Copper-67 Radioimmunotherapy and Growth Inhibition by Anti–L1-Cell Adhesion Molecule Monoclonal Antibodies in a Therapy Model of Ovarian Cancer Metastasis

Purpose: We examined the tumor-targeting and therapeutic effects of 67 Cu-labeled single amino acid mutant forms of anti-L1 monoclonal antibody chCE7 in nude mice with orthotopically implanted SKOV3ip human ovarian carcinoma cells. Experimental Design: For radioimmunotherapy, chCE7 antibodies with a...

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Veröffentlicht in:	Clinical cancer research 2007-01, Vol.13 (2), p.603-611
Hauptverfasser:	Knogler, Karin, Grünberg, Jürgen, Zimmermann, Kurt, Cohrs, Susan, Honer, Michael, Ametamey, Simon, Altevogt, Peter, Fogel, Mina, Schubiger, P August, Novak-Hofer, Ilse
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-L1 antibody chCE7 Antibodies, Monoclonal - therapeutic use Cell Line, Tumor Copper Radioisotopes - therapeutic use Copper-67 Female Humans Mice Mice, Nude Mutation Neoplasm Metastasis Neural Cell Adhesion Molecule L1 - immunology Ovarian Neoplasms - immunology Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Plasmids - metabolism Positron-Emission Tomography - methods Radioimmunotherapy Radioimmunotherapy - methods
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