Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex
Genes at the centromeric end of the human leukocyte antigen region influence adaptive autoimmune diseases and cancer. In this study, we characterized protein expression of HKE2, a gene located in the centromeric portion of the class II region of the major histocompatibility complex encoding subunit...
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| Veröffentlicht in: | Tissue antigens 2007-02, Vol.69 (2), p.181-188 |
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| container_title | Tissue antigens |
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| creator | Ostrov, D. A. Barnes, C. L. Smith, L. E. Binns, S. Brusko, T. M. Brown, A. C. Quint, P. S. Litherland, S. A. Roopenian, D. C. Iczkowski, K. A. |
| description | Genes at the centromeric end of the human leukocyte antigen region influence adaptive autoimmune diseases and cancer. In this study, we characterized protein expression of HKE2, a gene located in the centromeric portion of the class II region of the major histocompatibility complex encoding subunit 6 of prefoldin. Immunohistochemical analysis using an anti‐HKE2 antibody indicated that HKE2 protein expression is dramatically upregulated as a consequence of activation. In a tissue microarray and in several tumors, HKE2 was overexpressed in certain cancers compared with normal counterparts. The localization of the HKE2 gene to the class II region, its cytoplasmic expression and putative protein‐binding domain suggest that HKE2 may function in adaptive immunity and cancer. |
| doi_str_mv | 10.1111/j.1399-0039.2006.00730.x |
| format | Article |
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A. ; Barnes, C. L. ; Smith, L. E. ; Binns, S. ; Brusko, T. M. ; Brown, A. C. ; Quint, P. S. ; Litherland, S. A. ; Roopenian, D. C. ; Iczkowski, K. A.</creator><creatorcontrib>Ostrov, D. A. ; Barnes, C. L. ; Smith, L. E. ; Binns, S. ; Brusko, T. M. ; Brown, A. C. ; Quint, P. S. ; Litherland, S. A. ; Roopenian, D. C. ; Iczkowski, K. A.</creatorcontrib><description>Genes at the centromeric end of the human leukocyte antigen region influence adaptive autoimmune diseases and cancer. In this study, we characterized protein expression of HKE2, a gene located in the centromeric portion of the class II region of the major histocompatibility complex encoding subunit 6 of prefoldin. Immunohistochemical analysis using an anti‐HKE2 antibody indicated that HKE2 protein expression is dramatically upregulated as a consequence of activation. In a tissue microarray and in several tumors, HKE2 was overexpressed in certain cancers compared with normal counterparts. 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A.</creatorcontrib><creatorcontrib>Barnes, C. L.</creatorcontrib><creatorcontrib>Smith, L. E.</creatorcontrib><creatorcontrib>Binns, S.</creatorcontrib><creatorcontrib>Brusko, T. M.</creatorcontrib><creatorcontrib>Brown, A. C.</creatorcontrib><creatorcontrib>Quint, P. S.</creatorcontrib><creatorcontrib>Litherland, S. A.</creatorcontrib><creatorcontrib>Roopenian, D. C.</creatorcontrib><creatorcontrib>Iczkowski, K. A.</creatorcontrib><title>Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex</title><title>Tissue antigens</title><addtitle>Tissue Antigens</addtitle><description>Genes at the centromeric end of the human leukocyte antigen region influence adaptive autoimmune diseases and cancer. In this study, we characterized protein expression of HKE2, a gene located in the centromeric portion of the class II region of the major histocompatibility complex encoding subunit 6 of prefoldin. Immunohistochemical analysis using an anti‐HKE2 antibody indicated that HKE2 protein expression is dramatically upregulated as a consequence of activation. In a tissue microarray and in several tumors, HKE2 was overexpressed in certain cancers compared with normal counterparts. The localization of the HKE2 gene to the class II region, its cytoplasmic expression and putative protein‐binding domain suggest that HKE2 may function in adaptive immunity and cancer.</description><subject>Amino Acid Sequence</subject><subject>antigen processing</subject><subject>Binding Sites</subject><subject>Chromosome Mapping</subject><subject>class II MHC</subject><subject>Cytoplasm - chemistry</subject><subject>disease candidate gene</subject><subject>expressed sequence tag</subject><subject>Genes, MHC Class II - genetics</subject><subject>Hematopoietic Stem Cells - chemistry</subject><subject>Hematopoietic Stem Cells - metabolism</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Molecular Chaperones - analysis</subject><subject>Molecular Chaperones - genetics</subject><subject>Molecular Chaperones - metabolism</subject><subject>Molecular Sequence Data</subject><subject>Neoplasms - chemistry</subject><subject>Neoplasms - metabolism</subject><subject>Protein Conformation</subject><subject>Tumor Cells, Cultured</subject><issn>0001-2815</issn><issn>1399-0039</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV-P1CAUxYnRuOPqVzA8-dZ6gRaK8WWd7B-z67qJa3wxIZTeOoxtGUsnzvjppc5kfVRCcrnh_C7hHEIog5yl9XqdM6F1BiB0zgFkDqAE5LtHZPFw8ZgsAIBlvGLlCXkW4zp1hdL6KTlhipdKcL4gX5crO1o34eh_2cmHgYaWXl2f8zfUDmk7j8OU6uS_4UBxcKHBhvqBTiukvV2Hka58nIIL_Sbxte_8tKdz1-HuOXnS2i7ii2M9JZ8vzu-XV9nNx8v3y7ObzBWihIxr0FXDG8S2lTXTpeQO6koWlZBFwbljTjLrlLaiaFmrFEINvOK2YTUTqhan5NVh7mYMP7YYJ9P76LDr7IBhG42sdJl-XvxTyKGQUDKRhNVB6MYQ44it2Yy-t-PeMDBzBGZtZqfN7LSZIzB_IjC7hL48vrGte2z-gkfPk-DtQfDTd7j_78Hm_uw2HRKeHfBkO-4ecDt-N1IJVZovt5fmw7vy7hO_uDZ34jdNWaM6</recordid><startdate>200702</startdate><enddate>200702</enddate><creator>Ostrov, D. 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| subjects | Amino Acid Sequence antigen processing Binding Sites Chromosome Mapping class II MHC Cytoplasm - chemistry disease candidate gene expressed sequence tag Genes, MHC Class II - genetics Hematopoietic Stem Cells - chemistry Hematopoietic Stem Cells - metabolism Humans Immunohistochemistry Molecular Chaperones - analysis Molecular Chaperones - genetics Molecular Chaperones - metabolism Molecular Sequence Data Neoplasms - chemistry Neoplasms - metabolism Protein Conformation Tumor Cells, Cultured |
| title | Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex |
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