Optimization of a Stability-Indicating HPLC Method for the Simultaneous Determination of Rifampicin, Isoniazid, and Pyrazinamide in a Fixed-Dose Combination using Artificial Neural Networks

The aim of this study is to develop and optimize a simple and reliable high-performance liquid chromatography (HPLC) method for the simultaneous determination of rifampicin (RIF), isoniazid (INH), and pyrazinamide (PZA) in a fixed-dose combination. The method is developed and optimized using an arti...

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Veröffentlicht in:	Journal of chromatographic science 2007-01, Vol.45 (1), p.38-44
Hauptverfasser:	Glass, B.D., Agatonovic-Kustrin, S., Chen, Y.-J., Wisch, M.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological and medical sciences Biological Availability Chromatography, High Pressure Liquid - methods Drug Combinations General pharmacology Hydrogen-Ion Concentration Isoniazid - analysis Medical sciences Neural Networks (Computer) Pharmacology. Drug treatments Pyrazinamide - analysis Reproducibility of Results Rifampin - analysis Rifampin - pharmacokinetics Sensitivity and Specificity
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