Determination of tropisetron in human plasma by high performance liquid chromatographic method with UV detection and its application to a bioequivalence study
A simple and sensitive high performance liquid chromatography method with UV detection was described for the determination of tropisetron in human plasma. The prepared sample solution was injected onto BDS-C 8 reversed column using a mixture of ammonium acetate (100 mM, PH adjusted to 4.3 with glaci...
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| Veröffentlicht in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2007-02, Vol.846 (1), p.20-23 |
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| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
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| creator | Yu, Li Bao, Ludan Guo, Yunzhen Guo, Xingjie |
| description | A simple and sensitive high performance liquid chromatography method with UV detection was described for the determination of tropisetron in human plasma. The prepared sample solution was injected onto BDS-C
8 reversed column using a mixture of ammonium acetate (100
mM, PH adjusted to 4.3 with glacial acetic acid) and acetonitrile (80:20, v/v) as mobile phase. The wavelength of UV detector was set at 285
nm. No interference from any endogenous substances was observed during the elution of tropisetron and internal standard (ondansetron hydrochloride). The lower limit of quantification was evaluated to be 1
ng/mL. The method was used in a randomized crossover bioequivalence study of two different tropisetron preparations in 20 healthy volunteers. |
| doi_str_mv | 10.1016/j.jchromb.2006.08.023 |
| format | Article |
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8 reversed column using a mixture of ammonium acetate (100
mM, PH adjusted to 4.3 with glacial acetic acid) and acetonitrile (80:20, v/v) as mobile phase. The wavelength of UV detector was set at 285
nm. No interference from any endogenous substances was observed during the elution of tropisetron and internal standard (ondansetron hydrochloride). The lower limit of quantification was evaluated to be 1
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8 reversed column using a mixture of ammonium acetate (100
mM, PH adjusted to 4.3 with glacial acetic acid) and acetonitrile (80:20, v/v) as mobile phase. The wavelength of UV detector was set at 285
nm. No interference from any endogenous substances was observed during the elution of tropisetron and internal standard (ondansetron hydrochloride). The lower limit of quantification was evaluated to be 1
ng/mL. The method was used in a randomized crossover bioequivalence study of two different tropisetron preparations in 20 healthy volunteers.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Bioequivalence study</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>High performance liquid chromatography</subject><subject>Humans</subject><subject>Indoles - blood</subject><subject>Indoles - pharmacokinetics</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Spectrophotometry, Ultraviolet - methods</subject><subject>Therapeutic Equivalency</subject><subject>Tropisetron</subject><subject>UV detection</subject><issn>1570-0232</issn><issn>1873-376X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQhSNERX_gEUDewC6pnR_bWSFUKCBV6qZF7CzHnjRzlcSp7RTdl-FZ8e2N1CUrW_Y354zOybL3jBaMMn65K3Zm8G7qipJSXlBZ0LJ6lZ0xKaq8Evz363RvBM3Tc3manYewo5QJKqo32SnjLS-rlp5lf79CBD_hrCO6mbieRO8WDJCOmeBMhnXSM1lGHSZNuj0Z8GEgC_je-fRhgIz4uKIlz8vo6B68XgY0ZII4OEv-YBzI_S9ik415ttCzJRgD0csyojnaRkeSODpIUk96hINuiKvdv81Oej0GeLedF9n99be7qx_5ze33n1dfbnJTl2XMu6bpRG-gg97QhrVdSYXpdcmFZdBKbjRQU0uhLW8roSXvq6bqgNW8BlmytrrIPh11F-8eVwhRTRgMjKOewa1Bcdk2aUQksDmCxrsQPPRq8Thpv1eMqkMxaqe2YtShGEWlSg2kuQ-bwdpNYF-mtiYS8HEDdDB67H0KF8MLJ2vZ0rpO3OcjBymOJwSvgsFDYBZ9SlhZh_9Z5R8pw7OB</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>Yu, Li</creator><creator>Bao, Ludan</creator><creator>Guo, Yunzhen</creator><creator>Guo, Xingjie</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070201</creationdate><title>Determination of tropisetron in human plasma by high performance liquid chromatographic method with UV detection and its application to a bioequivalence study</title><author>Yu, Li ; Bao, Ludan ; Guo, Yunzhen ; Guo, Xingjie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-b55b7fcebefc0519b207cfa267d1e986cae0c487ad6937a86f353be1464e82193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Bioequivalence study</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>High performance liquid chromatography</topic><topic>Humans</topic><topic>Indoles - blood</topic><topic>Indoles - pharmacokinetics</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Spectrophotometry, Ultraviolet - methods</topic><topic>Therapeutic Equivalency</topic><topic>Tropisetron</topic><topic>UV detection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Li</creatorcontrib><creatorcontrib>Bao, Ludan</creatorcontrib><creatorcontrib>Guo, Yunzhen</creatorcontrib><creatorcontrib>Guo, Xingjie</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chromatography. 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B, Analytical technologies in the biomedical and life sciences</jtitle><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><date>2007-02-01</date><risdate>2007</risdate><volume>846</volume><issue>1</issue><spage>20</spage><epage>23</epage><pages>20-23</pages><issn>1570-0232</issn><eissn>1873-376X</eissn><abstract>A simple and sensitive high performance liquid chromatography method with UV detection was described for the determination of tropisetron in human plasma. The prepared sample solution was injected onto BDS-C
8 reversed column using a mixture of ammonium acetate (100
mM, PH adjusted to 4.3 with glacial acetic acid) and acetonitrile (80:20, v/v) as mobile phase. The wavelength of UV detector was set at 285
nm. No interference from any endogenous substances was observed during the elution of tropisetron and internal standard (ondansetron hydrochloride). The lower limit of quantification was evaluated to be 1
ng/mL. The method was used in a randomized crossover bioequivalence study of two different tropisetron preparations in 20 healthy volunteers.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>16962390</pmid><doi>10.1016/j.jchromb.2006.08.023</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 1570-0232 |
| ispartof | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007-02, Vol.846 (1), p.20-23 |
| issn | 1570-0232 1873-376X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analysis Analytical, structural and metabolic biochemistry Bioequivalence study Biological and medical sciences Chromatography, High Pressure Liquid - methods Fundamental and applied biological sciences. Psychology General pharmacology High performance liquid chromatography Humans Indoles - blood Indoles - pharmacokinetics Medical sciences Pharmacology. Drug treatments Reproducibility of Results Sensitivity and Specificity Spectrophotometry, Ultraviolet - methods Therapeutic Equivalency Tropisetron UV detection |
| title | Determination of tropisetron in human plasma by high performance liquid chromatographic method with UV detection and its application to a bioequivalence study |
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