Analyzing proteome topology and function by automated multidimensional fluorescence microscopy

Temporal and spatial regulation of proteins contributes to function. We describe a multidimensional microscopic robot technology for high-throughput protein colocalization studies that runs cycles of fluorescence tagging, imaging and bleaching in situ . This technology combines three advances: a flu...

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Veröffentlicht in:	Nature biotechnology 2006-10, Vol.24 (10), p.1270-1278
Hauptverfasser:	Schubert, Walter, Bonnekoh, Bernd, Pommer, Ansgar J, Philipsen, Lars, Böckelmann, Raik, Malykh, Yanina, Gollnick, Harald, Friedenberger, Manuela, Bode, Marcus, Dress, Andreas W M
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Automation Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Bleaching Dermatitis, Atopic - metabolism Fluorescence Fluorescence microscopy Frequency distribution Fundamental and applied biological sciences. Psychology Humans Image Processing, Computer-Assisted Life Sciences Mass Spectrometry Microscopy Microscopy, Fluorescence - methods Pathology - methods Proteins Proteins - analysis Proteins - metabolism Proteomics Proteomics - methods Psoriasis - metabolism Reproducibility of Results Skin - metabolism Topology
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