Roles of Aurora kinases in mitosis and tumorigenesis

Aurora kinases, which have been implicated in several vital events in mitosis, represent a protein kinase family highly conserved during evolution. The activity of Aurora kinases is delicately regulated, mainly by phosphorylation and degradation. Deregulation of Aurora kinase activity can result in...

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Veröffentlicht in:	Molecular cancer research 2007-01, Vol.5 (1), p.1-10
Hauptverfasser:	Fu, Jingyan, Bian, Minglei, Jiang, Qing, Zhang, Chuanmao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aurora Kinases Cell Division Chromosome Segregation - genetics Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Humans Mitosis - physiology Models, Biological Neoplasms - enzymology Neoplasms - pathology Protein-Serine-Threonine Kinases - physiology
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