DNA methylation in osteoarthritic chondrocytes: a new molecular target

Summary Objective To review the current knowledge of the mechanism of DNA methylation, its association with transcriptional silencing, possible mechanisms of hyper- and hypomethylation and how epigenetic changes may relate to the pathogenesis of osteoarthritis (OA). Methods Journal literature was se...

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Veröffentlicht in:	Osteoarthritis and cartilage 2007-02, Vol.15 (2), p.128-137
Hauptverfasser:	Roach, H.I., Ph.D, Aigner, T., M.D., D.Sc
Format:	Artikel
Sprache:	eng
Schlagworte:	Cartilage articular Chondrocytes - metabolism DNA Methylation Epigenesis, Genetic - genetics Epigenetics Humans Inflammatory cytokines Matrix metalloproteases Osteoarthritis Osteoarthritis - genetics Osteoarthritis - metabolism Rheumatology
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