Assembly of trans-encapsidated recombinant viral vectors engineered from Tobacco mosaic virus and Semliki Forest virus and their evaluation as immunogens

Abstract RNA virus vectors are attractive vaccine delivery agents capable of directing high-level gene expression without integration into host cell DNA. However, delivery of non-encapsidated RNA viral vectors into animal cells is relatively inefficient. By introducing the tobacco mosaic virus (TMV)...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2007-02, Vol.358 (2), p.321-333
Hauptverfasser:	Smith, Mark L, Corbo, Tina, Bernales, Jacqueline, Lindbo, John A, Pogue, Gregory P, Palmer, Kenneth E, McCormick, Alison A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alphavirus Animals Antibodies, Viral - blood Antibody response antigens beta-Galactosidase - immunology beta-Galactosidase - metabolism Capsid Proteins - metabolism Cellular immune response Female genetic recombination genetic vectors Genetic Vectors - metabolism Immunization Immunization Schedule Infectious Disease Injections, Subcutaneous Lymphocyte Activation Mice Mice, Inbred C57BL plant viruses Pseudovirus Reassembly RNA, Viral - metabolism Semliki Forest virus Semliki forest virus - genetics Semliki forest virus - metabolism Spleen - immunology T-Lymphocytes - immunology Tobacco mosaic virus Tobacco Mosaic Virus - genetics Tobacco Mosaic Virus - physiology Viral Proteins - immunology Viral Proteins - metabolism Viral Vaccines - administration & dosage Viral Vaccines - immunology virion virus assembly Virus Replication
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