nucleus (SCN) neurons maintained in slice culture enabled determinations of circadian rhythmicity. Shifts in the peak of activity were determined during the next circadian cycle following drug exposure.
Fluoxetine (10 μm, 60 minutes incubation) produced robust phase advances only in the presence of L-tryptophan (.5 μm), added to maintain serotonergic tone.
Actions of SSRIs at the level of the circadian biological clock add to the list of pharmacological effects for this drug class and encourage speculation as to their importance clinically.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/j.biopsych.2006.03.003</identifier><identifier>PMID: 16631132</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Circadian Rhythm - drug effects ; circadian rhythms ; Electric Stimulation ; Electrophysiology ; fluoxetine ; Fluoxetine - pharmacology ; L-tryptophan ; Male ; Medical sciences ; Neurons - drug effects ; Neurons - physiology ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychopharmacology ; Rats ; Rats, Sprague-Dawley ; Serotonin ; Serotonin - metabolism ; Serotonin Uptake Inhibitors - pharmacology ; SSRI ; suprachiasmatic nucleus ; Suprachiasmatic Nucleus - cytology ; Suprachiasmatic Nucleus - drug effects ; Suprachiasmatic Nucleus - physiology ; Tryptophan - pharmacology</subject><ispartof>Biological psychiatry (1969), 2006-10, Vol.60 (8), p.896-899</ispartof><rights>2006 Society of Biological Psychiatry</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-f46cde57e87399546acefb2830a3310b0e8101ddb5992e6f522cd437115317463</citedby><cites>FETCH-LOGICAL-c427t-f46cde57e87399546acefb2830a3310b0e8101ddb5992e6f522cd437115317463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006322306002976$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18224892$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16631132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sprouse, Jeffrey</creatorcontrib><creatorcontrib>Braselton, John</creatorcontrib><creatorcontrib>Reynolds, Linda</creatorcontrib><title>Fluoxetine Modulates the Circadian Biological Clock via Phase Advances of Suprachiasmatic Nucleus Neuronal Firing</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>The documented ability of serotonin (5-HT) to directly modulate circadian rhythms prompted interest in a similar role for therapeutic agents that readily enhance 5-HT neurotransmission, namely the selective serotonin reuptake inhibitors (SSRIs).
Extracellular recordings of unit firing of suprachiasmatic nucleus (SCN) neurons maintained in slice culture enabled determinations of circadian rhythmicity. Shifts in the peak of activity were determined during the next circadian cycle following drug exposure.
Fluoxetine (10 μm, 60 minutes incubation) produced robust phase advances only in the presence of L-tryptophan (.5 μm), added to maintain serotonergic tone.
Actions of SSRIs at the level of the circadian biological clock add to the list of pharmacological effects for this drug class and encourage speculation as to their importance clinically.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Circadian Rhythm - drug effects</subject><subject>circadian rhythms</subject><subject>Electric Stimulation</subject><subject>Electrophysiology</subject><subject>fluoxetine</subject><subject>Fluoxetine - pharmacology</subject><subject>L-tryptophan</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Serotonin</topic><topic>Serotonin - metabolism</topic><topic>Serotonin Uptake Inhibitors - pharmacology</topic><topic>SSRI</topic><topic>suprachiasmatic nucleus</topic><topic>Suprachiasmatic Nucleus - cytology</topic><topic>Suprachiasmatic Nucleus - drug effects</topic><topic>Suprachiasmatic Nucleus - physiology</topic><topic>Tryptophan - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sprouse, Jeffrey</creatorcontrib><creatorcontrib>Braselton, John</creatorcontrib><creatorcontrib>Reynolds, Linda</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sprouse, Jeffrey</au><au>Braselton, John</au><au>Reynolds, Linda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fluoxetine Modulates the Circadian Biological Clock via Phase Advances of Suprachiasmatic Nucleus Neuronal Firing</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2006-10-15</date><risdate>2006</risdate><volume>60</volume><issue>8</issue><spage>896</spage><epage>899</epage><pages>896-899</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>The documented ability of serotonin (5-HT) to directly modulate circadian rhythms prompted interest in a similar role for therapeutic agents that readily enhance 5-HT neurotransmission, namely the selective serotonin reuptake inhibitors (SSRIs).
Extracellular recordings of unit firing of suprachiasmatic nucleus (SCN) neurons maintained in slice culture enabled determinations of circadian rhythmicity. Shifts in the peak of activity were determined during the next circadian cycle following drug exposure.
Fluoxetine (10 μm, 60 minutes incubation) produced robust phase advances only in the presence of L-tryptophan (.5 μm), added to maintain serotonergic tone.
Actions of SSRIs at the level of the circadian biological clock add to the list of pharmacological effects for this drug class and encourage speculation as to their importance clinically.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16631132</pmid><doi>10.1016/j.biopsych.2006.03.003</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Circadian Rhythm - drug effects circadian rhythms Electric Stimulation Electrophysiology fluoxetine Fluoxetine - pharmacology L-tryptophan Male Medical sciences Neurons - drug effects Neurons - physiology Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Serotonin Serotonin - metabolism Serotonin Uptake Inhibitors - pharmacology SSRI suprachiasmatic nucleus Suprachiasmatic Nucleus - cytology Suprachiasmatic Nucleus - drug effects Suprachiasmatic Nucleus - physiology Tryptophan - pharmacology |
| title | Fluoxetine Modulates the Circadian Biological Clock via Phase Advances of Suprachiasmatic Nucleus Neuronal Firing |
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