Manganese transport and the role of manganese in virulence
Two areas of research have recently converged to highlight important roles for Mn(2+) in pathogenesis: the recognition that both bacterial Nramp homologs and members of LraI family of proteins are Mn(2+) transporters. Their mutation is associated with decreased virulence of various bacterial species...
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| Veröffentlicht in: | Annual review of microbiology 2006-01, Vol.60 (1), p.187-209 |
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| creator | PAPP-WALLACE, Krisztina M MAGUIRE, Michael E |
| description | Two areas of research have recently converged to highlight important roles for Mn(2+) in pathogenesis: the recognition that both bacterial Nramp homologs and members of LraI family of proteins are Mn(2+) transporters. Their mutation is associated with decreased virulence of various bacterial species. Thus, Mn(2+) appears to be essential for bacterial virulence. This review describes what is currently known about Mn(2+) transport in prokaryotes and how prokaryotic Mn(2+) transport is regulated. Some of the phenotypes that arise when microorganisms lack Mn(2+) are then discussed, with an emphasis on those phenotypes involving pathogenesis. The concluding section describes possible enzymatic roles for Mn(2+) that might help explain why Mn(2+) is necessary for virulence. |
| doi_str_mv | 10.1146/annurev.micro.60.080805.142149 |
| format | Article |
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Their mutation is associated with decreased virulence of various bacterial species. Thus, Mn(2+) appears to be essential for bacterial virulence. This review describes what is currently known about Mn(2+) transport in prokaryotes and how prokaryotic Mn(2+) transport is regulated. Some of the phenotypes that arise when microorganisms lack Mn(2+) are then discussed, with an emphasis on those phenotypes involving pathogenesis. 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| ispartof | Annual review of microbiology, 2006-01, Vol.60 (1), p.187-209 |
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| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | Animals ATP-Binding Cassette Transporters - physiology Bacillus anthracis - metabolism Bacillus anthracis - pathogenicity Bacteria Bacteria - metabolism Bacteria - pathogenicity Bacterial Proteins - physiology Bacteriology Biological and medical sciences Biological Transport Carbon - metabolism Cation Transport Proteins - physiology Chemical elements Fundamental and applied biological sciences. Psychology Manganese Manganese - physiology Mice Microbiology Microorganisms Miscellaneous Mycobacterium tuberculosis - metabolism Mycobacterium tuberculosis - pathogenicity Pathology Phosphorylation Repressor Proteins - physiology Salmonella typhimurium - metabolism Salmonella typhimurium - pathogenicity Streptococcus - metabolism Streptococcus - pathogenicity Virulence |
| title | Manganese transport and the role of manganese in virulence |
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