Impact of Vitamin A on Selected Gastrointestinal Pathogen Infections and Associated Diarrheal Episodes among Children in Mexico City, Mexico
BackgroundThe overall effect of vitamin A supplementation on diarrheal disease in community trials may result from its effect on specific diarrheal pathogens MethodsWe conducted a placebo-controlled, double-blind trial of the prophylactic effect of vitamin A on gastrointestinal pathogen infections a...
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| Veröffentlicht in: | The Journal of infectious diseases 2006-11, Vol.194 (9), p.1217-1225 |
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| container_title | The Journal of infectious diseases |
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| creator | Long, Kurt Z. Santos, Jose Ignacio Rosado, Jorge L. Lopez-Saucedo, Catalina Thompson-Bonilla, Rocio Abonce, Maricela DuPont, Herbert L. Hertzmark, Ellen Estrada-Garcia, Teresa |
| description | BackgroundThe overall effect of vitamin A supplementation on diarrheal disease in community trials may result from its effect on specific diarrheal pathogens MethodsWe conducted a placebo-controlled, double-blind trial of the prophylactic effect of vitamin A on gastrointestinal pathogen infections and clinical symptoms among 188 children in Mexico City, Mexico, from January 1998 to May 1999. Children 6–15 months of age were randomly assigned to receive either a vitamin A supplement (for children |
| doi_str_mv | 10.1086/508292 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_68957580</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>30085918</jstor_id><oup_id>10.1086/508292</oup_id><sourcerecordid>30085918</sourcerecordid><originalsourceid>FETCH-LOGICAL-c522t-b61656969645b297f097fd218ef32410836e28986d6ee9bcd33f5b324b87176f3</originalsourceid><addsrcrecordid>eNqFkdtu1DAQhiMEotsCbwAyF3BFwIf4dLlsTyttAYmCVtxYTuJ03Sb2Ynul9h14aLxK1L1CyBpZ1v_NjGf-oniF4EcEBftEocASPylmiBJeMobI02IGIcYlElIeFccx3kIIK8L48-IIcVghUfFZ8Wc5bHWTgO_AT5v0YB2YA-_Ad9ObJpkWXOiYgrcumZis0z34ptPG3xgHlq7LiPUuAu1aMI_RN1bvc06tDmFjMny2tdG3JhODdzdgsbF9G3JubnNl7m3jwcKmhw_T40XxrNN9NC-n-6T4cX52vbgsV18vlov5qmwoxqmsGWKUyXwqWmPJO5ijxUiYjuAqr4Mwg4UUrGXGyLppCelonaVacMRZR06K92PdbfC_d3kwNdjYmL7XzvhdVExIyqmA_wWRJIIhiQ5gE3yMwXRqG-ygw4NCUO0NUqNBGXwzVdzVg2kP2ORIBt5NgI6N7rugXWPjgRM4D8L3X3s7cn63_Xez1yNzG5MPjxSBUFCJRNbLUbcxmftHXYc7xTjhVF2uf6nz9We2ur76otbkL2UGugg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19386191</pqid></control><display><type>article</type><title>Impact of Vitamin A on Selected Gastrointestinal Pathogen Infections and Associated Diarrheal Episodes among Children in Mexico City, Mexico</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Long, Kurt Z. ; Santos, Jose Ignacio ; Rosado, Jorge L. ; Lopez-Saucedo, Catalina ; Thompson-Bonilla, Rocio ; Abonce, Maricela ; DuPont, Herbert L. ; Hertzmark, Ellen ; Estrada-Garcia, Teresa</creator><creatorcontrib>Long, Kurt Z. ; Santos, Jose Ignacio ; Rosado, Jorge L. ; Lopez-Saucedo, Catalina ; Thompson-Bonilla, Rocio ; Abonce, Maricela ; DuPont, Herbert L. ; Hertzmark, Ellen ; Estrada-Garcia, Teresa</creatorcontrib><description>BackgroundThe overall effect of vitamin A supplementation on diarrheal disease in community trials may result from its effect on specific diarrheal pathogens MethodsWe conducted a placebo-controlled, double-blind trial of the prophylactic effect of vitamin A on gastrointestinal pathogen infections and clinical symptoms among 188 children in Mexico City, Mexico, from January 1998 to May 1999. Children 6–15 months of age were randomly assigned to receive either a vitamin A supplement (for children <12 months of age, 20,000 international units [IU] of retinol; for children ⩾12 months of age, 45,000 IU of retinol) every 2 months or a placebo and were followed for up to 15 months. Stool samples, collected semimonthly, were screened for enteropathogenic Escherichia coli (EPEC), enterotoxigenic E. coli (ETEC), Shiga toxin–producing E. coli (STEC), enteroinvasive E. coli (EIEC), and Giardia lamblia ResultsVitamin A supplementation reduced the prevalence of EPEC infections (rate ratio [RR], 0.52 [95% confidence interval {CI}, 0.23–0.86]) and led to shorter durations of both EPEC and ETEC infections. Supplementation also reduced the prevalence of EPEC-associated diarrhea (RR, 0.41 [95% CI, 0.16–1.00]), EPEC-associated fever (RR, 0.15 [95% CI, 0.02–0.98]), and G. lamblia–associated fever (RR, 0.27 [95% CI, 0.13–0.80]). Finally, children who received vitamin A supplementation had shorter durations of EPEC-associated diarrhea than did children who did not receive supplementation but had longer durations of G. lamblia–associated diarrhea ConclusionsThese results suggest that the effect of vitamin A supplementation on clinical outcomes may be pathogen dependent</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/508292</identifier><identifier>PMID: 17041847</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Bacteria ; Biological and medical sciences ; Child nutrition ; Communities ; Diarrhea ; Diarrhea - drug therapy ; Diarrhea - microbiology ; Diarrhea - prevention & control ; Digestive system ; Double-Blind Method ; Escherichia coli ; Escherichia coli Infections - drug therapy ; Escherichia coli Infections - prevention & control ; Female ; Fever ; Gastrointestinal Diseases - drug therapy ; Gastrointestinal Diseases - microbiology ; Gastrointestinal Diseases - prevention & control ; Giardia lamblia ; Giardiasis - drug therapy ; Giardiasis - prevention & control ; Humans ; Infant ; Infections ; Male ; Medical sciences ; Mexico - epidemiology ; Pathogens ; Pharmacology. Drug treatments ; Placebos ; Prevalence ; Regression analysis ; Vitamin A ; Vitamin A - therapeutic use</subject><ispartof>The Journal of infectious diseases, 2006-11, Vol.194 (9), p.1217-1225</ispartof><rights>Copyright 2006 Infectious Diseases Society of America</rights><rights>2006 by the Infectious Diseases Society of America 2006</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-b61656969645b297f097fd218ef32410836e28986d6ee9bcd33f5b324b87176f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30085918$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30085918$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18232470$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17041847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Long, Kurt Z.</creatorcontrib><creatorcontrib>Santos, Jose Ignacio</creatorcontrib><creatorcontrib>Rosado, Jorge L.</creatorcontrib><creatorcontrib>Lopez-Saucedo, Catalina</creatorcontrib><creatorcontrib>Thompson-Bonilla, Rocio</creatorcontrib><creatorcontrib>Abonce, Maricela</creatorcontrib><creatorcontrib>DuPont, Herbert L.</creatorcontrib><creatorcontrib>Hertzmark, Ellen</creatorcontrib><creatorcontrib>Estrada-Garcia, Teresa</creatorcontrib><title>Impact of Vitamin A on Selected Gastrointestinal Pathogen Infections and Associated Diarrheal Episodes among Children in Mexico City, Mexico</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>BackgroundThe overall effect of vitamin A supplementation on diarrheal disease in community trials may result from its effect on specific diarrheal pathogens MethodsWe conducted a placebo-controlled, double-blind trial of the prophylactic effect of vitamin A on gastrointestinal pathogen infections and clinical symptoms among 188 children in Mexico City, Mexico, from January 1998 to May 1999. Children 6–15 months of age were randomly assigned to receive either a vitamin A supplement (for children <12 months of age, 20,000 international units [IU] of retinol; for children ⩾12 months of age, 45,000 IU of retinol) every 2 months or a placebo and were followed for up to 15 months. Stool samples, collected semimonthly, were screened for enteropathogenic Escherichia coli (EPEC), enterotoxigenic E. coli (ETEC), Shiga toxin–producing E. coli (STEC), enteroinvasive E. coli (EIEC), and Giardia lamblia ResultsVitamin A supplementation reduced the prevalence of EPEC infections (rate ratio [RR], 0.52 [95% confidence interval {CI}, 0.23–0.86]) and led to shorter durations of both EPEC and ETEC infections. Supplementation also reduced the prevalence of EPEC-associated diarrhea (RR, 0.41 [95% CI, 0.16–1.00]), EPEC-associated fever (RR, 0.15 [95% CI, 0.02–0.98]), and G. lamblia–associated fever (RR, 0.27 [95% CI, 0.13–0.80]). Finally, children who received vitamin A supplementation had shorter durations of EPEC-associated diarrhea than did children who did not receive supplementation but had longer durations of G. lamblia–associated diarrhea ConclusionsThese results suggest that the effect of vitamin A supplementation on clinical outcomes may be pathogen dependent</description><subject>Bacteria</subject><subject>Biological and medical sciences</subject><subject>Child nutrition</subject><subject>Communities</subject><subject>Diarrhea</subject><subject>Diarrhea - drug therapy</subject><subject>Diarrhea - microbiology</subject><subject>Diarrhea - prevention & control</subject><subject>Digestive system</subject><subject>Double-Blind Method</subject><subject>Escherichia coli</subject><subject>Escherichia coli Infections - drug therapy</subject><subject>Escherichia coli Infections - prevention & control</subject><subject>Female</subject><subject>Fever</subject><subject>Gastrointestinal Diseases - drug therapy</subject><subject>Gastrointestinal Diseases - microbiology</subject><subject>Gastrointestinal Diseases - prevention & control</subject><subject>Giardia lamblia</subject><subject>Giardiasis - drug therapy</subject><subject>Giardiasis - prevention & control</subject><subject>Humans</subject><subject>Infant</subject><subject>Infections</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mexico - epidemiology</subject><subject>Pathogens</subject><subject>Pharmacology. Drug treatments</subject><subject>Placebos</subject><subject>Prevalence</subject><subject>Regression analysis</subject><subject>Vitamin A</subject><subject>Vitamin A - therapeutic use</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdtu1DAQhiMEotsCbwAyF3BFwIf4dLlsTyttAYmCVtxYTuJ03Sb2Ynul9h14aLxK1L1CyBpZ1v_NjGf-oniF4EcEBftEocASPylmiBJeMobI02IGIcYlElIeFccx3kIIK8L48-IIcVghUfFZ8Wc5bHWTgO_AT5v0YB2YA-_Ad9ObJpkWXOiYgrcumZis0z34ptPG3xgHlq7LiPUuAu1aMI_RN1bvc06tDmFjMny2tdG3JhODdzdgsbF9G3JubnNl7m3jwcKmhw_T40XxrNN9NC-n-6T4cX52vbgsV18vlov5qmwoxqmsGWKUyXwqWmPJO5ijxUiYjuAqr4Mwg4UUrGXGyLppCelonaVacMRZR06K92PdbfC_d3kwNdjYmL7XzvhdVExIyqmA_wWRJIIhiQ5gE3yMwXRqG-ygw4NCUO0NUqNBGXwzVdzVg2kP2ORIBt5NgI6N7rugXWPjgRM4D8L3X3s7cn63_Xez1yNzG5MPjxSBUFCJRNbLUbcxmftHXYc7xTjhVF2uf6nz9We2ur76otbkL2UGugg</recordid><startdate>20061101</startdate><enddate>20061101</enddate><creator>Long, Kurt Z.</creator><creator>Santos, Jose Ignacio</creator><creator>Rosado, Jorge L.</creator><creator>Lopez-Saucedo, Catalina</creator><creator>Thompson-Bonilla, Rocio</creator><creator>Abonce, Maricela</creator><creator>DuPont, Herbert L.</creator><creator>Hertzmark, Ellen</creator><creator>Estrada-Garcia, Teresa</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20061101</creationdate><title>Impact of Vitamin A on Selected Gastrointestinal Pathogen Infections and Associated Diarrheal Episodes among Children in Mexico City, Mexico</title><author>Long, Kurt Z. ; Santos, Jose Ignacio ; Rosado, Jorge L. ; Lopez-Saucedo, Catalina ; Thompson-Bonilla, Rocio ; Abonce, Maricela ; DuPont, Herbert L. ; Hertzmark, Ellen ; Estrada-Garcia, Teresa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-b61656969645b297f097fd218ef32410836e28986d6ee9bcd33f5b324b87176f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Bacteria</topic><topic>Biological and medical sciences</topic><topic>Child nutrition</topic><topic>Communities</topic><topic>Diarrhea</topic><topic>Diarrhea - drug therapy</topic><topic>Diarrhea - microbiology</topic><topic>Diarrhea - prevention & control</topic><topic>Digestive system</topic><topic>Double-Blind Method</topic><topic>Escherichia coli</topic><topic>Escherichia coli Infections - drug therapy</topic><topic>Escherichia coli Infections - prevention & control</topic><topic>Female</topic><topic>Fever</topic><topic>Gastrointestinal Diseases - drug therapy</topic><topic>Gastrointestinal Diseases - microbiology</topic><topic>Gastrointestinal Diseases - prevention & control</topic><topic>Giardia lamblia</topic><topic>Giardiasis - drug therapy</topic><topic>Giardiasis - prevention & control</topic><topic>Humans</topic><topic>Infant</topic><topic>Infections</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mexico - epidemiology</topic><topic>Pathogens</topic><topic>Pharmacology. Drug treatments</topic><topic>Placebos</topic><topic>Prevalence</topic><topic>Regression analysis</topic><topic>Vitamin A</topic><topic>Vitamin A - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Long, Kurt Z.</creatorcontrib><creatorcontrib>Santos, Jose Ignacio</creatorcontrib><creatorcontrib>Rosado, Jorge L.</creatorcontrib><creatorcontrib>Lopez-Saucedo, Catalina</creatorcontrib><creatorcontrib>Thompson-Bonilla, Rocio</creatorcontrib><creatorcontrib>Abonce, Maricela</creatorcontrib><creatorcontrib>DuPont, Herbert L.</creatorcontrib><creatorcontrib>Hertzmark, Ellen</creatorcontrib><creatorcontrib>Estrada-Garcia, Teresa</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Long, Kurt Z.</au><au>Santos, Jose Ignacio</au><au>Rosado, Jorge L.</au><au>Lopez-Saucedo, Catalina</au><au>Thompson-Bonilla, Rocio</au><au>Abonce, Maricela</au><au>DuPont, Herbert L.</au><au>Hertzmark, Ellen</au><au>Estrada-Garcia, Teresa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Vitamin A on Selected Gastrointestinal Pathogen Infections and Associated Diarrheal Episodes among Children in Mexico City, Mexico</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2006-11-01</date><risdate>2006</risdate><volume>194</volume><issue>9</issue><spage>1217</spage><epage>1225</epage><pages>1217-1225</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>BackgroundThe overall effect of vitamin A supplementation on diarrheal disease in community trials may result from its effect on specific diarrheal pathogens MethodsWe conducted a placebo-controlled, double-blind trial of the prophylactic effect of vitamin A on gastrointestinal pathogen infections and clinical symptoms among 188 children in Mexico City, Mexico, from January 1998 to May 1999. Children 6–15 months of age were randomly assigned to receive either a vitamin A supplement (for children <12 months of age, 20,000 international units [IU] of retinol; for children ⩾12 months of age, 45,000 IU of retinol) every 2 months or a placebo and were followed for up to 15 months. Stool samples, collected semimonthly, were screened for enteropathogenic Escherichia coli (EPEC), enterotoxigenic E. coli (ETEC), Shiga toxin–producing E. coli (STEC), enteroinvasive E. coli (EIEC), and Giardia lamblia ResultsVitamin A supplementation reduced the prevalence of EPEC infections (rate ratio [RR], 0.52 [95% confidence interval {CI}, 0.23–0.86]) and led to shorter durations of both EPEC and ETEC infections. Supplementation also reduced the prevalence of EPEC-associated diarrhea (RR, 0.41 [95% CI, 0.16–1.00]), EPEC-associated fever (RR, 0.15 [95% CI, 0.02–0.98]), and G. lamblia–associated fever (RR, 0.27 [95% CI, 0.13–0.80]). Finally, children who received vitamin A supplementation had shorter durations of EPEC-associated diarrhea than did children who did not receive supplementation but had longer durations of G. lamblia–associated diarrhea ConclusionsThese results suggest that the effect of vitamin A supplementation on clinical outcomes may be pathogen dependent</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>17041847</pmid><doi>10.1086/508292</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Bacteria Biological and medical sciences Child nutrition Communities Diarrhea Diarrhea - drug therapy Diarrhea - microbiology Diarrhea - prevention & control Digestive system Double-Blind Method Escherichia coli Escherichia coli Infections - drug therapy Escherichia coli Infections - prevention & control Female Fever Gastrointestinal Diseases - drug therapy Gastrointestinal Diseases - microbiology Gastrointestinal Diseases - prevention & control Giardia lamblia Giardiasis - drug therapy Giardiasis - prevention & control Humans Infant Infections Male Medical sciences Mexico - epidemiology Pathogens Pharmacology. Drug treatments Placebos Prevalence Regression analysis Vitamin A Vitamin A - therapeutic use |
| title | Impact of Vitamin A on Selected Gastrointestinal Pathogen Infections and Associated Diarrheal Episodes among Children in Mexico City, Mexico |
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