The Role of the C-terminal Domain of Protein Tyrosine Phosphatase-1B in Phosphatase Activity and Substrate Binding

Protein tyrosine phosphatase 1B (PTP-1B) has been implicated in the regulation of the insulin receptor. Dephosphorylation of the insulin receptor results in decreased insulin signaling and thus decreased glucose uptake. PTP-1B–/– mice have increased insulin sensitivity and are resistant to weight ga...

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Veröffentlicht in:	The Journal of biological chemistry 2007-02, Vol.282 (5), p.2911-2917
Hauptverfasser:	Picha, Kristen M., Patel, Smita S., Mandiyan, Sreekala, Koehn, James, Wennogle, Lawrence P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites DNA Primers Humans Kinetics Peptide Fragments - chemistry Peptide Fragments - metabolism Phosphopeptides - chemistry Phosphopeptides - metabolism Phosphorylation Polymerase Chain Reaction Protein Tyrosine Phosphatases - chemistry Protein Tyrosine Phosphatases - genetics Protein Tyrosine Phosphatases - metabolism Recombinant Proteins - metabolism
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