Roles of Aurora kinases in mitosis and tumorigenesis
Aurora kinases, which have been implicated in several vital events in mitosis, represent a protein kinase family highly conserved during evolution. The activity of Aurora kinases is delicately regulated, mainly by phosphorylation and degradation. Deregulation of Aurora kinase activity can result in...
Gespeichert in:
| Veröffentlicht in: | Molecular cancer research 2007-01, Vol.5 (1), p.1-10 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 10 |
|---|---|
| container_issue | 1 |
| container_start_page | 1 |
| container_title | Molecular cancer research |
| container_volume | 5 |
| creator | Fu, Jingyan Bian, Minglei Jiang, Qing Zhang, Chuanmao |
| description | Aurora kinases, which have been implicated in several vital events in mitosis, represent a protein kinase family highly conserved during evolution. The activity of Aurora kinases is delicately regulated, mainly by phosphorylation and degradation. Deregulation of Aurora kinase activity can result in mitotic abnormality and genetic instability, leading to defects in centrosome function, spindle assembly, chromosome alignment, and cytokinesis. Both the expression level and the kinase activity of Aurora kinases are found to be up-regulated in many human cancers, indicating that these kinases might serve as useful targets for the development of anticancer drugs. This review focuses on recent progress on the roles of Aurora kinases in mitosis and tumorigenesis. |
| doi_str_mv | 10.1158/1541-7786.mcr-06-0208 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68953060</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20798875</sourcerecordid><originalsourceid>FETCH-LOGICAL-c404t-921cb6d720d84ae92203c189f6715fabf3dd95dc34f86e5b42da8d6ab06d86573</originalsourceid><addsrcrecordid>eNqFkMtKxDAUhoMozjj6CEpX7jrmnnQ5DN5gRBh0HdJcJNo2Y9IufHtbpuDS1Tn8fP858AFwjeAaISbvEKOoFELydWtSCXkJMZQnYIkYEyVBmJ1O-8wswEXOn3BEkODnYIEEZhWheAnoPjYuF9EXmyHFpIuv0Ok8JqEr2tDHHHKhO1v0QxtT-HCdG5NLcOZ1k93VPFfg_eH-bftU7l4fn7ebXWkopH1ZYWRqbgWGVlLtKowhMUhWngvEvK49sbZi1hDqJXespthqabmuIbeSM0FW4PZ495Di9-Byr9qQjWsa3bk4ZMVlxQjk8F8QQ1FJKdgIsiNoUsw5Oa8OKbQ6_SgE1eRVTc7U5Ey9bPcKcjV5HXs384Ohbp39a80iyS8Y7XNV</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20798875</pqid></control><display><type>article</type><title>Roles of Aurora kinases in mitosis and tumorigenesis</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Fu, Jingyan ; Bian, Minglei ; Jiang, Qing ; Zhang, Chuanmao</creator><creatorcontrib>Fu, Jingyan ; Bian, Minglei ; Jiang, Qing ; Zhang, Chuanmao</creatorcontrib><description>Aurora kinases, which have been implicated in several vital events in mitosis, represent a protein kinase family highly conserved during evolution. The activity of Aurora kinases is delicately regulated, mainly by phosphorylation and degradation. Deregulation of Aurora kinase activity can result in mitotic abnormality and genetic instability, leading to defects in centrosome function, spindle assembly, chromosome alignment, and cytokinesis. Both the expression level and the kinase activity of Aurora kinases are found to be up-regulated in many human cancers, indicating that these kinases might serve as useful targets for the development of anticancer drugs. This review focuses on recent progress on the roles of Aurora kinases in mitosis and tumorigenesis.</description><identifier>ISSN: 1541-7786</identifier><identifier>EISSN: 1557-3125</identifier><identifier>DOI: 10.1158/1541-7786.mcr-06-0208</identifier><identifier>PMID: 17259342</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Aurora Kinases ; Cell Division ; Chromosome Segregation - genetics ; Gene Expression Regulation, Neoplastic ; Genetic Predisposition to Disease ; Humans ; Mitosis - physiology ; Models, Biological ; Neoplasms - enzymology ; Neoplasms - pathology ; Protein-Serine-Threonine Kinases - physiology</subject><ispartof>Molecular cancer research, 2007-01, Vol.5 (1), p.1-10</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-921cb6d720d84ae92203c189f6715fabf3dd95dc34f86e5b42da8d6ab06d86573</citedby><cites>FETCH-LOGICAL-c404t-921cb6d720d84ae92203c189f6715fabf3dd95dc34f86e5b42da8d6ab06d86573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17259342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fu, Jingyan</creatorcontrib><creatorcontrib>Bian, Minglei</creatorcontrib><creatorcontrib>Jiang, Qing</creatorcontrib><creatorcontrib>Zhang, Chuanmao</creatorcontrib><title>Roles of Aurora kinases in mitosis and tumorigenesis</title><title>Molecular cancer research</title><addtitle>Mol Cancer Res</addtitle><description>Aurora kinases, which have been implicated in several vital events in mitosis, represent a protein kinase family highly conserved during evolution. The activity of Aurora kinases is delicately regulated, mainly by phosphorylation and degradation. Deregulation of Aurora kinase activity can result in mitotic abnormality and genetic instability, leading to defects in centrosome function, spindle assembly, chromosome alignment, and cytokinesis. Both the expression level and the kinase activity of Aurora kinases are found to be up-regulated in many human cancers, indicating that these kinases might serve as useful targets for the development of anticancer drugs. This review focuses on recent progress on the roles of Aurora kinases in mitosis and tumorigenesis.</description><subject>Animals</subject><subject>Aurora Kinases</subject><subject>Cell Division</subject><subject>Chromosome Segregation - genetics</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Mitosis - physiology</subject><subject>Models, Biological</subject><subject>Neoplasms - enzymology</subject><subject>Neoplasms - pathology</subject><subject>Protein-Serine-Threonine Kinases - physiology</subject><issn>1541-7786</issn><issn>1557-3125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMozjj6CEpX7jrmnnQ5DN5gRBh0HdJcJNo2Y9IufHtbpuDS1Tn8fP858AFwjeAaISbvEKOoFELydWtSCXkJMZQnYIkYEyVBmJ1O-8wswEXOn3BEkODnYIEEZhWheAnoPjYuF9EXmyHFpIuv0Ok8JqEr2tDHHHKhO1v0QxtT-HCdG5NLcOZ1k93VPFfg_eH-bftU7l4fn7ebXWkopH1ZYWRqbgWGVlLtKowhMUhWngvEvK49sbZi1hDqJXespthqabmuIbeSM0FW4PZ495Di9-Byr9qQjWsa3bk4ZMVlxQjk8F8QQ1FJKdgIsiNoUsw5Oa8OKbQ6_SgE1eRVTc7U5Ey9bPcKcjV5HXs384Ohbp39a80iyS8Y7XNV</recordid><startdate>200701</startdate><enddate>200701</enddate><creator>Fu, Jingyan</creator><creator>Bian, Minglei</creator><creator>Jiang, Qing</creator><creator>Zhang, Chuanmao</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200701</creationdate><title>Roles of Aurora kinases in mitosis and tumorigenesis</title><author>Fu, Jingyan ; Bian, Minglei ; Jiang, Qing ; Zhang, Chuanmao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-921cb6d720d84ae92203c189f6715fabf3dd95dc34f86e5b42da8d6ab06d86573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Aurora Kinases</topic><topic>Cell Division</topic><topic>Chromosome Segregation - genetics</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Mitosis - physiology</topic><topic>Models, Biological</topic><topic>Neoplasms - enzymology</topic><topic>Neoplasms - pathology</topic><topic>Protein-Serine-Threonine Kinases - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fu, Jingyan</creatorcontrib><creatorcontrib>Bian, Minglei</creatorcontrib><creatorcontrib>Jiang, Qing</creatorcontrib><creatorcontrib>Zhang, Chuanmao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Jingyan</au><au>Bian, Minglei</au><au>Jiang, Qing</au><au>Zhang, Chuanmao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Roles of Aurora kinases in mitosis and tumorigenesis</atitle><jtitle>Molecular cancer research</jtitle><addtitle>Mol Cancer Res</addtitle><date>2007-01</date><risdate>2007</risdate><volume>5</volume><issue>1</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>1541-7786</issn><eissn>1557-3125</eissn><abstract>Aurora kinases, which have been implicated in several vital events in mitosis, represent a protein kinase family highly conserved during evolution. The activity of Aurora kinases is delicately regulated, mainly by phosphorylation and degradation. Deregulation of Aurora kinase activity can result in mitotic abnormality and genetic instability, leading to defects in centrosome function, spindle assembly, chromosome alignment, and cytokinesis. Both the expression level and the kinase activity of Aurora kinases are found to be up-regulated in many human cancers, indicating that these kinases might serve as useful targets for the development of anticancer drugs. This review focuses on recent progress on the roles of Aurora kinases in mitosis and tumorigenesis.</abstract><cop>United States</cop><pmid>17259342</pmid><doi>10.1158/1541-7786.mcr-06-0208</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1541-7786 |
| ispartof | Molecular cancer research, 2007-01, Vol.5 (1), p.1-10 |
| issn | 1541-7786 1557-3125 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68953060 |
| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Aurora Kinases Cell Division Chromosome Segregation - genetics Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Humans Mitosis - physiology Models, Biological Neoplasms - enzymology Neoplasms - pathology Protein-Serine-Threonine Kinases - physiology |
| title | Roles of Aurora kinases in mitosis and tumorigenesis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T01%3A05%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Roles%20of%20Aurora%20kinases%20in%20mitosis%20and%20tumorigenesis&rft.jtitle=Molecular%20cancer%20research&rft.au=Fu,%20Jingyan&rft.date=2007-01&rft.volume=5&rft.issue=1&rft.spage=1&rft.epage=10&rft.pages=1-10&rft.issn=1541-7786&rft.eissn=1557-3125&rft_id=info:doi/10.1158/1541-7786.mcr-06-0208&rft_dat=%3Cproquest_cross%3E20798875%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20798875&rft_id=info:pmid/17259342&rfr_iscdi=true |