metalloproteinase gene from the pathogenic piscine hemoflagellate, Cryptobia salmositica
We report the identification of a Cryptobia genomic DNA gene predicted to encode a hydrophobic protein containing a zinc metalloproteinase motif, HEXXH, and hence named it a major surface proteinase 1-like (MSP-1). The MSP-1 gene was identified using universal genome walking. Southern blot analysis...
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| Veröffentlicht in: | Parasitology research (1987) 2007-03, Vol.100 (4), p.899-904 |
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| container_title | Parasitology research (1987) |
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| creator | JESUDHASAN, Palmy R TAN, Chung-Wei WOO, Patrick T. K |
| description | We report the identification of a Cryptobia genomic DNA gene predicted to encode a hydrophobic protein containing a zinc metalloproteinase motif, HEXXH, and hence named it a major surface proteinase 1-like (MSP-1). The MSP-1 gene was identified using universal genome walking. Southern blot analysis revealed it to be a multicopy gene. Fragments of DNA encoding a segment homologous to the HEXXH motif of MSP-1 are widely found in bacteria, yeast, parasitic protozoans, plants, and animals including humans. These results suggest that the MSP-1 may have highly conserved functions, such as in intracellular proteolysis. |
| doi_str_mv | 10.1007/s00436-006-0340-7 |
| format | Article |
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These results suggest that the MSP-1 may have highly conserved functions, such as in intracellular proteolysis.</description><identifier>ISSN: 0932-0113</identifier><identifier>EISSN: 1432-1955</identifier><identifier>DOI: 10.1007/s00436-006-0340-7</identifier><identifier>PMID: 17171568</identifier><identifier>CODEN: PARREZ</identifier><language>eng</language><publisher>Berlin: Springer-Verlag</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; Biological and medical sciences ; Cryptobia ; Cryptobia salmositica ; Eukaryota - enzymology ; Eukaryota - genetics ; Fishes - parasitology ; Fundamental and applied biological sciences. Psychology ; General aspects ; General aspects and techniques. Study of several systematic groups. 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K</creatorcontrib><title>metalloproteinase gene from the pathogenic piscine hemoflagellate, Cryptobia salmositica</title><title>Parasitology research (1987)</title><addtitle>Parasitol Res</addtitle><description>We report the identification of a Cryptobia genomic DNA gene predicted to encode a hydrophobic protein containing a zinc metalloproteinase motif, HEXXH, and hence named it a major surface proteinase 1-like (MSP-1). The MSP-1 gene was identified using universal genome walking. Southern blot analysis revealed it to be a multicopy gene. Fragments of DNA encoding a segment homologous to the HEXXH motif of MSP-1 are widely found in bacteria, yeast, parasitic protozoans, plants, and animals including humans. These results suggest that the MSP-1 may have highly conserved functions, such as in intracellular proteolysis.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cryptobia</subject><subject>Cryptobia salmositica</subject><subject>Eukaryota - enzymology</subject><subject>Eukaryota - genetics</subject><subject>Fishes - parasitology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>General aspects and techniques. Study of several systematic groups. 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| ispartof | Parasitology research (1987), 2007-03, Vol.100 (4), p.899-904 |
| issn | 0932-0113 1432-1955 |
| language | eng |
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| subjects | Amino Acid Sequence Animals Base Sequence Biological and medical sciences Cryptobia Cryptobia salmositica Eukaryota - enzymology Eukaryota - genetics Fishes - parasitology Fundamental and applied biological sciences. Psychology General aspects General aspects and techniques. Study of several systematic groups. Models Invertebrates Metalloproteases - genetics Molecular Sequence Data Protozoan Proteins - chemistry Protozoan Proteins - genetics Protozoan Proteins - metabolism |
| title | metalloproteinase gene from the pathogenic piscine hemoflagellate, Cryptobia salmositica |
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