Kinetics of Different Processes in Human Insulin Amyloid Formation

Human insulin has long been known to form amyloid fibrils under given conditions. The molecular basis of insulin aggregation is relevant for modeling the amyloidogenesis process, which is involved in many pathologies, as well as for improving delivery systems, used for diabetes treatments. Insulin a...

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Veröffentlicht in:	Journal of molecular biology 2007-02, Vol.366 (1), p.258-274
Hauptverfasser:	Manno, Mauro, Craparo, Emanuela Fabiola, Podestà, Alessandro, Bulone, Donatella, Carrotta, Rita, Martorana, Vincenzo, Tiana, Guido, San Biagio, Pier Luigi
Format:	Artikel
Sprache:	eng
Schlagworte:	aggregation Amyloid - biosynthesis Amyloid - chemistry Amyloid - ultrastructure amyloid fibrils atomic force microscopy Fluorescence Fluorescent Dyes - pharmacology Humans Hydrogen-Ion Concentration insulin Insulin - chemistry Kinetics light-scattering Microscopy, Atomic Force Microscopy, Phase-Contrast Models, Biological Particle Size Scattering, Radiation Temperature Thiazoles - pharmacology
Online-Zugang:	Volltext
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