Imaging of Germinal Center Selection Events During Affinity Maturation

The germinal center (GC) is an important site for the generation and selection of B cells bearing high-affinity antibodies, yet GC cell migration and interaction dynamics have not been directly observed. Using two-photon microscopy of mouse lymph nodes, we revealed that GC B cells are highly motile...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2007-01, Vol.315 (5811), p.528-531
Hauptverfasser:	Allen, Christopher D.C, Okada, Takaharu, Tang, H. Lucy, Cyster, Jason G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibody Affinity Antigens B lymphocytes B-Lymphocytes - cytology B-Lymphocytes - immunology B-Lymphocytes - physiology Biological and medical sciences Cell adhesion & migration Cell Cycle Cell Death Cell lines Cell Movement Cellular biology Dendritic Cells, Follicular - cytology Dendritic Cells, Follicular - physiology Fundamental and applied biological sciences. Psychology Fundamental immunology Germinal Center - cytology Germinal Center - immunology Globular star clusters Immune system Immunobiology Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Lymphoid tissue Macrophages - physiology Mice Mice, Inbred C57BL Microscopy - methods Models, Immunological Mutation Plasma cells rev genes Rodents Scientific imaging T lymphocytes T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - physiology
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