A developmental study of the structural integrity of white matter in autism
Diffusion tensor imaging was used to examine developmental changes in the organization of white matter in a large sample of male participants with autism and controls between the ages of 10 and 35 years. Participants with autism had lower fractional anisotropy in areas within and near the corpus cal...
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| Veröffentlicht in: | Neuroreport 2007-01, Vol.18 (1), p.23-27 |
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| creator | Keller, Timothy A Kana, Rajesh K Just, Marcel Adam |
| description | Diffusion tensor imaging was used to examine developmental changes in the organization of white matter in a large sample of male participants with autism and controls between the ages of 10 and 35 years. Participants with autism had lower fractional anisotropy in areas within and near the corpus callosum and in the right retrolenticular portion of the internal capsule. Only one area, in the posterior limb of the right internal capsule, showed an interaction between age and group. The findings suggest that reductions in the structural integrity of white matter in autism persist into adulthood. These reductions may underlie the behavioral pattern observed in autism, as well as findings of reduced functional connectivity in functional magnetic resonance imaging signal between activating cortical areas. |
| doi_str_mv | 10.1097/01.wnr.0000239965.21685.99 |
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Participants with autism had lower fractional anisotropy in areas within and near the corpus callosum and in the right retrolenticular portion of the internal capsule. Only one area, in the posterior limb of the right internal capsule, showed an interaction between age and group. The findings suggest that reductions in the structural integrity of white matter in autism persist into adulthood. 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These reductions may underlie the behavioral pattern observed in autism, as well as findings of reduced functional connectivity in functional magnetic resonance imaging signal between activating cortical areas.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Anisotropy</subject><subject>Autistic Disorder - pathology</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Child</subject><subject>Child clinical studies</subject><subject>Developmental disorders</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Humans</subject><subject>Infantile autism</subject><subject>Internal Capsule - growth & development</subject><subject>Internal Capsule - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keller, Timothy A</creatorcontrib><creatorcontrib>Kana, Rajesh K</creatorcontrib><creatorcontrib>Just, Marcel Adam</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keller, Timothy A</au><au>Kana, Rajesh K</au><au>Just, Marcel Adam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A developmental study of the structural integrity of white matter in autism</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2007-01-08</date><risdate>2007</risdate><volume>18</volume><issue>1</issue><spage>23</spage><epage>27</epage><pages>23-27</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>Diffusion tensor imaging was used to examine developmental changes in the organization of white matter in a large sample of male participants with autism and controls between the ages of 10 and 35 years. Participants with autism had lower fractional anisotropy in areas within and near the corpus callosum and in the right retrolenticular portion of the internal capsule. Only one area, in the posterior limb of the right internal capsule, showed an interaction between age and group. The findings suggest that reductions in the structural integrity of white matter in autism persist into adulthood. These reductions may underlie the behavioral pattern observed in autism, as well as findings of reduced functional connectivity in functional magnetic resonance imaging signal between activating cortical areas.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>17259855</pmid><doi>10.1097/01.wnr.0000239965.21685.99</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Age Factors Anisotropy Autistic Disorder - pathology Biological and medical sciences Brain Mapping Child Child clinical studies Developmental disorders Diffusion Magnetic Resonance Imaging Humans Infantile autism Internal Capsule - growth & development Internal Capsule - pathology Male Medical sciences Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry |
| title | A developmental study of the structural integrity of white matter in autism |
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