Molecular mechanisms of cyclosporin a inhibition of the cytokine-induced matrix metalloproteinase-9 in glomerular mesangial cells

The effects of the immunosuppressants cyclosporin A (CsA) and tacrolimus (FK506) on the IL-1beta-induced matrix metalloproteinase-9 (MMP-9) were investigated. Impairment of the protease-antiprotease balance contributes to renal fibrosis, which is observed collectively under long-term treatment with...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2007-02, Vol.18 (2), p.581-592
Hauptverfasser:	DOLLER, Anke, AKOOL, El-Sayed, MÜLLER, Roswitha, GUTWEIN, Paul, KUROWSKI, Christine, PFEILSCHIFTER, Josef, EBERHARDT, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Cyclosporine - pharmacology Cytokines - pharmacology Disease Progression Enzyme Induction Glomerular Mesangium - cytology Glomerular Mesangium - drug effects Glomerular Mesangium - enzymology Humans Immunomodulators Immunosuppressive Agents - pharmacology Interleukin-1beta - pharmacology Kidney Diseases - enzymology Kidney Diseases - physiopathology Matrix Metalloproteinase 9 - biosynthesis Matrix Metalloproteinase Inhibitors Medical sciences Nephrology. Urinary tract diseases Pharmacology. Drug treatments Rats Recombinant Proteins - pharmacology Tacrolimus - pharmacology
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