Upregulation of PBR mRNA expression in human neuroblastoma cells by flavonoids
To investigate the putative mediation of peripheral benzodiazepine receptor (PBR) in the cytotoxicity of flavonoids, in this study, modulatory effects of several flavonoids on the lipid peroxide (LPO) production and PBR mRNA expression of human neuroblastoma cells were observed. Elevated levels of p...
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| Veröffentlicht in: | Phytomedicine (Stuttgart) 2007-02, Vol.14 (2), p.232-235 |
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| creator | Ha, Jeoung-Hee Lee, Jae-Tae Cho, Ihn-ho Chun, Kyung-Ah Park, Gi-Eun Choi, Hyung-Chul Lee, Kwang-Youn Kim, Sang-Hyun Suk, Kyoungho Kim, In-Kyeom Lee, Maan-Gee |
| description | To investigate the putative mediation of peripheral benzodiazepine receptor (PBR) in the cytotoxicity of flavonoids, in this study, modulatory effects of several flavonoids on the lipid peroxide (LPO) production and PBR mRNA expression of human neuroblastoma cells were observed. Elevated levels of peroxidated products in cancer cells may activate pro-apoptotic and anti-proliferative signaling pathways. Treatment of 10
−6
M 4′-chlorodiazepam and PK 11195 ligands of the PBR for 6 days enhanced the generation of LPO of the human neuroblastoma cells. Several flavonoids, well-known cytotoxic substances, potentiated the enhancement of LPO production by PBR ligands. Treatment of 10
−6
M flavonoids for 6 days elevated the expression of PBR mRNA in cells. These findings indicate that the potential of flavonoids to induce apoptosis in cancer cells is strongly associated with their PBR-inducing properties, thereby providing a new mechanism by which polyphenolic compounds may exert their cancer-preventive and anti-neoplastic effects. |
| doi_str_mv | 10.1016/j.phymed.2005.11.004 |
| format | Article |
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−6
M 4′-chlorodiazepam and PK 11195 ligands of the PBR for 6 days enhanced the generation of LPO of the human neuroblastoma cells. Several flavonoids, well-known cytotoxic substances, potentiated the enhancement of LPO production by PBR ligands. Treatment of 10
−6
M flavonoids for 6 days elevated the expression of PBR mRNA in cells. These findings indicate that the potential of flavonoids to induce apoptosis in cancer cells is strongly associated with their PBR-inducing properties, thereby providing a new mechanism by which polyphenolic compounds may exert their cancer-preventive and anti-neoplastic effects.</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/j.phymed.2005.11.004</identifier><identifier>PMID: 16427264</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Antineoplastic Agents, Phytogenic - administration & dosage ; Antineoplastic Agents, Phytogenic - pharmacology ; Antineoplastic Agents, Phytogenic - therapeutic use ; Benzodiazepines ; Benzodiazepinones - agonists ; Benzodiazepinones - metabolism ; Benzodiazepinones - pharmacology ; Bioflavonoids ; Cancer cells ; Cell Line, Tumor - drug effects ; Cytotoxicity ; DNA Primers ; Dosage and administration ; Flavones ; Flavonoids ; Flavonoids - administration & dosage ; Flavonoids - pharmacology ; Flavonoids - therapeutic use ; Genetic aspects ; Humans ; Lipid Peroxides ; Messenger RNA ; Neuroblastoma ; Neuroblastoma - pathology ; Peripheral benzodiazepine receptor (PBR) ; Physiological aspects ; Phytotherapy ; Plants, Medicinal ; Receptors, GABA-A - genetics ; Receptors, GABA-A - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - analysis ; Up-Regulation - drug effects</subject><ispartof>Phytomedicine (Stuttgart), 2007-02, Vol.14 (2), p.232-235</ispartof><rights>2005 Elsevier GmbH</rights><rights>COPYRIGHT 2007 Urban & Fischer Verlag</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c531t-27b7de305ab9dc1358ebb5f77b557ad20d94f6c9c767c7502a8837dc0bd31c953</citedby><cites>FETCH-LOGICAL-c531t-27b7de305ab9dc1358ebb5f77b557ad20d94f6c9c767c7502a8837dc0bd31c953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.phymed.2005.11.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16427264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ha, Jeoung-Hee</creatorcontrib><creatorcontrib>Lee, Jae-Tae</creatorcontrib><creatorcontrib>Cho, Ihn-ho</creatorcontrib><creatorcontrib>Chun, Kyung-Ah</creatorcontrib><creatorcontrib>Park, Gi-Eun</creatorcontrib><creatorcontrib>Choi, Hyung-Chul</creatorcontrib><creatorcontrib>Lee, Kwang-Youn</creatorcontrib><creatorcontrib>Kim, Sang-Hyun</creatorcontrib><creatorcontrib>Suk, Kyoungho</creatorcontrib><creatorcontrib>Kim, In-Kyeom</creatorcontrib><creatorcontrib>Lee, Maan-Gee</creatorcontrib><title>Upregulation of PBR mRNA expression in human neuroblastoma cells by flavonoids</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>To investigate the putative mediation of peripheral benzodiazepine receptor (PBR) in the cytotoxicity of flavonoids, in this study, modulatory effects of several flavonoids on the lipid peroxide (LPO) production and PBR mRNA expression of human neuroblastoma cells were observed. Elevated levels of peroxidated products in cancer cells may activate pro-apoptotic and anti-proliferative signaling pathways. Treatment of 10
−6
M 4′-chlorodiazepam and PK 11195 ligands of the PBR for 6 days enhanced the generation of LPO of the human neuroblastoma cells. Several flavonoids, well-known cytotoxic substances, potentiated the enhancement of LPO production by PBR ligands. Treatment of 10
−6
M flavonoids for 6 days elevated the expression of PBR mRNA in cells. These findings indicate that the potential of flavonoids to induce apoptosis in cancer cells is strongly associated with their PBR-inducing properties, thereby providing a new mechanism by which polyphenolic compounds may exert their cancer-preventive and anti-neoplastic effects.</description><subject>Antineoplastic Agents, Phytogenic - administration & dosage</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Antineoplastic Agents, Phytogenic - therapeutic use</subject><subject>Benzodiazepines</subject><subject>Benzodiazepinones - agonists</subject><subject>Benzodiazepinones - metabolism</subject><subject>Benzodiazepinones - pharmacology</subject><subject>Bioflavonoids</subject><subject>Cancer cells</subject><subject>Cell Line, Tumor - drug effects</subject><subject>Cytotoxicity</subject><subject>DNA Primers</subject><subject>Dosage and administration</subject><subject>Flavones</subject><subject>Flavonoids</subject><subject>Flavonoids - administration & dosage</subject><subject>Flavonoids - pharmacology</subject><subject>Flavonoids - therapeutic use</subject><subject>Genetic aspects</subject><subject>Humans</subject><subject>Lipid Peroxides</subject><subject>Messenger RNA</subject><subject>Neuroblastoma</subject><subject>Neuroblastoma - pathology</subject><subject>Peripheral benzodiazepine receptor (PBR)</subject><subject>Physiological aspects</subject><subject>Phytotherapy</subject><subject>Plants, Medicinal</subject><subject>Receptors, GABA-A - genetics</subject><subject>Receptors, GABA-A - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - analysis</subject><subject>Up-Regulation - drug effects</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV2L1DAUhoMo7rj6D0QCgnetSdsk7Y0wu_gFyyqLC96FfJzOZmiTMWkX59-b0kEQBsnFgXOeN8l5X4ReU1JSQvn7fXl4OI5gy4oQVlJaEtI8QRvKaVuQjv18ijaka5pCUFpfoBcp7QmhTSfIc3RBeVOJijcbdHt_iLCbBzW54HHo8ferOzze3W4x_M6TlJa28_hhHpXHHuYY9KDSFEaFDQxDwvqI-0E9Bh-cTS_Rs14NCV6d6iW6__Txx_WX4ubb56_X25vCsJpORSW0sFATpnRnDa1ZC1qzXgjNmFC2IrZrem46I7gwgpFKtW0trCHa1tR0rL5E79Z7DzH8miFNcnRp-Y_yEOYkedsxLlqSwbcruFMDSOf7MEVlFlhuF6tENo9nqjhD7cBDVEPw0Lvc_ocvz_D5WBidOStoVoGJIaUIvTxEN6p4lJTIJU65l2uccolTUipznFn25rTmrJfZX9Epvwx8WAHIZj86iDIZB96AdRHMJG1w_3_hD4tmsRI</recordid><startdate>200702</startdate><enddate>200702</enddate><creator>Ha, Jeoung-Hee</creator><creator>Lee, Jae-Tae</creator><creator>Cho, Ihn-ho</creator><creator>Chun, Kyung-Ah</creator><creator>Park, Gi-Eun</creator><creator>Choi, Hyung-Chul</creator><creator>Lee, Kwang-Youn</creator><creator>Kim, Sang-Hyun</creator><creator>Suk, Kyoungho</creator><creator>Kim, In-Kyeom</creator><creator>Lee, Maan-Gee</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200702</creationdate><title>Upregulation of PBR mRNA expression in human neuroblastoma cells by flavonoids</title><author>Ha, Jeoung-Hee ; Lee, Jae-Tae ; Cho, Ihn-ho ; Chun, Kyung-Ah ; Park, Gi-Eun ; Choi, Hyung-Chul ; Lee, Kwang-Youn ; Kim, Sang-Hyun ; Suk, Kyoungho ; Kim, In-Kyeom ; Lee, Maan-Gee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c531t-27b7de305ab9dc1358ebb5f77b557ad20d94f6c9c767c7502a8837dc0bd31c953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Antineoplastic Agents, Phytogenic - administration & dosage</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Antineoplastic Agents, Phytogenic - therapeutic use</topic><topic>Benzodiazepines</topic><topic>Benzodiazepinones - agonists</topic><topic>Benzodiazepinones - metabolism</topic><topic>Benzodiazepinones - pharmacology</topic><topic>Bioflavonoids</topic><topic>Cancer cells</topic><topic>Cell Line, Tumor - drug effects</topic><topic>Cytotoxicity</topic><topic>DNA Primers</topic><topic>Dosage and administration</topic><topic>Flavones</topic><topic>Flavonoids</topic><topic>Flavonoids - administration & dosage</topic><topic>Flavonoids - pharmacology</topic><topic>Flavonoids - therapeutic use</topic><topic>Genetic aspects</topic><topic>Humans</topic><topic>Lipid Peroxides</topic><topic>Messenger RNA</topic><topic>Neuroblastoma</topic><topic>Neuroblastoma - pathology</topic><topic>Peripheral benzodiazepine receptor (PBR)</topic><topic>Physiological aspects</topic><topic>Phytotherapy</topic><topic>Plants, Medicinal</topic><topic>Receptors, GABA-A - genetics</topic><topic>Receptors, GABA-A - metabolism</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - analysis</topic><topic>Up-Regulation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ha, Jeoung-Hee</creatorcontrib><creatorcontrib>Lee, Jae-Tae</creatorcontrib><creatorcontrib>Cho, Ihn-ho</creatorcontrib><creatorcontrib>Chun, Kyung-Ah</creatorcontrib><creatorcontrib>Park, Gi-Eun</creatorcontrib><creatorcontrib>Choi, Hyung-Chul</creatorcontrib><creatorcontrib>Lee, Kwang-Youn</creatorcontrib><creatorcontrib>Kim, Sang-Hyun</creatorcontrib><creatorcontrib>Suk, Kyoungho</creatorcontrib><creatorcontrib>Kim, In-Kyeom</creatorcontrib><creatorcontrib>Lee, Maan-Gee</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ha, Jeoung-Hee</au><au>Lee, Jae-Tae</au><au>Cho, Ihn-ho</au><au>Chun, Kyung-Ah</au><au>Park, Gi-Eun</au><au>Choi, Hyung-Chul</au><au>Lee, Kwang-Youn</au><au>Kim, Sang-Hyun</au><au>Suk, Kyoungho</au><au>Kim, In-Kyeom</au><au>Lee, Maan-Gee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Upregulation of PBR mRNA expression in human neuroblastoma cells by flavonoids</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2007-02</date><risdate>2007</risdate><volume>14</volume><issue>2</issue><spage>232</spage><epage>235</epage><pages>232-235</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>To investigate the putative mediation of peripheral benzodiazepine receptor (PBR) in the cytotoxicity of flavonoids, in this study, modulatory effects of several flavonoids on the lipid peroxide (LPO) production and PBR mRNA expression of human neuroblastoma cells were observed. Elevated levels of peroxidated products in cancer cells may activate pro-apoptotic and anti-proliferative signaling pathways. Treatment of 10
−6
M 4′-chlorodiazepam and PK 11195 ligands of the PBR for 6 days enhanced the generation of LPO of the human neuroblastoma cells. Several flavonoids, well-known cytotoxic substances, potentiated the enhancement of LPO production by PBR ligands. Treatment of 10
−6
M flavonoids for 6 days elevated the expression of PBR mRNA in cells. These findings indicate that the potential of flavonoids to induce apoptosis in cancer cells is strongly associated with their PBR-inducing properties, thereby providing a new mechanism by which polyphenolic compounds may exert their cancer-preventive and anti-neoplastic effects.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>16427264</pmid><doi>10.1016/j.phymed.2005.11.004</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-7113 |
| ispartof | Phytomedicine (Stuttgart), 2007-02, Vol.14 (2), p.232-235 |
| issn | 0944-7113 1618-095X |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Benzodiazepines Benzodiazepinones - agonists Benzodiazepinones - metabolism Benzodiazepinones - pharmacology Bioflavonoids Cancer cells Cell Line, Tumor - drug effects Cytotoxicity DNA Primers Dosage and administration Flavones Flavonoids Flavonoids - administration & dosage Flavonoids - pharmacology Flavonoids - therapeutic use Genetic aspects Humans Lipid Peroxides Messenger RNA Neuroblastoma Neuroblastoma - pathology Peripheral benzodiazepine receptor (PBR) Physiological aspects Phytotherapy Plants, Medicinal Receptors, GABA-A - genetics Receptors, GABA-A - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Up-Regulation - drug effects |
| title | Upregulation of PBR mRNA expression in human neuroblastoma cells by flavonoids |
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