Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat
Obestatin is a recently discovered 23 amino acids peptide derived from the ghrelin gene. As opposed to ghrelin, obestatin was shown to inhibit food intake in mice. The aims of this research were to study the effects of acute obestatin treatment on feeding behavior in the rat and its effects on GH an...
Gespeichert in:
| Veröffentlicht in: | Journal of endocrinological investigation 2006-09, Vol.29 (8), p.RC16-RC18 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | RC18 |
|---|---|
| container_issue | 8 |
| container_start_page | RC16 |
| container_title | Journal of endocrinological investigation |
| container_volume | 29 |
| creator | Bresciani, E Rapetti, D Donà, F Bulgarelli, I Tamiazzo, L Locatelli, V Torsello, A |
| description | Obestatin is a recently discovered 23 amino acids peptide derived from the ghrelin gene. As opposed to ghrelin, obestatin was shown to inhibit food intake in mice. The aims of this research were to study the effects of acute obestatin treatment on feeding behavior in the rat and its effects on GH and corticosterone secretion. Our results demonstrate that in young-adult male rats, obestatin effectively blunts the hunger caused by short-term starvation. Obestatin did not modify GH secretion in 10-day-old rats and did not antagonize the GH-releasing effects of hexarelin. Moreover, obestatin administration had no effects on spontaneous corticosterone secretion. In conclusion, these data demonstrate that in young-adult male rats the newly discovered obestatin can inhibit feeding but does not modify GH and corticosterone release in infant rats. |
| doi_str_mv | 10.1007/BF03344175 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68950357</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68950357</sourcerecordid><originalsourceid>FETCH-LOGICAL-c285t-17c2102c6298bfc0d070c9e81db94b4a17e400eb591327bbf697560f814230783</originalsourceid><addsrcrecordid>eNpFkDFPwzAQRi0EoqWw8AOQJwakwNlOYmeEirZIlbrAxBDZzoUapTHYzsC_J1Urdbrl3ZO-R8gtg0cGIJ9eFiBEnjNZnJEpkxwyJVR5TqYgKpblUMkJuYrxG0BIoeQlmTA5fvAin5LPjcGYdHI9df3WGZcibREb139RMyTaeIy094nufDN0OiFdrqjuG2p9SM76mDD4HmlEGzA5v9fQtEUadLomF63uIt4c74x8LF7f56tsvVm-zZ_XmeWqSBmTljPgtuSVMq2FBiTYChVrTJWbXDOJOQCaomKCS2PaspJFCa1iORcglZiR-4P3J_jfYZxT71y02HW6Rz_EulRVAaKQI_hwAG3wMQZs65_gdjr81Qzqfcr6lHKE747WweywOaHHduIfLV5tVA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68950357</pqid></control><display><type>article</type><title>Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Bresciani, E ; Rapetti, D ; Donà, F ; Bulgarelli, I ; Tamiazzo, L ; Locatelli, V ; Torsello, A</creator><creatorcontrib>Bresciani, E ; Rapetti, D ; Donà, F ; Bulgarelli, I ; Tamiazzo, L ; Locatelli, V ; Torsello, A</creatorcontrib><description>Obestatin is a recently discovered 23 amino acids peptide derived from the ghrelin gene. As opposed to ghrelin, obestatin was shown to inhibit food intake in mice. The aims of this research were to study the effects of acute obestatin treatment on feeding behavior in the rat and its effects on GH and corticosterone secretion. Our results demonstrate that in young-adult male rats, obestatin effectively blunts the hunger caused by short-term starvation. Obestatin did not modify GH secretion in 10-day-old rats and did not antagonize the GH-releasing effects of hexarelin. Moreover, obestatin administration had no effects on spontaneous corticosterone secretion. In conclusion, these data demonstrate that in young-adult male rats the newly discovered obestatin can inhibit feeding but does not modify GH and corticosterone release in infant rats.</description><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/BF03344175</identifier><identifier>PMID: 17033254</identifier><language>eng</language><publisher>Italy</publisher><subject>Animals ; Animals, Newborn ; Corticosterone - blood ; Corticosterone - secretion ; Eating - drug effects ; Eating - physiology ; Feeding Behavior - drug effects ; Feeding Behavior - physiology ; Growth Hormone - blood ; Growth Hormone - secretion ; Male ; Oligopeptides - pharmacology ; Peptide Hormones - pharmacology ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Journal of endocrinological investigation, 2006-09, Vol.29 (8), p.RC16-RC18</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c285t-17c2102c6298bfc0d070c9e81db94b4a17e400eb591327bbf697560f814230783</citedby><cites>FETCH-LOGICAL-c285t-17c2102c6298bfc0d070c9e81db94b4a17e400eb591327bbf697560f814230783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17033254$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bresciani, E</creatorcontrib><creatorcontrib>Rapetti, D</creatorcontrib><creatorcontrib>Donà, F</creatorcontrib><creatorcontrib>Bulgarelli, I</creatorcontrib><creatorcontrib>Tamiazzo, L</creatorcontrib><creatorcontrib>Locatelli, V</creatorcontrib><creatorcontrib>Torsello, A</creatorcontrib><title>Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><description>Obestatin is a recently discovered 23 amino acids peptide derived from the ghrelin gene. As opposed to ghrelin, obestatin was shown to inhibit food intake in mice. The aims of this research were to study the effects of acute obestatin treatment on feeding behavior in the rat and its effects on GH and corticosterone secretion. Our results demonstrate that in young-adult male rats, obestatin effectively blunts the hunger caused by short-term starvation. Obestatin did not modify GH secretion in 10-day-old rats and did not antagonize the GH-releasing effects of hexarelin. Moreover, obestatin administration had no effects on spontaneous corticosterone secretion. In conclusion, these data demonstrate that in young-adult male rats the newly discovered obestatin can inhibit feeding but does not modify GH and corticosterone release in infant rats.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Corticosterone - blood</subject><subject>Corticosterone - secretion</subject><subject>Eating - drug effects</subject><subject>Eating - physiology</subject><subject>Feeding Behavior - drug effects</subject><subject>Feeding Behavior - physiology</subject><subject>Growth Hormone - blood</subject><subject>Growth Hormone - secretion</subject><subject>Male</subject><subject>Oligopeptides - pharmacology</subject><subject>Peptide Hormones - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkDFPwzAQRi0EoqWw8AOQJwakwNlOYmeEirZIlbrAxBDZzoUapTHYzsC_J1Urdbrl3ZO-R8gtg0cGIJ9eFiBEnjNZnJEpkxwyJVR5TqYgKpblUMkJuYrxG0BIoeQlmTA5fvAin5LPjcGYdHI9df3WGZcibREb139RMyTaeIy094nufDN0OiFdrqjuG2p9SM76mDD4HmlEGzA5v9fQtEUadLomF63uIt4c74x8LF7f56tsvVm-zZ_XmeWqSBmTljPgtuSVMq2FBiTYChVrTJWbXDOJOQCaomKCS2PaspJFCa1iORcglZiR-4P3J_jfYZxT71y02HW6Rz_EulRVAaKQI_hwAG3wMQZs65_gdjr81Qzqfcr6lHKE747WweywOaHHduIfLV5tVA</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Bresciani, E</creator><creator>Rapetti, D</creator><creator>Donà, F</creator><creator>Bulgarelli, I</creator><creator>Tamiazzo, L</creator><creator>Locatelli, V</creator><creator>Torsello, A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat</title><author>Bresciani, E ; Rapetti, D ; Donà, F ; Bulgarelli, I ; Tamiazzo, L ; Locatelli, V ; Torsello, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c285t-17c2102c6298bfc0d070c9e81db94b4a17e400eb591327bbf697560f814230783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Corticosterone - blood</topic><topic>Corticosterone - secretion</topic><topic>Eating - drug effects</topic><topic>Eating - physiology</topic><topic>Feeding Behavior - drug effects</topic><topic>Feeding Behavior - physiology</topic><topic>Growth Hormone - blood</topic><topic>Growth Hormone - secretion</topic><topic>Male</topic><topic>Oligopeptides - pharmacology</topic><topic>Peptide Hormones - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bresciani, E</creatorcontrib><creatorcontrib>Rapetti, D</creatorcontrib><creatorcontrib>Donà, F</creatorcontrib><creatorcontrib>Bulgarelli, I</creatorcontrib><creatorcontrib>Tamiazzo, L</creatorcontrib><creatorcontrib>Locatelli, V</creatorcontrib><creatorcontrib>Torsello, A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bresciani, E</au><au>Rapetti, D</au><au>Donà, F</au><au>Bulgarelli, I</au><au>Tamiazzo, L</au><au>Locatelli, V</au><au>Torsello, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat</atitle><jtitle>Journal of endocrinological investigation</jtitle><addtitle>J Endocrinol Invest</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>29</volume><issue>8</issue><spage>RC16</spage><epage>RC18</epage><pages>RC16-RC18</pages><issn>0391-4097</issn><eissn>1720-8386</eissn><abstract>Obestatin is a recently discovered 23 amino acids peptide derived from the ghrelin gene. As opposed to ghrelin, obestatin was shown to inhibit food intake in mice. The aims of this research were to study the effects of acute obestatin treatment on feeding behavior in the rat and its effects on GH and corticosterone secretion. Our results demonstrate that in young-adult male rats, obestatin effectively blunts the hunger caused by short-term starvation. Obestatin did not modify GH secretion in 10-day-old rats and did not antagonize the GH-releasing effects of hexarelin. Moreover, obestatin administration had no effects on spontaneous corticosterone secretion. In conclusion, these data demonstrate that in young-adult male rats the newly discovered obestatin can inhibit feeding but does not modify GH and corticosterone release in infant rats.</abstract><cop>Italy</cop><pmid>17033254</pmid><doi>10.1007/BF03344175</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0391-4097 |
| ispartof | Journal of endocrinological investigation, 2006-09, Vol.29 (8), p.RC16-RC18 |
| issn | 0391-4097 1720-8386 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68950357 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Animals, Newborn Corticosterone - blood Corticosterone - secretion Eating - drug effects Eating - physiology Feeding Behavior - drug effects Feeding Behavior - physiology Growth Hormone - blood Growth Hormone - secretion Male Oligopeptides - pharmacology Peptide Hormones - pharmacology Rats Rats, Sprague-Dawley |
| title | Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T01%3A07%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Obestatin%20inhibits%20feeding%20but%20does%20not%20modulate%20GH%20and%20corticosterone%20secretion%20in%20the%20rat&rft.jtitle=Journal%20of%20endocrinological%20investigation&rft.au=Bresciani,%20E&rft.date=2006-09-01&rft.volume=29&rft.issue=8&rft.spage=RC16&rft.epage=RC18&rft.pages=RC16-RC18&rft.issn=0391-4097&rft.eissn=1720-8386&rft_id=info:doi/10.1007/BF03344175&rft_dat=%3Cproquest_cross%3E68950357%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68950357&rft_id=info:pmid/17033254&rfr_iscdi=true |