$Refractive Defects and Cataracts in Mice Lacking Lens Intrinsic Membrane Protein-2$

Refractive Defects and Cataracts in Mice Lacking Lens Intrinsic Membrane Protein-2

To characterize the optical properties of lenses from mice deficient in the gene for lens intrinsic membrane protein-2 (Lim2), which encodes the second most abundant integral protein (Lim2) of lens fiber cell plasma membranes. Lim2-deficient mice were derived from a library of gene-trap embryo stem...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2007-02, Vol.48 (2), p.500-508
Hauptverfasser:	Shiels, Alan, King, Jennifer M, Mackay, Donna S, Bassnett, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences Blotting, Northern Cataract - genetics Cataract - pathology Eye and associated structures. Visual pathways and centers. Vision Eye Proteins - genetics Female Fundamental and applied biological sciences. Psychology Gene Silencing - physiology Genotype Lens diseases Lens, Crystalline - pathology Male Medical sciences Membrane Glycoproteins - genetics Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Confocal Molecular Sequence Data Ophthalmology Phenotype Refractive Errors - genetics Refractive Errors - pathology Reverse Transcriptase Polymerase Chain Reaction Vertebrates: nervous system and sense organs
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